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ONTOLOGY REPORT - ANNOTATIONS


Term:ubiquitin-dependent protein catabolic process via the N-end rule pathway
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Accession:GO:0071596 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation.
Synonyms:exact_synonym: ubiquitin-dependent protein breakdown via the N-end rule pathway;   ubiquitin-dependent protein catabolism via the N-end rule pathway;   ubiquitin-dependent protein degradation via the N-end rule pathway


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ubiquitin-dependent protein catabolic process via the N-end rule pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ubr1 ubiquitin protein ligase E3 component n-recognin 1 JBrowse link 3 112,800,557 112,910,038 RGD:13792537
G Ubr2 ubiquitin protein ligase E3 component n-recognin 2 JBrowse link 9 16,003,058 16,080,152 RGD:13792537
G Ubr3 ubiquitin protein ligase E3 component n-recognin 3 JBrowse link 3 56,125,927 56,283,908 RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19578
    metabolic process 11901
      primary metabolic process 10563
        protein metabolic process 6070
          protein catabolic process 970
            proteasomal protein catabolic process 478
              proteasome-mediated ubiquitin-dependent protein catabolic process 412
                ubiquitin-dependent protein catabolic process via the N-end rule pathway 3
Path 2
Term Annotations click to browse term
  biological_process 19578
    metabolic process 11901
      nitrogen compound metabolic process 10025
        organonitrogen compound metabolic process 6969
          organonitrogen compound catabolic process 1282
            protein catabolic process 970
              cellular protein catabolic process 804
                proteolysis involved in cellular protein catabolic process 751
                  modification-dependent protein catabolic process 639
                    ubiquitin-dependent protein catabolic process 628
                      proteasome-mediated ubiquitin-dependent protein catabolic process 412
                        ubiquitin-dependent protein catabolic process via the N-end rule pathway 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.