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ONTOLOGY REPORT - ANNOTATIONS


Term:transforming growth factor beta production
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Accession:GO:0071604 term browser browse the term
Definition:The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3.
Synonyms:exact_synonym: TGF-B production;   TGF-beta production;   TGFb production;   TGFbeta production
 narrow_synonym: transforming growth factor-beta secretion
 alt_id: GO:0038044


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transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgav integrin subunit alpha V ISO (MGI:MGI:5571208|PMID:24681597) RGD PMID:24681597 MGI:MGI:5571208 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgb6 integrin subunit beta 6 ISO (MGI:MGI:5571208|PMID:24681597) RGD PMID:24681597 MGI:MGI:5571208 NCBI chr 3:46,652,624...46,775,362
Ensembl chr 3:46,652,623...46,726,958
JBrowse link
negative regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2b activin A receptor type 2B ISO RGD DOI:10.1016/j.procbio.2011.10.027 NCBI chr 8:128,087,308...128,126,776
Ensembl chr 8:128,087,345...128,118,746
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISO
ISS
(PMID:20599762)
GO_REF:0000024
RGD
UniProt
PMID:20599762 GO_REF:0000024 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
negative regulation of transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbln1 fibulin 1 ISO (PMID:25834989) RGD PMID:25834989 NCBI chr 7:126,096,793...126,176,468
Ensembl chr 7:126,096,793...126,176,468
JBrowse link
G Fn1 fibronectin 1 ISO
IEA
(PMID:25834989)
GO_REF:0000107
RGD
Ensembl
PMID:25834989 GO_REF:0000107 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Il13 interleukin 13 IDA RGD PMID:20100461 RGD:4145466 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO MGI:MGI:3041135 (MGI:MGI:5529574|PMID:23994610) RGD PMID:23994610 MGI:MGI:5529574 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mir125a microRNA 125a IDA RGD PMID:29700287 RGD:26884455 NCBI chr 1:59,704,827...59,704,911
Ensembl chr 1:59,704,827...59,704,911
JBrowse link
negative regulation of transforming growth factor beta1 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd2ap CD2-associated protein ISO MGI:MGI:98725 (MGI:MGI:5297732|PMID:21911934) RGD PMID:21911934 MGI:MGI:5297732 NCBI chr 9:20,794,680...20,858,438
Ensembl chr 9:20,765,296...20,858,504
JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) ISO
IEA
(PMID:15899807)
GO_REF:0000107
RGD
Ensembl
PMID:15899807 GO_REF:0000107 NCBI chr 1:142,185,092...142,198,167
Ensembl chr 1:142,185,094...142,197,182
JBrowse link
G Gata6 GATA binding protein 6 IEA
ISO
GO_REF:0000107
(PMID:21127043)
Ensembl
RGD
PMID:21127043 GO_REF:0000107 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
G Laptm4b lysosomal protein transmembrane 4 beta ISO
ISS
(PMID:26126825)
GO_REF:0000024
RGD
UniProt
PMID:26126825 GO_REF:0000024 NCBI chr 7:72,924,911...72,968,099
Ensembl chr 7:72,924,799...72,968,101
JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp ISO
IBA
(MGI:MGI:5638298|PMID:25690660)
PMID:21873635
RGD PMID:25690660, PMID:21873635 MGI:MGI:5638298, RGD:13792537 NCBI chr 1:88,875,370...88,879,305
Ensembl chr 1:88,875,375...88,879,303
JBrowse link
negative regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh3 cadherin 3 ISO (PMID:22696062) RGD PMID:22696062 NCBI chr19:38,668,957...38,719,801
Ensembl chr19:38,669,230...38,719,677
JBrowse link
G Gata6 GATA binding protein 6 IEA
ISO
GO_REF:0000107
(PMID:21127043)
Ensembl
RGD
PMID:21127043 GO_REF:0000107 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
negative regulation of transforming growth factor beta3 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd24 CD24 molecule ISO
ISS
(PMID:16930538)
GO_REF:0000024
RGD
UniProt
PMID:16930538, PMID:16930538 GO_REF:0000024, RGD:8553566 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846
JBrowse link
positive regulation of transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd200 Cd200 molecule IEA
ISO
GO_REF:0000107
UniProtKB:P21272 (PMID:26670206)
Ensembl
RGD
PMID:26670206 GO_REF:0000107 NCBI chr11:60,371,617...60,398,450
Ensembl chr11:60,371,684...60,403,196
JBrowse link
G Cd34 CD34 molecule ISO
ISS
(PMID:17505307)
GO_REF:0000024
RGD
UniProt
PMID:17505307 GO_REF:0000024 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647
JBrowse link
G Cd46 CD46 molecule ISO (PMID:12540904) RGD PMID:12540904 NCBI chr13:113,786,525...113,818,741
Ensembl chr13:113,787,349...113,817,995
JBrowse link
G Fermt1 fermitin family member 1 ISO (MGI:MGI:5571208|PMID:24681597) RGD PMID:24681597 MGI:MGI:5571208 NCBI chr 3:125,566,744...125,607,864
Ensembl chr 3:125,566,643...125,607,735
JBrowse link
G Lgals9 galectin 9 ISO (PMID:20209097) RGD PMID:20209097 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
G Myb MYB proto-oncogene, transcription factor IMP RGD PMID:15534927 RGD:11532676 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP PMID:9630216 BHF-UCL PMID:9630216 RGD:5135054 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Serpinf2 serpin family F member 2 ISO (MGI:MGI:5306295|PMID:17958745)
(PMID:17958745), (PMID:20008146)
RGD PMID:17958745, PMID:20008146 MGI:MGI:5306295 NCBI chr10:62,264,247...62,272,353
Ensembl chr10:62,264,788...62,273,119
JBrowse link
G Thbs1 thrombospondin 1 IMP RGD PMID:17640965 RGD:2317942 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 ISO (PMID:18832695) RGD PMID:18832695 NCBI chr13:83,199,402...83,202,845
Ensembl chr13:83,199,264...83,202,864
JBrowse link
positive regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Furin furin (paired basic amino acid cleaving enzyme) ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:7737999)
UniProt
Ensembl
RGD
PMID:7737999 GO_REF:0000024, GO_REF:0000107 NCBI chr 1:142,185,092...142,198,167
Ensembl chr 1:142,185,094...142,197,182
JBrowse link
positive regulation of transforming growth factor beta1 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap2 ATPase H+ transporting accessory protein 2 ISO (PMID:16374430) RGD PMID:16374430 NCBI chr  X:11,137,889...11,164,854
Ensembl chr  X:11,136,939...11,164,915
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO
IEA
MGI:MGI:3608773 (MGI:MGI:3772530|PMID:18097059)
GO_REF:0000107
RGD
Ensembl
PMID:18097059 GO_REF:0000107, MGI:MGI:3772530 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Foxp3 forkhead box P3 ISO (MGI:MGI:3697020|PMID:17028180) RGD PMID:17028180 MGI:MGI:3697020 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Lum lumican ISO (MGI:MGI:5295830|PMID:21931815) RGD PMID:21931815 MGI:MGI:5295830 NCBI chr 7:38,820,058...38,826,862
Ensembl chr 7:38,819,771...38,826,862
JBrowse link
G Serpinb7 serpin family B member 7 IMP RGD PMID:21945418 RGD:7207383 NCBI chr13:27,282,456...27,354,775
Ensembl chr13:27,312,498...27,354,052
JBrowse link
positive regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 ISO MGI:MGI:1857283 (MGI:MGI:3759355|PMID:17767158) RGD PMID:17767158 MGI:MGI:3759355 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Wnt11 Wnt family member 11 ISO MGI:MGI:2665014 (MGI:MGI:3759355|PMID:17767158) RGD PMID:17767158 MGI:MGI:3759355 NCBI chr 1:163,794,136...163,813,756
Ensembl chr 1:163,797,660...163,813,756
JBrowse link
positive regulation of transforming growth factor beta3 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creb1 cAMP responsive element binding protein 1 IMP RGD PMID:16891311, PMID:21308733 RGD:1625706, RGD:10059386 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Smad3 SMAD family member 3 IMP RGD PMID:16891311 RGD:1625706 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgav integrin subunit alpha V ISO (PMID:22278742) RGD PMID:22278742 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgb6 integrin subunit beta 6 ISS
ISO
GO_REF:0000024
(PMID:22278742)
UniProt
RGD
PMID:22278742 GO_REF:0000024 NCBI chr 3:46,652,624...46,775,362
Ensembl chr 3:46,652,623...46,726,958
JBrowse link
G Itgb8 integrin subunit beta 8 ISO (MGI:MGI:5490445|PMID:22278742) RGD PMID:22278742 MGI:MGI:5490445 NCBI chr 6:147,089,280...147,172,846
Ensembl chr 6:147,094,097...147,172,813
JBrowse link
G Lrrc32 leucine rich repeat containing 32 ISO (PMID:19651619), (PMID:19750484), (PMID:22278742) RGD PMID:19651619, PMID:19750484, PMID:22278742 NCBI chr 1:163,443,972...163,457,426
Ensembl chr 1:163,445,527...163,457,424
JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 ISS
ISO
IEA
GO_REF:0000024
(PMID:2022183), (PMID:8617200)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:2022183, PMID:8617200 GO_REF:0000024, GO_REF:0000107 NCBI chr 6:21,203,502...21,600,441
Ensembl chr 6:21,203,502...21,600,451
JBrowse link
regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hif1a hypoxia inducible factor 1 subunit alpha ISO
IEA
(PMID:12411310)
GO_REF:0000107
RGD
Ensembl
PMID:12411310 GO_REF:0000107 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Smad3 SMAD family member 3 ISO (PMID:12411310) RGD PMID:12411310 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad4 SMAD family member 4 ISO
IEA
(PMID:12411310)
GO_REF:0000107
RGD
Ensembl
PMID:12411310 GO_REF:0000107 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 ISO
ISS
(PMID:12411310)
GO_REF:0000024
RGD
UniProt
PMID:12411310 GO_REF:0000024 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
regulation of transforming growth factor beta3 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrc32 leucine rich repeat containing 32 ISO (MGI:MGI:5920420|PMID:28912269) RGD PMID:28912269 MGI:MGI:5920420 NCBI chr 1:163,443,972...163,457,426
Ensembl chr 1:163,445,527...163,457,424
JBrowse link
transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ltbp3 latent transforming growth factor beta binding protein 3 ISO (PMID:18672106) RGD PMID:18672106 NCBI chr 1:221,099,155...221,116,096
Ensembl chr 1:221,099,998...221,116,096
JBrowse link
transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nrros negative regulator of reactive oxygen species ISS
ISO
GO_REF:0000024
(MGI:MGI:6192878|PMID:29909984)
UniProt
RGD
PMID:29909984 GO_REF:0000024, MGI:MGI:6192878 NCBI chr11:71,872,728...71,889,897
Ensembl chr11:71,872,830...71,889,887
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    multicellular organismal process 9055
      cytokine production 846
        transforming growth factor beta production 43
          negative regulation of transforming growth factor beta production + 14
          positive regulation of transforming growth factor beta production + 20
          regulation of transforming growth factor beta production + 41
          transforming growth factor beta activation + 10
          transforming growth factor beta1 production + 11
          transforming growth factor beta2 production + 8
          transforming growth factor beta3 production + 4
Path 2
Term Annotations click to browse term
  biological_process 20017
    metabolic process 12256
      organic substance metabolic process 11636
        macromolecule metabolic process 10081
          gene expression 6295
            cytokine production 846
              transforming growth factor beta production 43
                negative regulation of transforming growth factor beta production + 14
                positive regulation of transforming growth factor beta production + 20
                regulation of transforming growth factor beta production + 41
                transforming growth factor beta activation + 10
                transforming growth factor beta1 production + 11
                transforming growth factor beta2 production + 8
                transforming growth factor beta3 production + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.