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ONTOLOGY REPORT - ANNOTATIONS


Term:transforming growth factor beta production
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Accession:GO:0071604 term browser browse the term
Definition:The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3.
Synonyms:exact_synonym: TGF-B production;   TGF-beta production;   TGFb production;   TGFbeta production
 narrow_synonym: transforming growth factor-beta secretion
 alt_id: GO:0038044


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transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ITGAV integrin subunit alpha V ISO (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chr2B:73,880,962...73,972,486
Ensembl chr2B:191,680,655...191,773,028
JBrowse link
G ITGB6 integrin subunit beta 6 ISO (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chr2B:47,386,913...47,496,491
Ensembl chr2B:164,764,251...164,867,426
JBrowse link
negative regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR2B activin A receptor type 2B ISO AgBase DOI:10.1016/j.procbio.2011.10.027 NCBI chr 3:38,350,838...38,389,839
Ensembl chr 3:38,633,093...38,662,063
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 ISO (PMID:20599762) UniProtKB PMID:20599762 NCBI chr 6:43,842,796...43,849,637
Ensembl chr 6:45,125,773...45,133,872
JBrowse link
negative regulation of transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FBLN1 fibulin 1 ISO (PMID:25834989) UniProt PMID:25834989 NCBI chr22:26,390,379...26,488,737 JBrowse link
G FN1 fibronectin 1 ISO (PMID:25834989) UniProt PMID:25834989 NCBI chr2B:102,623,568...102,698,747
Ensembl chr2B:221,208,431...221,284,003
JBrowse link
G IL13 interleukin 13 ISO RGD PMID:20100461 RGD:4145466 NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO (MGI:MGI:5529574|PMID:23994610) MGI PMID:23994610 MGI:MGI:5529574 NCBI chr 7:108,646,278...108,772,238
Ensembl chr 7:121,365,438...121,468,159
JBrowse link
negative regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FKBP1A FKBP prolyl isomerase 1A ISO (PMID:11583628) FlyBase PMID:11583628 NCBI chr20:1,519,330...1,548,473 JBrowse link
negative regulation of transforming growth factor beta1 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD2AP CD2 associated protein ISO (MGI:MGI:5297732|PMID:21911934) MGI PMID:21911934 MGI:MGI:5297732 NCBI chr 6:47,065,284...47,210,746
Ensembl chr 6:48,328,863...48,474,163
JBrowse link
G FURIN furin, paired basic amino acid cleaving enzyme ISO (PMID:15899807) BHF-UCL PMID:15899807 NCBI chr15:69,560,774...69,576,007
Ensembl chr15:88,763,269...88,774,023
JBrowse link
G GATA6 GATA binding protein 6 ISO (PMID:21127043) UniProtKB PMID:21127043 NCBI chr18:15,411,764...15,444,402 JBrowse link
G LAPTM4B lysosomal protein transmembrane 4 beta ISO (PMID:26126825) UniProtKB PMID:26126825 NCBI chr 8:94,414,275...94,491,483 JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP ISO (MGI:MGI:5638298|PMID:25690660) ARUK-UCL PMID:25690660 MGI:MGI:5638298 NCBI chr19:32,821,279...32,825,488
Ensembl chr19:41,570,683...41,575,226
JBrowse link
negative regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDH3 cadherin 3 ISO (PMID:22696062) UniProtKB PMID:22696062 NCBI chr16:49,015,115...49,071,903
Ensembl chr16:68,407,625...68,465,287
JBrowse link
G GATA6 GATA binding protein 6 ISO (PMID:21127043) UniProtKB PMID:21127043 NCBI chr18:15,411,764...15,444,402 JBrowse link
negative regulation of transforming growth factor beta3 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD24 CD24 molecule ISO (PMID:16930538) UniProtKB PMID:16930538 NCBI chr 6:104,783,720...104,789,509
Ensembl chr 6:108,655,624...108,657,847
JBrowse link
positive regulation of transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD200 CD200 molecule ISO (PMID:26670206) ARUK-UCL PMID:26670206 NCBI chr 3:109,481,067...109,511,261
Ensembl chr 3:116,404,728...116,434,363
JBrowse link
G CD34 CD34 molecule ISO (PMID:17505307) UniProtKB PMID:17505307 NCBI chr 1:183,459,028...183,489,583
Ensembl chr 1:188,272,551...188,297,384
JBrowse link
G CD46 CD46 molecule ISO (PMID:12540904) UniProtKB PMID:12540904 NCBI chr 1:183,330,423...183,373,916
Ensembl chr 1:188,031,758...188,182,046
JBrowse link
G FERMT1 fermitin family member 1 ISO (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chr20:6,063,480...6,120,206
Ensembl chr20:5,856,287...5,902,251
JBrowse link
G LGALS9 galectin 9 ISO (PMID:20209097) UniProtKB PMID:20209097 NCBI chr17:29,125,460...29,145,028
Ensembl chr17:29,623,398...29,642,959
JBrowse link
G MYB MYB proto-oncogene, transcription factor ISO RGD PMID:15534927 RGD:11532676 NCBI chr 6:132,952,728...132,990,560
Ensembl chr 6:137,048,812...137,086,194
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO PMID:9630216 BHF-UCL PMID:9630216 RGD:5135054 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519
JBrowse link
G SERPINF2 serpin family F member 2 ISO (MGI:MGI:5306295|PMID:17958745)
(PMID:17958745), (PMID:20008146)
BHF-UCL PMID:17958745, PMID:20008146 MGI:MGI:5306295 NCBI chr17:1,725,469...1,738,887
Ensembl chr17:1,618,549...1,631,570
JBrowse link
G THBS1 thrombospondin 1 ISO RGD PMID:17640965 RGD:2317942 NCBI chr15:18,521,802...18,538,172
Ensembl chr15:36,776,756...36,793,170
JBrowse link
G XCL1 X-C motif chemokine ligand 1 ISO (PMID:18832695) BHF-UCL PMID:18832695 NCBI chr 1:143,837,578...144,068,261
Ensembl chr 1:147,785,654...147,790,587
JBrowse link
positive regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FURIN furin, paired basic amino acid cleaving enzyme ISO (PMID:7737999) UniProt PMID:7737999 NCBI chr15:69,560,774...69,576,007
Ensembl chr15:88,763,269...88,774,023
JBrowse link
positive regulation of transforming growth factor beta1 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP6AP2 ATPase H+ transporting accessory protein 2 ISO (PMID:16374430) HGNC PMID:16374430 NCBI chr  X:33,026,525...33,052,252
Ensembl chr  X:40,730,677...40,756,209
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 ISO (MGI:MGI:3772530|PMID:18097059) MGI PMID:18097059 MGI:MGI:3772530 NCBI chr16:37,646,447...37,659,078
Ensembl chr16:56,779,065...56,791,760
JBrowse link
G FOXP3 forkhead box P3 ISO (MGI:MGI:3697020|PMID:17028180) MGI PMID:17028180 MGI:MGI:3697020 NCBI chr  X:41,550,462...41,567,492
Ensembl chr  X:49,402,652...49,417,029
JBrowse link
G LUM lumican ISO (MGI:MGI:5295830|PMID:21931815) CACAO PMID:21931815 MGI:MGI:5295830 NCBI chr12:88,636,825...88,644,665
Ensembl chr12:91,952,277...91,960,388
JBrowse link
G SERPINB7 serpin family B member 7 ISO RGD PMID:21945418 RGD:7207383 NCBI chr18:57,112,242...57,164,213
Ensembl chr18:60,445,135...60,475,165
JBrowse link
positive regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF2 activating transcription factor 2 ISO (MGI:MGI:3759355|PMID:17767158) MGI PMID:17767158 MGI:MGI:3759355 NCBI chr2B:62,348,245...62,444,428
Ensembl chr2B:179,799,365...179,895,007
JBrowse link
G WNT11 Wnt family member 11 ISO (MGI:MGI:3759355|PMID:17767158) MGI PMID:17767158 MGI:MGI:3759355 NCBI chr11:71,239,781...71,263,915
Ensembl chr11:74,540,169...74,560,024
JBrowse link
positive regulation of transforming growth factor beta3 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CREB1 cAMP responsive element binding protein 1 ISO RGD PMID:16891311, PMID:21308733 RGD:10059386, RGD:1625706 NCBI chr2B:94,762,796...94,836,304
Ensembl chr2B:212,891,261...212,958,130
JBrowse link
G SMAD3 SMAD family member 3 ISO RGD PMID:16891311 RGD:1625706 NCBI chr15:46,013,764...46,143,126
Ensembl chr15:64,284,949...64,414,185
JBrowse link
regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ITGAV integrin subunit alpha V ISO (PMID:22278742) UniProt PMID:22278742 NCBI chr2B:73,880,962...73,972,486
Ensembl chr2B:191,680,655...191,773,028
JBrowse link
G ITGB6 integrin subunit beta 6 ISO (PMID:22278742) UniProt PMID:22278742 NCBI chr2B:47,386,913...47,496,491
Ensembl chr2B:164,764,251...164,867,426
JBrowse link
G ITGB8 integrin subunit beta 8 ISO (MGI:MGI:5490445|PMID:22278742) UniProt PMID:22278742 MGI:MGI:5490445 NCBI chr 7:21,019,917...21,105,143
Ensembl chr 7:20,336,031...20,415,666
JBrowse link
G LRRC32 leucine rich repeat containing 32 ISO (PMID:19651619), (PMID:19750484), (PMID:22278742) UniProt PMID:19651619, PMID:19750484, PMID:22278742 NCBI chr11:71,708,222...71,721,426
Ensembl chr11:75,354,997...75,367,440
JBrowse link
G LTBP1 latent transforming growth factor beta binding protein 1 ISO (PMID:2022183), (PMID:8617200) UniProt PMID:2022183, PMID:8617200 NCBI chr2A:32,956,937...33,409,286
Ensembl chr2A:33,667,191...34,120,602
JBrowse link
regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HIF1A hypoxia inducible factor 1 subunit alpha ISO (PMID:12411310) BHF-UCL PMID:12411310 NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885
JBrowse link
G SMAD3 SMAD family member 3 ISO (PMID:12411310) BHF-UCL PMID:12411310 NCBI chr15:46,013,764...46,143,126
Ensembl chr15:64,284,949...64,414,185
JBrowse link
G SMAD4 SMAD family member 4 ISO (PMID:12411310) BHF-UCL PMID:12411310 NCBI chr18:44,402,112...44,456,779
Ensembl chr18:47,764,568...47,797,359
JBrowse link
G TGFB2 transforming growth factor beta 2 ISO (PMID:12411310) BHF-UCL PMID:12411310 NCBI chr 1:193,907,398...194,005,800
Ensembl chr 1:198,758,751...198,859,041
JBrowse link
regulation of transforming growth factor beta3 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LRRC32 leucine rich repeat containing 32 ISO (MGI:MGI:5920420|PMID:28912269) UniProt PMID:28912269 MGI:MGI:5920420 NCBI chr11:71,708,222...71,721,426
Ensembl chr11:75,354,997...75,367,440
JBrowse link
transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LTBP3 latent transforming growth factor beta binding protein 3 ISO (PMID:18672106) UniProtKB PMID:18672106 NCBI chr11:60,897,897...60,917,690
Ensembl chr11:64,233,504...64,252,802
JBrowse link
transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NRROS negative regulator of reactive oxygen species ISO (MGI:MGI:6192878|PMID:29909984) UniProt PMID:29909984 MGI:MGI:6192878 NCBI chr 3:193,984,797...194,007,173
Ensembl chr 3:203,920,334...203,948,506
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12564
    multicellular organismal process 6494
      cytokine production 774
        transforming growth factor beta production 43
          negative regulation of transforming growth factor beta production + 14
          positive regulation of transforming growth factor beta production + 20
          regulation of transforming growth factor beta production + 41
          transforming growth factor beta activation + 11
          transforming growth factor beta1 production + 12
          transforming growth factor beta2 production + 8
          transforming growth factor beta3 production + 4
Path 2
Term Annotations click to browse term
  biological_process 12564
    metabolic process 7979
      organic substance metabolic process 7672
        macromolecule metabolic process 6628
          gene expression 4095
            cytokine production 774
              transforming growth factor beta production 43
                negative regulation of transforming growth factor beta production + 14
                positive regulation of transforming growth factor beta production + 20
                regulation of transforming growth factor beta production + 41
                transforming growth factor beta activation + 11
                transforming growth factor beta1 production + 12
                transforming growth factor beta2 production + 8
                transforming growth factor beta3 production + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.