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ONTOLOGY REPORT - ANNOTATIONS


Term:transforming growth factor beta production
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Accession:GO:0071604 term browser browse the term
Definition:The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3.
Synonyms:exact_synonym: TGF-B production;   TGF-beta production;   TGFb production;   TGFbeta production
 narrow_synonym: transforming growth factor-beta secretion
 alt_id: GO:0038044


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transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgav integrin subunit alpha V ISO (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chrNW_004955403:11,588,536...11,669,809
Ensembl chrNW_004955403:11,592,339...11,659,297
JBrowse link
G Itgb6 integrin subunit beta 6 ISO (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chrNW_004955449:13,387,013...13,520,879
Ensembl chrNW_004955449:13,448,084...13,520,879
JBrowse link
negative regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2b activin A receptor type 2B ISO AgBase DOI:10.1016/j.procbio.2011.10.027 NCBI chrNW_004955427:25,438,652...25,467,360
Ensembl chrNW_004955427:25,438,652...25,467,360
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISO (PMID:20599762) UniProtKB PMID:20599762 NCBI chrNW_004955437:9,872,649...9,878,459
Ensembl chrNW_004955437:9,873,908...9,878,459
JBrowse link
negative regulation of transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbln1 fibulin 1 ISO (PMID:25834989) UniProt PMID:25834989 NCBI chrNW_004955413:29,837,134...29,911,313
Ensembl chrNW_004955413:29,837,134...29,912,222
JBrowse link
G Fn1 fibronectin 1 ISO (PMID:25834989) UniProt PMID:25834989 NCBI chrNW_004955457:629,599...694,948
Ensembl chrNW_004955457:629,518...696,975
JBrowse link
G Il13 interleukin 13 ISO RGD PMID:20100461 RGD:4145466 NCBI chrNW_004955408:4,046,406...4,049,795 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO (MGI:MGI:5529574|PMID:23994610) MGI PMID:23994610 MGI:MGI:5529574 NCBI chrNW_004955432:22,440,671...22,519,592
Ensembl chrNW_004955432:22,440,637...22,517,647
JBrowse link
negative regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fkbp1a FKBP prolyl isomerase 1A ISO (PMID:11583628) FlyBase PMID:11583628 NCBI chrNW_004955596:580,106...606,210 JBrowse link
negative regulation of transforming growth factor beta1 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd2ap CD2 associated protein ISO (MGI:MGI:5297732|PMID:21911934) MGI PMID:21911934 MGI:MGI:5297732 NCBI chrNW_004955437:12,005,399...12,087,014
Ensembl chrNW_004955437:11,983,311...12,091,100
JBrowse link
G Furin furin, paired basic amino acid cleaving enzyme ISO (PMID:15899807) BHF-UCL PMID:15899807 NCBI chrNW_004955416:14,915,031...14,947,634
Ensembl chrNW_004955416:14,936,546...14,949,252
JBrowse link
G Laptm4b lysosomal protein transmembrane 4 beta ISO (PMID:26126825) UniProtKB PMID:26126825 NCBI chrNW_004955417:13,574,493...13,625,669
Ensembl chrNW_004955417:13,574,721...13,625,313
JBrowse link
G Tyrobp transmembrane immune signaling adaptor TYROBP ISO (MGI:MGI:5638298|PMID:25690660) ARUK-UCL PMID:25690660 MGI:MGI:5638298 NCBI chrNW_004955468:2,673,657...2,677,633
Ensembl chrNW_004955468:2,673,980...2,677,321
JBrowse link
negative regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh3 cadherin 3 ISO (PMID:22696062) UniProtKB PMID:22696062 NCBI chrNW_004955484:7,937,847...7,985,418
Ensembl chrNW_004955484:7,938,495...7,986,231
JBrowse link
negative regulation of transforming growth factor beta3 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd24 CD24 molecule ISO (PMID:16930538) UniProtKB PMID:16930538 NCBI chrNW_004955411:32,270,881...32,275,236 JBrowse link
positive regulation of transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd34 CD34 molecule ISO (PMID:17505307) UniProtKB PMID:17505307 NCBI chrNW_004955406:43,116,688...43,130,405
Ensembl chrNW_004955406:43,117,816...43,130,463
JBrowse link
G Cd46 CD46 molecule ISO (PMID:12540904) UniProtKB PMID:12540904 NCBI chrNW_004955406:43,002,817...43,034,555 JBrowse link
G Fermt1 fermitin family member 1 ISO (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chrNW_004955415:16,447,921...16,483,221
Ensembl chrNW_004955415:16,446,934...16,483,369
JBrowse link
G Lgals9 galectin 9 ISO (PMID:20209097) UniProtKB PMID:20209097 NCBI chrNW_004955481:5,234,125...5,249,564 JBrowse link
G Myb MYB proto-oncogene, transcription factor ISO RGD PMID:15534927 RGD:11532676 NCBI chrNW_004955439:1,523,516...1,560,185
Ensembl chrNW_004955439:1,521,292...1,560,220
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO PMID:9630216 BHF-UCL PMID:9630216 RGD:5135054 NCBI chrNW_004955406:25,077,988...25,086,259
Ensembl chrNW_004955406:25,079,945...25,086,171
JBrowse link
G Serpinf2 serpin family F member 2 ISO (PMID:17958745), (PMID:20008146)
(MGI:MGI:5306295|PMID:17958745)
BHF-UCL PMID:17958745, PMID:20008146 MGI:MGI:5306295 NCBI chrNW_004955481:1,441,262...1,449,078
Ensembl chrNW_004955481:1,442,010...1,449,242
JBrowse link
G Thbs1 thrombospondin 1 ISO RGD PMID:17640965 RGD:2317942 NCBI chrNW_004955416:6,490,034...6,506,419
Ensembl chrNW_004955416:6,489,451...6,506,419
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 ISO (PMID:18832695) BHF-UCL PMID:18832695 NCBI chrNW_004955462:8,594,416...8,598,101 JBrowse link
positive regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Furin furin, paired basic amino acid cleaving enzyme ISO (PMID:7737999) UniProt PMID:7737999 NCBI chrNW_004955416:14,915,031...14,947,634
Ensembl chrNW_004955416:14,936,546...14,949,252
JBrowse link
positive regulation of transforming growth factor beta1 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap2 ATPase H+ transporting accessory protein 2 ISO (PMID:16374430) HGNC PMID:16374430 NCBI chrNW_004955565:2,006,154...2,029,921 JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO (MGI:MGI:3772530|PMID:18097059) MGI PMID:18097059 MGI:MGI:3772530 NCBI chrNW_004955433:15,023,272...15,034,650
Ensembl chrNW_004955433:15,023,050...15,034,711
JBrowse link
G Foxp3 forkhead box P3 ISO (MGI:MGI:3697020|PMID:17028180) MGI PMID:17028180 MGI:MGI:3697020 NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606
JBrowse link
G Lum lumican ISO (MGI:MGI:5295830|PMID:21931815) CACAO PMID:21931815 MGI:MGI:5295830 NCBI chrNW_004955405:28,299,966...28,307,982
Ensembl chrNW_004955405:28,298,988...28,308,054
JBrowse link
G Serpinb7 serpin family B member 7 ISO RGD PMID:21945418 RGD:7207383 NCBI chrNW_004955402:47,599,503...47,649,537
Ensembl chrNW_004955402:47,599,150...47,649,885
JBrowse link
positive regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 ISO (MGI:MGI:3759355|PMID:17767158) MGI PMID:17767158 MGI:MGI:3759355 NCBI chrNW_004955449:332,563...411,218
Ensembl chrNW_004955449:338,193...411,218
JBrowse link
G Wnt11 Wnt family member 11 ISO (MGI:MGI:3759355|PMID:17767158) MGI PMID:17767158 MGI:MGI:3759355 NCBI chrNW_004955414:15,674,478...15,694,758
Ensembl chrNW_004955414:15,674,940...15,694,883
JBrowse link
positive regulation of transforming growth factor beta3 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creb1 cAMP responsive element binding protein 1 ISO RGD PMID:16891311, PMID:21308733 RGD:10059386, RGD:1625706 NCBI chrNW_004955457:7,424,403...7,490,630
Ensembl chrNW_004955457:7,431,736...7,491,149
JBrowse link
G Smad3 SMAD family member 3 ISO RGD PMID:16891311 RGD:1625706 NCBI chrNW_004955450:8,747,651...8,842,003
Ensembl chrNW_004955450:8,747,651...8,842,136
JBrowse link
regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgav integrin subunit alpha V ISO (PMID:22278742) UniProt PMID:22278742 NCBI chrNW_004955403:11,588,536...11,669,809
Ensembl chrNW_004955403:11,592,339...11,659,297
JBrowse link
G Itgb6 integrin subunit beta 6 ISO (PMID:22278742) UniProt PMID:22278742 NCBI chrNW_004955449:13,387,013...13,520,879
Ensembl chrNW_004955449:13,448,084...13,520,879
JBrowse link
G Itgb8 integrin subunit beta 8 ISO (MGI:MGI:5490445|PMID:22278742) UniProt PMID:22278742 MGI:MGI:5490445 NCBI chrNW_004955410:23,011,874...23,099,191
Ensembl chrNW_004955410:23,011,973...23,097,021
JBrowse link
G Lrrc32 leucine rich repeat containing 32 ISO (PMID:19651619), (PMID:19750484), (PMID:22278742) UniProt PMID:19651619, PMID:19750484, PMID:22278742 NCBI chrNW_004955414:15,296,704...15,309,088
Ensembl chrNW_004955414:15,296,563...15,309,088
JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 ISO (PMID:2022183), (PMID:8617200) UniProt PMID:2022183, PMID:8617200 NCBI chrNW_004955441:1,405,340...1,626,668
Ensembl chrNW_004955441:1,232,041...1,627,470
JBrowse link
regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hif1a hypoxia inducible factor 1 subunit alpha ISO (PMID:12411310) BHF-UCL PMID:12411310 NCBI chrNW_004955466:8,000,311...8,022,497
Ensembl chrNW_004955466:8,000,044...8,022,497
JBrowse link
G Smad3 SMAD family member 3 ISO (PMID:12411310) BHF-UCL PMID:12411310 NCBI chrNW_004955450:8,747,651...8,842,003
Ensembl chrNW_004955450:8,747,651...8,842,136
JBrowse link
G Smad4 SMAD family member 4 ISO (PMID:12411310) BHF-UCL PMID:12411310 NCBI chrNW_004955402:35,956,080...36,001,746
Ensembl chrNW_004955402:35,961,165...35,994,538
JBrowse link
G Tgfb2 transforming growth factor beta 2 ISO (PMID:12411310) BHF-UCL PMID:12411310 NCBI chrNW_004955406:174,949...249,248
Ensembl chrNW_004955406:172,814...249,248
JBrowse link
regulation of transforming growth factor beta3 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrc32 leucine rich repeat containing 32 ISO (MGI:MGI:5920420|PMID:28912269) UniProt PMID:28912269 MGI:MGI:5920420 NCBI chrNW_004955414:15,296,704...15,309,088
Ensembl chrNW_004955414:15,296,563...15,309,088
JBrowse link
transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ltbp3 latent transforming growth factor beta binding protein 3 ISO (PMID:18672106) UniProtKB PMID:18672106 NCBI chrNW_004955422:19,714,161...19,730,344
Ensembl chrNW_004955422:19,714,627...19,729,855
JBrowse link
transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nrros negative regulator of reactive oxygen species ISO (MGI:MGI:6192878|PMID:29909984) UniProt PMID:29909984 MGI:MGI:6192878 NCBI chrNW_004955420:12,792,173...12,798,645
Ensembl chrNW_004955420:12,792,111...12,801,963
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11889
    multicellular organismal process 6168
      cytokine production 641
        transforming growth factor beta production 41
          negative regulation of transforming growth factor beta production + 13
          positive regulation of transforming growth factor beta production + 19
          regulation of transforming growth factor beta production + 39
          transforming growth factor beta activation + 11
          transforming growth factor beta1 production + 11
          transforming growth factor beta2 production + 7
          transforming growth factor beta3 production + 4
Path 2
Term Annotations click to browse term
  biological_process 11889
    metabolic process 7609
      organic substance metabolic process 7318
        macromolecule metabolic process 6345
          gene expression 3933
            cytokine production 641
              transforming growth factor beta production 41
                negative regulation of transforming growth factor beta production + 13
                positive regulation of transforming growth factor beta production + 19
                regulation of transforming growth factor beta production + 39
                transforming growth factor beta activation + 11
                transforming growth factor beta1 production + 11
                transforming growth factor beta2 production + 7
                transforming growth factor beta3 production + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.