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ONTOLOGY REPORT - ANNOTATIONS


Term:transforming growth factor beta production
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Accession:GO:0071604 term browser browse the term
Definition:The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3.
Synonyms:exact_synonym: TGF-B production;   TGF-beta production;   TGFb production;   TGFbeta production
 narrow_synonym: transforming growth factor-beta secretion
 alt_id: GO:0038044


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transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ITGAV integrin subunit alpha V ISO (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chr36:28,815,215...28,890,569
Ensembl chr36:28,804,013...28,887,430
JBrowse link
G ITGB6 integrin subunit beta 6 ISO (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chr36:5,833,206...5,962,699
Ensembl chr36:5,834,638...5,962,633
JBrowse link
negative regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR2B activin A receptor type 2B ISO AgBase DOI:10.1016/j.procbio.2011.10.027 NCBI chr23:8,211,555...8,225,596
Ensembl chr23:8,192,483...8,218,894
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 IEA Ensembl GO_REF:0000107 NCBI chr12:12,658,415...12,664,945
Ensembl chr12:12,660,008...12,664,940
JBrowse link
negative regulation of transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FBLN1 fibulin 1 ISO (PMID:25834989) UniProt PMID:25834989 NCBI chr10:20,498,097...20,564,776
Ensembl chr10:20,498,567...20,627,836
JBrowse link
G FN1 fibronectin 1 ISO (PMID:25834989) UniProt PMID:25834989 NCBI chr37:22,456,854...22,522,410
Ensembl chr37:22,420,428...22,523,123
JBrowse link
G IL13 interleukin 13 ISO RGD PMID:20100461 RGD:4145466 NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO (MGI:MGI:5529574|PMID:23994610) MGI PMID:23994610 MGI:MGI:5529574 NCBI chr14:55,599,047...55,711,626
Ensembl chr14:55,598,337...55,724,027
JBrowse link
G MIR125A microRNA mir-125a ISO RGD PMID:29700287 RGD:26884455 NCBI chr 1:105,400,273...105,400,332
Ensembl chr 1:105,400,270...105,400,337
JBrowse link
negative regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FKBP1A FKBP prolyl isomerase 1A ISO (PMID:11583628) FlyBase PMID:11583628 NCBI chr24:19,618,581...19,643,685
Ensembl chr24:19,618,558...19,643,046
JBrowse link
negative regulation of transforming growth factor beta1 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD2AP CD2 associated protein IEA Ensembl GO_REF:0000107 NCBI chr12:15,538,215...15,683,619
Ensembl chr12:15,538,356...15,681,011
JBrowse link
G FURIN furin, paired basic amino acid cleaving enzyme IEA Ensembl GO_REF:0000107 NCBI chr 3:53,357,491...53,368,285
Ensembl chr 3:53,358,045...53,365,423
JBrowse link
G GATA6 GATA binding protein 6 ISO (PMID:21127043) UniProtKB PMID:21127043 NCBI chr 7:65,932,114...65,962,574 JBrowse link
G LAPTM4B lysosomal protein transmembrane 4 beta IEA Ensembl GO_REF:0000107 NCBI chr13:41,134...127,399
Ensembl chr13:41,121...127,182
JBrowse link
G NFKBID NFKB inhibitor delta IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:116,763,371...116,770,683
Ensembl chr 1:116,757,289...116,772,325
JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr 1:116,757,271...116,760,453
Ensembl chr 1:116,757,289...116,772,325
JBrowse link
negative regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDH3 cadherin 3 IEA Ensembl GO_REF:0000107 NCBI chr 5:80,864,859...80,912,136
Ensembl chr 5:80,863,661...80,913,019
JBrowse link
G GATA6 GATA binding protein 6 ISO (PMID:21127043) UniProtKB PMID:21127043 NCBI chr 7:65,932,114...65,962,574 JBrowse link
positive regulation of transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD200 CD200 molecule IEA Ensembl GO_REF:0000107 NCBI chr33:16,872,849...16,892,161
Ensembl chr33:16,873,048...16,890,954
JBrowse link
G CD34 CD34 molecule ISS
IEA
UniProtKB
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr 7:6,734,363...6,747,991
Ensembl chr 7:6,734,363...6,748,581
JBrowse link
G FERMT1 fermitin family member 1 ISO (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chr24:15,748,632...15,785,025
Ensembl chr24:15,748,629...15,782,880
JBrowse link
G LGALS9 galectin 9 ISO (PMID:20209097) UniProtKB PMID:20209097 NCBI chr 9:42,154,613...42,170,423
Ensembl chr 9:42,154,702...42,170,391
JBrowse link
G LOC490356 cytokine SCM-1 beta ISO (PMID:18832695) BHF-UCL PMID:18832695 NCBI chr 7:29,986,433...29,991,096 JBrowse link
G LOC609365 CD46 molecule, complement regulatory protein-like ISO (PMID:12540904) UniProtKB PMID:12540904 NCBI chr 7:6,602,762...6,646,561 JBrowse link
G MYB MYB proto-oncogene, transcription factor ISO RGD PMID:15534927 RGD:11532676 NCBI chr 1:27,908,309...27,991,984
Ensembl chr 1:27,908,364...27,991,969
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO PMID:9630216 BHF-UCL PMID:9630216 RGD:5135054 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
G SERPINF2 serpin family F member 2 IEA Ensembl GO_REF:0000107 NCBI chr 9:45,876,076...45,883,777
Ensembl chr 9:45,877,495...45,883,036
JBrowse link
G THBS1 thrombospondin 1 ISO RGD PMID:17640965 RGD:2317942 NCBI chr30:6,770,212...6,786,875
Ensembl chr30:6,769,470...6,784,915
JBrowse link
positive regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FURIN furin, paired basic amino acid cleaving enzyme IEA Ensembl GO_REF:0000107 NCBI chr 3:53,357,491...53,368,285
Ensembl chr 3:53,358,045...53,365,423
JBrowse link
positive regulation of transforming growth factor beta1 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP6AP2 ATPase H+ transporting accessory protein 2 IEA Ensembl GO_REF:0000107 NCBI chr  X:35,050,588...35,073,633
Ensembl chr  X:35,050,606...35,073,067
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:59,022,794...59,032,095
Ensembl chr 2:59,022,794...59,032,095
JBrowse link
G FOXP3 forkhead box P3 IEA Ensembl GO_REF:0000107 NCBI chr  X:42,331,229...42,362,841
Ensembl chr  X:42,344,108...42,350,758
JBrowse link
G LUM lumican IEA Ensembl GO_REF:0000107 NCBI chr15:31,792,872...31,800,444
Ensembl chr15:31,793,233...31,800,912
JBrowse link
G SERPINB7 serpin family B member 7 ISO RGD PMID:21945418 RGD:7207383 NCBI chr 1:13,336,067...13,392,674
Ensembl chr 1:13,336,837...13,358,125
JBrowse link
positive regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF2 activating transcription factor 2 IEA Ensembl GO_REF:0000107 NCBI chr36:19,032,376...19,103,382
Ensembl chr36:19,010,717...19,103,292
JBrowse link
G WNT11 Wnt family member 11 IEA Ensembl GO_REF:0000107 NCBI chr21:22,442,496...22,463,040
Ensembl chr21:22,446,051...22,463,173
JBrowse link
positive regulation of transforming growth factor beta3 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CREB1 cAMP responsive element binding protein 1 ISO RGD PMID:16891311, PMID:21308733 RGD:10059386, RGD:1625706 NCBI chr37:15,921,214...15,978,492
Ensembl chr37:15,939,138...15,977,556
JBrowse link
G SMAD3 SMAD family member 3 ISO RGD PMID:16891311 RGD:1625706 NCBI chr30:31,246,313...31,360,098
Ensembl chr30:31,245,657...31,363,337
JBrowse link
regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ITGAV integrin subunit alpha V IEA Ensembl GO_REF:0000107 NCBI chr36:28,815,215...28,890,569
Ensembl chr36:28,804,013...28,887,430
JBrowse link
G ITGB6 integrin subunit beta 6 IEA Ensembl GO_REF:0000107 NCBI chr36:5,833,206...5,962,699
Ensembl chr36:5,834,638...5,962,633
JBrowse link
G ITGB8 integrin subunit beta 8 IEA Ensembl GO_REF:0000107 NCBI chr14:34,370,957...34,449,091
Ensembl chr14:34,349,232...34,444,235
JBrowse link
G LRRC32 leucine rich repeat containing 32 ISO (PMID:19651619), (PMID:19750484), (PMID:22278742) UniProt PMID:19651619, PMID:19750484, PMID:22278742 NCBI chr21:22,051,140...22,059,714
Ensembl chr21:22,051,920...22,057,632
JBrowse link
G LTBP1 latent transforming growth factor beta binding protein 1 IEA Ensembl GO_REF:0000107 NCBI chr17:26,129,528...26,521,782
Ensembl chr17:26,130,781...26,521,779
JBrowse link
regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HIF1A hypoxia inducible factor 1 subunit alpha IEA Ensembl GO_REF:0000107 NCBI chr 8:36,614,045...36,656,692
Ensembl chr 8:36,614,045...36,656,692
JBrowse link
G SMAD3 SMAD family member 3 IEA Ensembl GO_REF:0000107 NCBI chr30:31,246,313...31,360,098
Ensembl chr30:31,245,657...31,363,337
JBrowse link
G SMAD4 SMAD family member 4 IEA Ensembl GO_REF:0000107 NCBI chr 1:23,875,989...23,930,027
Ensembl chr 1:23,882,139...23,969,405
JBrowse link
G TGFB2 transforming growth factor beta 2 ISS AgBase GO_REF:0000024 NCBI chr38:13,430,832...13,511,655
Ensembl chr38:13,429,148...13,510,242
JBrowse link
regulation of transforming growth factor beta3 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LRRC32 leucine rich repeat containing 32 IEA Ensembl GO_REF:0000107 NCBI chr21:22,051,140...22,059,714
Ensembl chr21:22,051,920...22,057,632
JBrowse link
transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LTBP3 latent transforming growth factor beta binding protein 3 IEA Ensembl GO_REF:0000107 NCBI chr18:51,653,783...51,667,793
Ensembl chr18:51,659,098...51,667,433
JBrowse link
transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NRROS negative regulator of reactive oxygen species IEA Ensembl GO_REF:0000107 NCBI chr33:29,682,182...29,699,469
Ensembl chr33:29,692,371...29,767,771
JBrowse link
G PIGX phosphatidylinositol glycan anchor biosynthesis class X IEA Ensembl GO_REF:0000107 NCBI chr33:29,740,435...29,767,931
Ensembl chr33:29,692,371...29,767,771
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16187
    multicellular organismal process 7605
      cytokine production 718
        transforming growth factor beta production 45
          negative regulation of transforming growth factor beta production + 15
          positive regulation of transforming growth factor beta production + 20
          regulation of transforming growth factor beta production + 42
          transforming growth factor beta activation + 12
          transforming growth factor beta1 production + 14
          transforming growth factor beta2 production + 8
          transforming growth factor beta3 production + 3
Path 2
Term Annotations click to browse term
  biological_process 16187
    metabolic process 10658
      organic substance metabolic process 10133
        macromolecule metabolic process 8796
          gene expression 5421
            cytokine production 718
              transforming growth factor beta production 45
                negative regulation of transforming growth factor beta production + 15
                positive regulation of transforming growth factor beta production + 20
                regulation of transforming growth factor beta production + 42
                transforming growth factor beta activation + 12
                transforming growth factor beta1 production + 14
                transforming growth factor beta2 production + 8
                transforming growth factor beta3 production + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.