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ONTOLOGY REPORT - ANNOTATIONS


Term:transforming growth factor beta production
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Accession:GO:0071604 term browser browse the term
Definition:The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3.
Synonyms:exact_synonym: TGF-B production;   TGF-beta production;   TGFb production;   TGFbeta production
 narrow_synonym: transforming growth factor-beta secretion
 alt_id: GO:0038044


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transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ITGAV integrin subunit alpha V ISO (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chr 2:186,590,056...186,680,901
Ensembl chr 2:186,590,056...186,680,901
JBrowse link
G ITGB6 integrin subunit beta 6 ISO (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chr 2:160,099,671...160,200,272
Ensembl chr 2:160,099,667...160,200,313
JBrowse link
negative regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR2B activin A receptor type 2B ISO AgBase DOI:10.1016/j.procbio.2011.10.027 NCBI chr 3:38,453,890...38,493,142
Ensembl chr 3:38,453,890...38,493,142
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 IDA (PMID:20599762) UniProtKB PMID:20599762 NCBI chr 6:44,246,194...44,253,883
Ensembl chr 6:44,246,166...44,253,888
JBrowse link
negative regulation of transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FBLN1 fibulin 1 IDA (PMID:25834989) UniProt PMID:25834989 NCBI chr22:45,502,883...45,601,135
Ensembl chr22:45,502,238...45,601,135
JBrowse link
G FN1 fibronectin 1 IDA (PMID:25834989) UniProt PMID:25834989 NCBI chr 2:215,360,862...215,436,167
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G IL13 interleukin 13 IEA Ensembl GO_REF:0000107 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
JBrowse link
G LILRB1 leukocyte immunoglobulin like receptor B1 IDA (PMID:18094328) UniProt PMID:18094328 NCBI chr19:54,616,939...54,637,925
Ensembl chr19:54,617,158...54,637,528
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO (MGI:MGI:5529574|PMID:23994610) MGI PMID:23994610 MGI:MGI:5529574 NCBI chr 7:116,672,196...116,798,386
Ensembl chr 7:116,672,196...116,798,386
JBrowse link
G MIR125A microRNA 125a ISO RGD PMID:29700287 RGD:26884455 NCBI chr19:51,693,254...51,693,339
Ensembl chr19:51,693,254...51,693,339
JBrowse link
negative regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FKBP1A FKBP prolyl isomerase 1A IDA (PMID:11583628) FlyBase PMID:11583628 NCBI chr20:1,368,977...1,393,172
Ensembl chr20:1,368,978...1,393,172
JBrowse link
negative regulation of transforming growth factor beta1 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD2AP CD2 associated protein IEA Ensembl GO_REF:0000107 NCBI chr 6:47,477,746...47,627,263
Ensembl chr 6:47,477,789...47,627,263
JBrowse link
G FURIN furin, paired basic amino acid cleaving enzyme IMP (PMID:15899807) BHF-UCL PMID:15899807 NCBI chr15:90,868,588...90,883,457
Ensembl chr15:90,868,588...90,883,458
JBrowse link
G GATA6 GATA binding protein 6 IMP (PMID:21127043) UniProtKB PMID:21127043 NCBI chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528
JBrowse link
G LAPTM4B lysosomal protein transmembrane 4 beta IDA (PMID:26126825) UniProtKB PMID:26126825 NCBI chr 8:97,775,788...97,853,013
Ensembl chr 8:97,775,057...97,853,013
JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP ISS
IBA
(PMID:21873635) ARUK-UCL
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr19:35,904,403...35,908,295
Ensembl chr19:35,904,401...35,908,295
JBrowse link
negative regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDH3 cadherin 3 IMP (PMID:22696062) UniProtKB PMID:22696062 NCBI chr16:68,644,914...68,727,573
Ensembl chr16:68,636,189...68,722,616
JBrowse link
G GATA6 GATA binding protein 6 IMP (PMID:21127043) UniProtKB PMID:21127043 NCBI chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528
JBrowse link
negative regulation of transforming growth factor beta3 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD24 CD24 molecule IMP (PMID:16930538) UniProtKB PMID:16930538 NCBI chr 6:106,969,831...106,976,855
Ensembl chr 6:106,969,831...106,975,627
JBrowse link
positive regulation of transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD200 CD200 molecule IGI (PMID:26670206) ARUK-UCL PMID:26670206 NCBI chr 3:112,332,573...112,362,812
Ensembl chr 3:112,332,347...112,362,812
JBrowse link
G CD34 CD34 molecule IDA (PMID:17505307) UniProtKB PMID:17505307 NCBI chr 1:207,880,972...207,911,125
Ensembl chr 1:207,880,972...207,911,402
JBrowse link
G CD46 CD46 molecule IDA (PMID:12540904) UniProtKB PMID:12540904 NCBI chr 1:207,752,038...207,795,516
Ensembl chr 1:207,752,057...207,795,513
Ensembl chr 1:207,752,057...207,795,513
JBrowse link
G FERMT1 fermitin family member 1 ISO (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chr20:6,074,845...6,123,609
Ensembl chr20:6,074,845...6,123,030
Ensembl chr20:6,074,845...6,123,030
JBrowse link
G LGALS9 galectin 9 IDA (PMID:20209097) UniProtKB PMID:20209097 NCBI chr17:27,631,172...27,649,560
Ensembl chr17:27,629,798...27,649,560
JBrowse link
G MYB MYB proto-oncogene, transcription factor ISO RGD PMID:15534927 RGD:11532676 NCBI chr 6:135,181,308...135,219,172
Ensembl chr 6:135,181,308...135,219,173
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISS (PMID:9630216) BHF-UCL PMID:9630216 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G SERPINF2 serpin family F member 2 IDA (PMID:17958745), (PMID:20008146) BHF-UCL PMID:17958745, PMID:20008146 NCBI chr17:1,742,808...1,755,265
Ensembl chr17:1,742,836...1,755,265
Ensembl chr17:1,742,836...1,755,265
JBrowse link
G THBS1 thrombospondin 1 ISO RGD PMID:17640965 RGD:2317942 NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466
JBrowse link
G XCL1 X-C motif chemokine ligand 1 IDA (PMID:18832695) BHF-UCL PMID:18832695 NCBI chr 1:168,574,128...168,582,069
Ensembl chr 1:168,576,605...168,582,069
JBrowse link
positive regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FURIN furin, paired basic amino acid cleaving enzyme IDA (PMID:7737999) UniProt PMID:7737999 NCBI chr15:90,868,588...90,883,457
Ensembl chr15:90,868,588...90,883,458
JBrowse link
positive regulation of transforming growth factor beta1 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP6AP2 ATPase H+ transporting accessory protein 2 IDA (PMID:16374430) HGNC PMID:16374430 NCBI chr  X:40,580,970...40,606,848
Ensembl chr  X:40,579,372...40,606,848
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 IEA Ensembl GO_REF:0000107 NCBI chr16:57,372,490...57,385,044
Ensembl chr16:57,372,477...57,385,044
JBrowse link
G FOXP3 forkhead box P3 IEA Ensembl GO_REF:0000107 NCBI chr  X:49,250,436...49,264,932
Ensembl chr  X:49,250,438...49,270,477
Ensembl chr  X:49,250,438...49,270,477
JBrowse link
G LUM lumican IEA Ensembl GO_REF:0000107 NCBI chr12:91,102,629...91,111,494
Ensembl chr12:91,102,629...91,111,494
JBrowse link
G SERPINB7 serpin family B member 7 IEA Ensembl GO_REF:0000107 NCBI chr18:63,753,057...63,805,370
Ensembl chr18:63,752,935...63,805,376
JBrowse link
G THBS1 thrombospondin 1 ISS BHF-UCL GO_REF:0000024 NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466
JBrowse link
positive regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF2 activating transcription factor 2 IEA Ensembl GO_REF:0000107 NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382
JBrowse link
G WNT11 Wnt family member 11 IEA Ensembl GO_REF:0000107 NCBI chr11:76,186,325...76,210,842
Ensembl chr11:76,186,325...76,210,736
JBrowse link
positive regulation of transforming growth factor beta3 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CREB1 cAMP responsive element binding protein 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G SMAD3 SMAD family member 3 IEA Ensembl GO_REF:0000107 NCBI chr15:67,065,602...67,195,195
Ensembl chr15:67,063,763...67,195,169
JBrowse link
regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ITGAV integrin subunit alpha V IDA (PMID:22278742) UniProt PMID:22278742 NCBI chr 2:186,590,056...186,680,901
Ensembl chr 2:186,590,056...186,680,901
JBrowse link
G ITGB6 integrin subunit beta 6 IDA (PMID:22278742) UniProt PMID:22278742 NCBI chr 2:160,099,671...160,200,272
Ensembl chr 2:160,099,667...160,200,313
JBrowse link
G ITGB8 integrin subunit beta 8 ISS UniProt GO_REF:0000024 NCBI chr 7:20,329,819...20,415,754
Ensembl chr 7:20,330,702...20,415,754
JBrowse link
G LRRC32 leucine rich repeat containing 32 IDA (PMID:19651619), (PMID:19750484), (PMID:22278742) UniProt PMID:19651619, PMID:19750484, PMID:22278742 NCBI chr11:76,657,524...76,670,747
Ensembl chr11:76,657,524...76,670,747
JBrowse link
G LTBP1 latent transforming growth factor beta binding protein 1 IDA (PMID:2022183), (PMID:8617200) UniProt PMID:2022183, PMID:8617200 NCBI chr 2:32,902,129...33,399,509
Ensembl chr 2:32,946,953...33,399,509
JBrowse link
regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HIF1A hypoxia inducible factor 1 subunit alpha IMP (PMID:12411310) BHF-UCL PMID:12411310 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G SMAD3 SMAD family member 3 IMP (PMID:12411310) BHF-UCL PMID:12411310 NCBI chr15:67,065,602...67,195,195
Ensembl chr15:67,063,763...67,195,169
JBrowse link
G SMAD4 SMAD family member 4 IMP (PMID:12411310) BHF-UCL PMID:12411310 NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,394...51,085,045
JBrowse link
G TGFB2 transforming growth factor beta 2 IMP (PMID:12411310) BHF-UCL PMID:12411310 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
regulation of transforming growth factor beta3 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LRRC32 leucine rich repeat containing 32 IEA Ensembl GO_REF:0000107 NCBI chr11:76,657,524...76,670,747
Ensembl chr11:76,657,524...76,670,747
JBrowse link
transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LTBP3 latent transforming growth factor beta binding protein 3 IMP (PMID:18672106) UniProtKB PMID:18672106 NCBI chr11:65,538,559...65,558,389
Ensembl chr11:65,538,805...65,558,930
JBrowse link
transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NRROS negative regulator of reactive oxygen species ISS UniProt GO_REF:0000024 NCBI chr 3:196,639,694...196,662,004
Ensembl chr 3:196,639,694...196,662,004
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18670
    multicellular organismal process 8796
      cytokine production 904
        transforming growth factor beta production 45
          negative regulation of transforming growth factor beta production + 16
          positive regulation of transforming growth factor beta production + 20
          regulation of transforming growth factor beta production + 43
          transforming growth factor beta activation + 11
          transforming growth factor beta1 production + 13
          transforming growth factor beta2 production + 8
          transforming growth factor beta3 production + 4
Path 2
Term Annotations click to browse term
  biological_process 18670
    metabolic process 12302
      organic substance metabolic process 11737
        macromolecule metabolic process 10194
          gene expression 6340
            cytokine production 904
              transforming growth factor beta production 45
                negative regulation of transforming growth factor beta production + 16
                positive regulation of transforming growth factor beta production + 20
                regulation of transforming growth factor beta production + 43
                transforming growth factor beta activation + 11
                transforming growth factor beta1 production + 13
                transforming growth factor beta2 production + 8
                transforming growth factor beta3 production + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.