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ONTOLOGY REPORT - ANNOTATIONS


Term:transforming growth factor beta production
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Accession:GO:0071604 term browser browse the term
Definition:The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3.
Synonyms:exact_synonym: TGF-B production;   TGF-beta production;   TGFb production;   TGFbeta production
 narrow_synonym: transforming growth factor-beta secretion
 alt_id: GO:0038044


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transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgav integrin alpha V IDA (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chr 2:83,722,303...83,806,917
Ensembl chr 2:83,724,397...83,806,916
JBrowse link
G Itgb6 integrin beta 6 IDA (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chr 2:60,598,292...60,722,603
Ensembl chr 2:60,598,292...60,722,643
JBrowse link
negative regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2b activin receptor IIB ISO AgBase DOI:10.1016/j.procbio.2011.10.027 NCBI chr 9:119,401,583...119,442,148
Ensembl chr 9:119,402,118...119,434,995
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr17:45,567,778...45,573,261
Ensembl chr17:45,567,775...45,573,271
JBrowse link
negative regulation of transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbln1 fibulin 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr15:85,205,949...85,286,294
Ensembl chr15:85,205,949...85,286,535
JBrowse link
G Fn1 fibronectin 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200
JBrowse link
G Il13 interleukin 13 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr11:53,631,323...53,634,702
Ensembl chr11:53,631,324...53,634,702
JBrowse link
G Met met proto-oncogene IMP (MGI:MGI:5529574|PMID:23994610) MGI PMID:23994610 MGI:MGI:5529574 NCBI chr 6:17,463,349...17,573,980
Ensembl chr 6:17,463,800...17,573,980
JBrowse link
G Mir125a microRNA 125a ISO RGD PMID:29700287 RGD:26884455 NCBI chr17:17,830,812...17,830,879
Ensembl chr17:17,830,812...17,830,879
JBrowse link
negative regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fkbp1a FK506 binding protein 1a ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 2:151,542,483...151,561,691
Ensembl chr 2:151,542,483...151,561,692
JBrowse link
negative regulation of transforming growth factor beta1 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd2ap CD2-associated protein IGI (MGI:MGI:5297732|PMID:21911934) MGI PMID:21911934 MGI:MGI:5297732 NCBI chr17:42,748,887...42,876,707
Ensembl chr17:42,792,951...42,876,665
JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 7:80,389,194...80,405,441
Ensembl chr 7:80,388,585...80,405,436
JBrowse link
G Gata6 GATA binding protein 6 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr18:11,052,510...11,085,636
Ensembl chr18:11,052,064...11,085,635
JBrowse link
G Laptm4b lysosomal-associated protein transmembrane 4B ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr15:34,238,026...34,284,295
Ensembl chr15:34,238,028...34,284,302
JBrowse link
G Tyrobp TYRO protein tyrosine kinase binding protein IMP
IBA
(MGI:MGI:5638298|PMID:25690660)
(MGI:MGI:6201960|PMID:21873635)
ARUK-UCL
GO_Central
PMID:21873635, PMID:25690660 MGI:MGI:5638298, MGI:MGI:6201960 NCBI chr 7:30,413,782...30,417,582
Ensembl chr 7:30,413,760...30,417,585
JBrowse link
negative regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh3 cadherin 3 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 8:106,510,852...106,556,911
Ensembl chr 8:106,510,891...106,557,297
JBrowse link
G Gata6 GATA binding protein 6 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr18:11,052,510...11,085,636
Ensembl chr18:11,052,064...11,085,635
JBrowse link
negative regulation of transforming growth factor beta3 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd24a CD24a antigen ISS (MGI:MGI:3759334|PMID:16930538) UniProtKB PMID:16930538 MGI:MGI:3759334 NCBI chr10:43,579,169...43,584,265
Ensembl chr10:43,578,284...43,584,265
JBrowse link
positive regulation of transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd200 CD200 antigen ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr16:45,382,111...45,409,060
Ensembl chr16:45,382,135...45,409,053
JBrowse link
G Cd34 CD34 antigen ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 1:194,938,821...194,961,292
Ensembl chr 1:194,938,819...194,961,279
JBrowse link
G Cd46 CD46 antigen, complement regulatory protein ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 1:195,038,971...195,098,784
Ensembl chr 1:195,036,826...195,092,249
JBrowse link
G Fermt1 fermitin family member 1 IMP (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chr 2:132,904,177...132,946,036
Ensembl chr 2:132,904,389...132,945,906
JBrowse link
G Lgals9 lectin, galactose binding, soluble 9 ISO (PMID:20209097) UniProtKB PMID:20209097 NCBI chr11:78,962,979...78,984,924
Ensembl chr11:78,962,974...78,984,946
JBrowse link
G Myb myeloblastosis oncogene ISO RGD PMID:15534927 RGD:11532676 NCBI chr10:21,124,930...21,160,984
Ensembl chr10:21,124,935...21,160,984
JBrowse link
G Psg22 pregnancy-specific glycoprotein 22 IDA (MGI:MGI:5430265|PMID:22423048) MGI PMID:22423048 MGI:MGI:5430265 NCBI chr 7:18,718,051...18,727,438
Ensembl chr 7:18,718,090...18,727,248
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Serpinf2 serine (or cysteine) peptidase inhibitor, clade F, member 2 IMP
ISO
(MGI:MGI:5306295|PMID:17958745) BHF-UCL
MGI
PMID:17958745 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:5306295 NCBI chr11:75,431,736...75,439,501
Ensembl chr11:75,431,732...75,439,591
JBrowse link
G Thbs1 thrombospondin 1 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr 2:118,111,876...118,127,133
Ensembl chr 2:118,111,876...118,127,133
JBrowse link
G Xcl1 chemokine (C motif) ligand 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 1:164,931,644...164,935,522
Ensembl chr 1:164,931,644...164,935,527
JBrowse link
positive regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Furin furin (paired basic amino acid cleaving enzyme) ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 7:80,389,194...80,405,441
Ensembl chr 7:80,388,585...80,405,436
JBrowse link
positive regulation of transforming growth factor beta1 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr  X:12,587,759...12,617,051
Ensembl chr  X:12,587,801...12,617,049
JBrowse link
G Cx3cl1 chemokine (C-X3-C motif) ligand 1 IMP (MGI:MGI:3772530|PMID:18097059) MGI PMID:18097059 MGI:MGI:3772530 NCBI chr 8:94,772,180...94,782,427
Ensembl chr 8:94,772,009...94,782,427
JBrowse link
G Foxp3 forkhead box P3 IDA (MGI:MGI:3697020|PMID:17028180) MGI PMID:17028180 MGI:MGI:3697020 NCBI chr  X:7,579,676...7,595,243
Ensembl chr  X:7,573,644...7,595,245
JBrowse link
G Lum lumican IMP (MGI:MGI:5295830|PMID:21931815) CACAO PMID:21931815 MGI:MGI:5295830 NCBI chr10:97,565,501...97,572,703
Ensembl chr10:97,565,128...97,572,703
JBrowse link
G Serpinb7 serine (or cysteine) peptidase inhibitor, clade B, member 7 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr 1:107,422,689...107,452,689
Ensembl chr 1:107,399,655...107,452,689
JBrowse link
positive regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 IMP (MGI:MGI:3759355|PMID:17767158) MGI PMID:17767158 MGI:MGI:3759355 NCBI chr 2:73,816,509...73,892,677
Ensembl chr 2:73,816,509...73,892,639
JBrowse link
G Wnt11 wingless-type MMTV integration site family, member 11 IMP (MGI:MGI:3759355|PMID:17767158) MGI PMID:17767158 MGI:MGI:3759355 NCBI chr 7:98,835,084...98,854,747
Ensembl chr 7:98,835,112...98,855,195
JBrowse link
positive regulation of transforming growth factor beta3 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creb1 cAMP responsive element binding protein 1 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Smad3 SMAD family member 3 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr 9:63,646,766...63,757,994
Ensembl chr 9:63,646,767...63,757,994
JBrowse link
regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgav integrin alpha V ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 2:83,722,303...83,806,917
Ensembl chr 2:83,724,397...83,806,916
JBrowse link
G Itgb6 integrin beta 6 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 2:60,598,292...60,722,603
Ensembl chr 2:60,598,292...60,722,643
JBrowse link
G Itgb8 integrin beta 8 IDA (MGI:MGI:5490445|PMID:22278742) UniProt PMID:22278742 MGI:MGI:5490445 NCBI chr12:119,162,803...119,238,276
Ensembl chr12:119,158,022...119,238,802
JBrowse link
G Lrrc32 leucine rich repeat containing 32 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 7:98,489,305...98,501,831
Ensembl chr 7:98,489,283...98,502,181
JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr17:75,005,480...75,392,512
Ensembl chr17:75,005,568...75,392,512
JBrowse link
regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hif1a hypoxia inducible factor 1, alpha subunit ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Smad3 SMAD family member 3 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 9:63,646,766...63,757,994
Ensembl chr 9:63,646,767...63,757,994
JBrowse link
G Smad4 SMAD family member 4 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr18:73,634,790...73,703,791
Ensembl chr18:73,639,009...73,703,780
JBrowse link
G Tgfb2 transforming growth factor, beta 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 1:186,622,787...186,709,697
Ensembl chr 1:186,622,792...186,705,989
JBrowse link
regulation of transforming growth factor beta3 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrc32 leucine rich repeat containing 32 IDA (MGI:MGI:5920420|PMID:28912269) UniProt PMID:28912269 MGI:MGI:5920420 NCBI chr 7:98,489,305...98,501,831
Ensembl chr 7:98,489,283...98,502,181
JBrowse link
transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ltbp3 latent transforming growth factor beta binding protein 3 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr19:5,740,900...5,758,536
Ensembl chr19:5,740,904...5,758,532
JBrowse link
transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nrros negative regulator of reactive oxygen species IDA (MGI:MGI:6192878|PMID:29909984) UniProt PMID:29909984 MGI:MGI:6192878 NCBI chr16:32,142,785...32,165,594
Ensembl chr16:32,142,785...32,165,594
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23386
    multicellular organismal process 8908
      cytokine production 843
        transforming growth factor beta production 45
          negative regulation of transforming growth factor beta production + 15
          positive regulation of transforming growth factor beta production + 21
          regulation of transforming growth factor beta production + 43
          transforming growth factor beta activation + 11
          transforming growth factor beta1 production + 12
          transforming growth factor beta2 production + 8
          transforming growth factor beta3 production + 4
Path 2
Term Annotations click to browse term
  biological_process 23386
    metabolic process 11301
      organic substance metabolic process 10764
        macromolecule metabolic process 9284
          gene expression 5856
            cytokine production 843
              transforming growth factor beta production 45
                negative regulation of transforming growth factor beta production + 15
                positive regulation of transforming growth factor beta production + 21
                regulation of transforming growth factor beta production + 43
                transforming growth factor beta activation + 11
                transforming growth factor beta1 production + 12
                transforming growth factor beta2 production + 8
                transforming growth factor beta3 production + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.