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ONTOLOGY REPORT - ANNOTATIONS


Term:transforming growth factor beta production
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Accession:GO:0071604 term browser browse the term
Definition:The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3.
Synonyms:exact_synonym: TGF-B production;   TGF-beta production;   TGFb production;   TGFbeta production
 narrow_synonym: transforming growth factor-beta secretion
 alt_id: GO:0038044


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transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ITGAV integrin subunit alpha V ISO (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chr15:91,604,666...91,711,843
Ensembl chr15:91,604,676...91,711,840
JBrowse link
G ITGB6 integrin subunit beta 6 ISO (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chr15:67,041,516...67,175,409
Ensembl chr15:67,041,519...67,175,234
JBrowse link
negative regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR2B activin A receptor type 2B IMP AgBase DOI:10.1016/j.procbio.2011.10.027 NCBI chr13:23,237,699...23,276,086
Ensembl chr13:23,237,699...23,267,382
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 IEA Ensembl GO_REF:0000107 NCBI chr 7:39,237,299...39,250,479
Ensembl chr 7:39,244,458...39,254,002
JBrowse link
negative regulation of transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FBLN1 fibulin 1 ISO (PMID:25834989) UniProt PMID:25834989 NCBI chr 5:3,839,498...3,927,178
Ensembl chr 5:3,839,501...3,927,183
JBrowse link
G FN1 fibronectin 1 ISO (PMID:25834989) UniProt PMID:25834989 NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,014
JBrowse link
G IL13 interleukin 13 ISO RGD PMID:20100461 RGD:4145466 NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO (MGI:MGI:5529574|PMID:23994610) MGI PMID:23994610 MGI:MGI:5529574 NCBI chr18:29,426,044...29,541,526
Ensembl chr18:29,426,044...29,541,512
JBrowse link
G MIR125A microRNA mir-125a ISO RGD PMID:29700287 RGD:26884455 NCBI chr 6:58,331,566...58,331,645
Ensembl chr 6:58,331,566...58,331,645
JBrowse link
negative regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FKBP1A FKBP prolyl isomerase 1A ISO (PMID:11583628) FlyBase PMID:11583628 NCBI chr17:33,910,047...33,935,212 JBrowse link
negative regulation of transforming growth factor beta1 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD2AP CD2 associated protein IEA Ensembl GO_REF:0000107 NCBI chr 7:42,218,016...42,332,523
Ensembl chr 7:42,217,588...42,332,518
JBrowse link
G FURIN furin, paired basic amino acid cleaving enzyme IEA Ensembl GO_REF:0000107 NCBI chr 7:53,455,634...53,472,791
Ensembl chr 7:53,460,017...53,472,790
JBrowse link
G GATA6 GATA binding protein 6 IEA Ensembl GO_REF:0000107 NCBI chr 6:107,282,709...107,314,725
Ensembl chr 6:107,282,847...107,314,634
JBrowse link
G LAPTM4B lysosomal protein transmembrane 4 beta IEA Ensembl GO_REF:0000107 NCBI chr 4:38,932,735...39,015,219
Ensembl chr 4:38,932,736...39,023,925
JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 6:45,309,199...45,312,562
Ensembl chr 6:45,309,197...45,312,537
JBrowse link
negative regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDH3 cadherin 3 IEA Ensembl GO_REF:0000107 NCBI chr 6:18,190,971...18,236,184
Ensembl chr 6:18,191,664...18,235,862
JBrowse link
G GATA6 GATA binding protein 6 IEA Ensembl GO_REF:0000107 NCBI chr 6:107,282,709...107,314,725
Ensembl chr 6:107,282,847...107,314,634
JBrowse link
negative regulation of transforming growth factor beta3 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100519934 uncharacterized LOC100519934 ISO (PMID:16930538) UniProtKB PMID:16930538 NCBI chr 1:73,119,758...73,124,368 JBrowse link
positive regulation of transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD200 CD200 molecule IEA Ensembl GO_REF:0000107 NCBI chr13:147,465,858...147,485,818
Ensembl chr13:147,465,863...147,522,836
JBrowse link
G CD34 CD34 molecule IEA Ensembl GO_REF:0000107 NCBI chr 9:134,912,793...134,937,763
Ensembl chr 9:134,913,121...134,937,762
JBrowse link
G CD46 CD46 molecule, complement regulatory protein ISO (PMID:12540904) UniProtKB PMID:12540904 NCBI chr 9:135,025,439...135,078,910 JBrowse link
G FERMT1 fermitin family member 1 ISO (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chr17:15,080,585...15,137,947
Ensembl chr17:15,080,587...15,137,753
JBrowse link
G LGALS9 galectin 9 ISO (PMID:20209097) UniProtKB PMID:20209097 NCBI chr12:44,155,079...44,173,634 JBrowse link
G MYB MYB proto-oncogene, transcription factor ISO RGD PMID:15534927 RGD:11532676 NCBI chr 1:28,819,500...28,856,222
Ensembl chr 1:28,819,503...28,857,000
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO PMID:9630216 BHF-UCL PMID:9630216 RGD:5135054 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
G SERPINF2 serpin family F member 2 IEA Ensembl GO_REF:0000107 NCBI chr12:47,934,551...47,942,283
Ensembl chr12:47,933,864...47,942,287
JBrowse link
G THBS1 thrombospondin 1 ISO RGD PMID:17640965 RGD:2317942 NCBI chr 1:131,728,781...131,746,098
Ensembl chr 1:131,728,781...131,746,115
JBrowse link
G XCL1 chemokine (C motif) ligand 1 ISO (PMID:18832695) BHF-UCL PMID:18832695 NCBI chr 4:82,432,845...82,436,150
Ensembl chr 4:82,432,198...82,436,180
JBrowse link
positive regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FURIN furin, paired basic amino acid cleaving enzyme IEA Ensembl GO_REF:0000107 NCBI chr 7:53,455,634...53,472,791
Ensembl chr 7:53,460,017...53,472,790
JBrowse link
positive regulation of transforming growth factor beta1 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP6AP2 ATPase H+ transporting accessory protein 2 IEA Ensembl GO_REF:0000107 NCBI chr  X:36,271,154...36,300,240
Ensembl chr  X:36,271,223...36,304,183
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 ISO (MGI:MGI:3772530|PMID:18097059) MGI PMID:18097059 MGI:MGI:3772530 NCBI chr 6:19,312,351...19,324,439 JBrowse link
G FOXP3 forkhead box P3 IEA Ensembl GO_REF:0000107 NCBI chr  X:43,303,777...43,328,164
Ensembl chr  X:43,303,782...43,328,735
JBrowse link
G LUM lumican IEA Ensembl GO_REF:0000107 NCBI chr 5:91,748,871...91,756,381
Ensembl chr 5:91,748,885...91,757,615
JBrowse link
G SERPINB7 serpin family B member 7 ISO RGD PMID:21945418 RGD:7207383 NCBI chr 1:157,953,872...157,999,242
Ensembl chr 1:157,953,870...157,998,842
JBrowse link
positive regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF2 activating transcription factor 2 IEA Ensembl GO_REF:0000107 NCBI chr15:80,984,969...81,076,573
Ensembl chr15:80,984,977...81,091,532
JBrowse link
G WNT11 Wnt family member 11 IEA Ensembl GO_REF:0000107 NCBI chr 9:10,413,182...10,435,158
Ensembl chr 9:10,413,187...10,435,100
JBrowse link
positive regulation of transforming growth factor beta3 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CREB1 cAMP responsive element binding protein 1 ISO RGD PMID:16891311, PMID:21308733 RGD:10059386, RGD:1625706 NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,697,408...110,771,755
JBrowse link
G SMAD3 SMAD family member 3 ISO RGD PMID:16891311 RGD:1625706 NCBI chr 1:164,998,457...165,124,455
Ensembl chr 1:164,998,083...165,124,454
JBrowse link
regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ITGAV integrin subunit alpha V IEA Ensembl GO_REF:0000107 NCBI chr15:91,604,666...91,711,843
Ensembl chr15:91,604,676...91,711,840
JBrowse link
G ITGB6 integrin subunit beta 6 ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr15:67,041,516...67,175,409
Ensembl chr15:67,041,519...67,175,234
JBrowse link
G ITGB8 integrin subunit beta 8 IEA Ensembl GO_REF:0000107 NCBI chr 9:89,342,245...89,450,701
Ensembl chr 9:89,341,141...89,450,679
JBrowse link
G LRRC32 leucine rich repeat containing 32 ISO (PMID:19651619), (PMID:19750484), (PMID:22278742) UniProt PMID:19651619, PMID:19750484, PMID:22278742 NCBI chr 9:10,802,228...10,815,892
Ensembl chr 9:10,801,946...10,817,930
JBrowse link
G LTBP1 latent transforming growth factor beta binding protein 1 IEA Ensembl GO_REF:0000107 NCBI chr 3:106,300,748...106,724,538
Ensembl chr 3:106,300,750...106,724,934
JBrowse link
regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HIF1A hypoxia inducible factor 1 subunit alpha IEA Ensembl GO_REF:0000107 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,181...190,674,850
JBrowse link
G SMAD3 SMAD family member 3 IEA Ensembl GO_REF:0000107 NCBI chr 1:164,998,457...165,124,455
Ensembl chr 1:164,998,083...165,124,454
JBrowse link
G SMAD4 SMAD family member 4 IEA Ensembl GO_REF:0000107 NCBI chr 1:100,521,843...100,633,501
Ensembl chr 1:100,514,791...100,628,029
JBrowse link
G TGFB2 transforming growth factor beta 2 ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,424...8,405,771
JBrowse link
regulation of transforming growth factor beta3 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LRRC32 leucine rich repeat containing 32 IEA Ensembl GO_REF:0000107 NCBI chr 9:10,802,228...10,815,892
Ensembl chr 9:10,801,946...10,817,930
JBrowse link
transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LTBP3 latent transforming growth factor beta binding protein 3 IEA Ensembl GO_REF:0000107 NCBI chr 2:6,701,455...6,720,191
Ensembl chr 2:6,701,340...6,720,172
JBrowse link
transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NRROS negative regulator of reactive oxygen species IEA Ensembl GO_REF:0000107 NCBI chr13:133,470,641...133,496,218
Ensembl chr13:133,470,643...133,496,264
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16545
    multicellular organismal process 8059
      cytokine production 784
        transforming growth factor beta production 44
          negative regulation of transforming growth factor beta production + 15
          positive regulation of transforming growth factor beta production + 20
          regulation of transforming growth factor beta production + 42
          transforming growth factor beta activation + 11
          transforming growth factor beta1 production + 12
          transforming growth factor beta2 production + 8
          transforming growth factor beta3 production + 4
Path 2
Term Annotations click to browse term
  biological_process 16545
    metabolic process 10588
      organic substance metabolic process 10037
        macromolecule metabolic process 8724
          gene expression 5316
            cytokine production 784
              transforming growth factor beta production 44
                negative regulation of transforming growth factor beta production + 15
                positive regulation of transforming growth factor beta production + 20
                regulation of transforming growth factor beta production + 42
                transforming growth factor beta activation + 11
                transforming growth factor beta1 production + 12
                transforming growth factor beta2 production + 8
                transforming growth factor beta3 production + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.