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ONTOLOGY REPORT - ANNOTATIONS


Term:transforming growth factor beta production
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Accession:GO:0071604 term browser browse the term
Definition:The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3.
Synonyms:exact_synonym: TGF-B production;   TGF-beta production;   TGFb production;   TGFbeta production
 narrow_synonym: transforming growth factor-beta secretion
 alt_id: GO:0038044


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transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgav integrin subunit alpha V ISO (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chrNW_004936506:10,750,116...10,839,018 JBrowse link
G Itgb6 integrin subunit beta 6 ISO (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chrNW_004936469:18,581,855...18,650,109 JBrowse link
negative regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2b activin A receptor type 2B ISO AgBase DOI:10.1016/j.procbio.2011.10.027 NCBI chrNW_004936473:27,816,366...27,822,555 JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISO (PMID:20599762) UniProtKB PMID:20599762 NCBI chrNW_004936476:15,830,459...15,836,994 JBrowse link
negative regulation of transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbln1 fibulin 1 ISO (PMID:25834989) UniProt PMID:25834989 NCBI chrNW_004936629:4,170,186...4,242,100 JBrowse link
G Fn1 fibronectin 1 ISO (PMID:25834989) UniProt PMID:25834989 NCBI chrNW_004936586:1,708,803...1,773,372 JBrowse link
G Il13 interleukin 13 ISO RGD PMID:20100461 RGD:4145466 NCBI chrNW_004936647:2,529,933...2,532,503 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO (MGI:MGI:5529574|PMID:23994610) MGI PMID:23994610 MGI:MGI:5529574 NCBI chrNW_004936589:2,280,803...2,390,179 JBrowse link
negative regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fkbp1a FKBP prolyl isomerase 1A ISO (PMID:11583628) FlyBase PMID:11583628 NCBI chrNW_004936485:17,305,376...17,311,797 JBrowse link
negative regulation of transforming growth factor beta1 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd2ap CD2 associated protein ISO (MGI:MGI:5297732|PMID:21911934) MGI PMID:21911934 MGI:MGI:5297732 NCBI chrNW_004936476:12,890,595...12,989,046 JBrowse link
G Furin furin, paired basic amino acid cleaving enzyme ISO (PMID:15899807) BHF-UCL PMID:15899807 NCBI chrNW_004936483:16,136,099...16,147,945 JBrowse link
G Gata6 GATA binding protein 6 ISO (PMID:21127043) UniProtKB PMID:21127043 NCBI chrNW_004936550:1,814,336...1,844,399 JBrowse link
G Laptm4b lysosomal protein transmembrane 4 beta ISO (PMID:26126825) UniProtKB PMID:26126825 NCBI chrNW_004936470:44,917,462...44,981,773 JBrowse link
G Tyrobp transmembrane immune signaling adaptor TYROBP ISO (MGI:MGI:5638298|PMID:25690660) ARUK-UCL PMID:25690660 MGI:MGI:5638298 NCBI chrNW_004936570:457,993...460,735 JBrowse link
negative regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh3 cadherin 3 ISO (PMID:22696062) UniProtKB PMID:22696062 NCBI chrNW_004936475:18,908,031...18,954,402 JBrowse link
G Gata6 GATA binding protein 6 ISO (PMID:21127043) UniProtKB PMID:21127043 NCBI chrNW_004936550:1,814,336...1,844,399 JBrowse link
negative regulation of transforming growth factor beta3 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101968601 signal transducer CD24 ISO (PMID:16930538) UniProtKB PMID:16930538 NCBI chrNW_004936491:16,706,745...16,707,010 JBrowse link
positive regulation of transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd200 CD200 molecule ISO (PMID:26670206) ARUK-UCL PMID:26670206 NCBI chrNW_004936536:8,337...33,954 JBrowse link
G Cd34 CD34 molecule ISO (PMID:17505307) UniProtKB PMID:17505307 NCBI chrNW_004936557:5,030,788...5,051,864 JBrowse link
G Cd46 CD46 molecule ISO (PMID:12540904) UniProtKB PMID:12540904 NCBI chrNW_004936557:5,136,784...5,175,543 JBrowse link
G Fermt1 fermitin family member 1 ISO (MGI:MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:MGI:5571208 NCBI chrNW_004936485:12,985,552...13,016,997 JBrowse link
G Lgals9 galectin 9 ISO (PMID:20209097) UniProtKB PMID:20209097 NCBI chrNW_004936538:4,034,467...4,050,240 JBrowse link
G LOC101970885 lymphotactin ISO (PMID:18832695) BHF-UCL PMID:18832695 NCBI chrNW_004936481:17,825,714...17,828,955 JBrowse link
G Myb MYB proto-oncogene, transcription factor ISO RGD PMID:15534927 RGD:11532676 NCBI chrNW_004936560:2,797,943...2,828,813 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO PMID:9630216 BHF-UCL PMID:9630216 RGD:5135054 NCBI chrNW_004936481:3,821,564...3,828,086 JBrowse link
G Serpinf2 serpin family F member 2 ISO (PMID:17958745), (PMID:20008146)
(MGI:MGI:5306295|PMID:17958745)
BHF-UCL PMID:17958745, PMID:20008146 MGI:MGI:5306295 NCBI chrNW_004936538:7,870,898...7,877,279 JBrowse link
G Thbs1 thrombospondin 1 ISO RGD PMID:17640965 RGD:2317942 NCBI chrNW_004936471:3,064,466...3,081,125 JBrowse link
positive regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Furin furin, paired basic amino acid cleaving enzyme ISO (PMID:7737999) UniProt PMID:7737999 NCBI chrNW_004936483:16,136,099...16,147,945 JBrowse link
positive regulation of transforming growth factor beta1 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap2 ATPase H+ transporting accessory protein 2 ISO (PMID:16374430) HGNC PMID:16374430 NCBI chrNW_004936502:7,206,226...7,232,798 JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO (MGI:MGI:3772530|PMID:18097059) MGI PMID:18097059 MGI:MGI:3772530 NCBI chrNW_004936475:9,443,851...9,454,715 JBrowse link
G Foxp3 forkhead box P3 ISO (MGI:MGI:3697020|PMID:17028180) MGI PMID:17028180 MGI:MGI:3697020 NCBI chrNW_004936721:1,118,376...1,125,282 JBrowse link
G Lum lumican ISO (MGI:MGI:5295830|PMID:21931815) CACAO PMID:21931815 MGI:MGI:5295830 NCBI chrNW_004936507:7,847,761...7,855,311 JBrowse link
G Serpinb7 serpin family B member 7 ISO RGD PMID:21945418 RGD:7207383 NCBI chrNW_004936497:1,865,540...1,887,695 JBrowse link
positive regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 ISO (MGI:MGI:3759355|PMID:17767158) MGI PMID:17767158 MGI:MGI:3759355 NCBI chrNW_004936509:4,729,984...4,826,367 JBrowse link
G Wnt11 Wnt family member 11 ISO (MGI:MGI:3759355|PMID:17767158) MGI PMID:17767158 MGI:MGI:3759355 NCBI chrNW_004936498:4,909,041...4,927,482 JBrowse link
positive regulation of transforming growth factor beta3 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creb1 cAMP responsive element binding protein 1 ISO RGD PMID:16891311, PMID:21308733 RGD:10059386, RGD:1625706 NCBI chrNW_004936631:3,721,307...3,785,346 JBrowse link
G Smad3 SMAD family member 3 ISO RGD PMID:16891311 RGD:1625706 NCBI chrNW_004936471:27,080,662...27,185,861 JBrowse link
regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgav integrin subunit alpha V ISO (PMID:22278742) UniProt PMID:22278742 NCBI chrNW_004936506:10,750,116...10,839,018 JBrowse link
G Itgb6 integrin subunit beta 6 ISO (PMID:22278742) UniProt PMID:22278742 NCBI chrNW_004936469:18,581,855...18,650,109 JBrowse link
G Itgb8 integrin subunit beta 8 ISO (MGI:MGI:5490445|PMID:22278742) UniProt PMID:22278742 MGI:MGI:5490445 NCBI chrNW_004936546:6,352,186...6,447,458 JBrowse link
G Lrrc32 leucine rich repeat containing 32 ISO (PMID:19651619), (PMID:19750484), (PMID:22278742) UniProt PMID:19651619, PMID:19750484, PMID:22278742 NCBI chrNW_004936498:5,305,680...5,315,580 JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 ISO (PMID:2022183), (PMID:8617200) UniProt PMID:2022183, PMID:8617200 NCBI chrNW_004936493:253,390...640,140 JBrowse link
regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hif1a hypoxia inducible factor 1 subunit alpha ISO (PMID:12411310) BHF-UCL PMID:12411310 NCBI chrNW_004936495:5,770,988...5,816,157 JBrowse link
G Smad3 SMAD family member 3 ISO (PMID:12411310) BHF-UCL PMID:12411310 NCBI chrNW_004936471:27,080,662...27,185,861 JBrowse link
G Smad4 SMAD family member 4 ISO (PMID:12411310) BHF-UCL PMID:12411310 NCBI chrNW_004936497:12,242,869...12,278,012 JBrowse link
G Tgfb2 transforming growth factor beta 2 ISO (PMID:12411310) BHF-UCL PMID:12411310 NCBI chrNW_004936628:310,720...394,002 JBrowse link
regulation of transforming growth factor beta3 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrc32 leucine rich repeat containing 32 ISO (MGI:MGI:5920420|PMID:28912269) UniProt PMID:28912269 MGI:MGI:5920420 NCBI chrNW_004936498:5,305,680...5,315,580 JBrowse link
transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ltbp3 latent transforming growth factor beta binding protein 3 ISO (PMID:18672106) UniProtKB PMID:18672106 NCBI chrNW_004936599:3,902,903...3,918,471 JBrowse link
transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nrros negative regulator of reactive oxygen species ISO (MGI:MGI:6192878|PMID:29909984) UniProt PMID:29909984 MGI:MGI:6192878 NCBI chrNW_004936784:1,222,381...1,250,501 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11998
    multicellular organismal process 6221
      cytokine production 647
        transforming growth factor beta production 43
          negative regulation of transforming growth factor beta production + 14
          positive regulation of transforming growth factor beta production + 20
          regulation of transforming growth factor beta production + 41
          transforming growth factor beta activation + 11
          transforming growth factor beta1 production + 12
          transforming growth factor beta2 production + 8
          transforming growth factor beta3 production + 4
Path 2
Term Annotations click to browse term
  biological_process 11998
    metabolic process 7668
      organic substance metabolic process 7372
        macromolecule metabolic process 6390
          gene expression 3957
            cytokine production 647
              transforming growth factor beta production 43
                negative regulation of transforming growth factor beta production + 14
                positive regulation of transforming growth factor beta production + 20
                regulation of transforming growth factor beta production + 41
                transforming growth factor beta activation + 11
                transforming growth factor beta1 production + 12
                transforming growth factor beta2 production + 8
                transforming growth factor beta3 production + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.