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Term:ER-associated misfolded protein catabolic process
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Accession:GO:0071712 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
Comment:See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
Synonyms:exact_synonym: ER-associated misfolded protein breakdown;   ER-associated misfolded protein catabolism;   ER-associated misfolded protein degradation;   endoplasmic reticulum-associated misfolded protein catabolic process;   endoplasmic reticulum-associated misfolded protein catabolism;   proteasomal protein catabolism of misfolded ER proteins

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ER-associated misfolded protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bag6 BAG cochaperone 6 JBrowse link 20 5,124,512 5,138,084 RGD:1600115
G Derl1 derlin 1 JBrowse link 7 97,737,176 97,759,852 RGD:1624291
G Pomt2 protein-O-mannosyltransferase 2 JBrowse link 6 111,137,329 111,176,991 RGD:13792537
G Rnf185 ring finger protein 185 JBrowse link 14 83,648,400 83,685,273 RGD:13792537
G Rnf5 ring finger protein 5 JBrowse link 20 4,366,244 4,368,690 RGD:1624291
G Sdf2l1 stromal cell-derived factor 2-like 1 JBrowse link 11 88,122,271 88,124,513 RGD:8554667
G Tor1a torsin family 1, member A JBrowse link 3 9,800,322 9,807,318 RGD:1624291
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 JBrowse link 11 86,304,836 86,328,478 RGD:1624291
G Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 JBrowse link 9 42,692,156 42,805,680 RGD:13792537
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19578
    response to stimulus 10490
      response to chemical 6403
        response to organic substance 3825
          response to organonitrogen compound 1445
            ERAD pathway 96
              ER-associated misfolded protein catabolic process 10
Path 2
Term Annotations click to browse term
  biological_process 19578
    metabolic process 11901
      nitrogen compound metabolic process 10025
        organonitrogen compound metabolic process 6969
          organonitrogen compound catabolic process 1282
            protein catabolic process 970
              cellular protein catabolic process 804
                proteolysis involved in cellular protein catabolic process 751
                  proteasomal protein catabolic process 478
                    ERAD pathway 96
                      ER-associated misfolded protein catabolic process 10
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.