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ONTOLOGY REPORT - ANNOTATIONS


Term:adrenergic receptor signaling pathway
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Accession:GO:0071875 term browser browse the term
Definition:A series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands.
Synonyms:exact_synonym: adrenergic receptor signalling pathway;   adrenoceptor signaling pathway


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adrenergic receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1b adrenoceptor alpha 1B IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra1d adrenoceptor alpha 1D IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Adra2a adrenoceptor alpha 2A ISO (PMID:10948191) RGD PMID:10948191 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adra2b adrenoceptor alpha 2B ISO (PMID:17215105) RGD PMID:17215105 NCBI chr 3:119,805,941...119,809,987
Ensembl chr 3:119,805,941...119,809,987
JBrowse link
G Adra2c adrenoceptor alpha 2C ISO (PMID:17215105) RGD PMID:17215105 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010
JBrowse link
G Adrb2 adrenoceptor beta 2 IEA
ISO
GO_REF:0000107
(PMID:19710023)
Ensembl
RGD
PMID:19710023 GO_REF:0000107 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Akap13 A-kinase anchoring protein 13 IMP
IBA
ISO
ISS
PMID:23090968
PMID:21873635
(PMID:21224381), (PMID:23090968)
GO_REF:0000024
RGD
UniProt
PMID:21224381, PMID:23090968, PMID:23090968, PMID:21873635 GO_REF:0000024, RGD:11059571, RGD:13792537 NCBI chr 1:137,089,558...137,315,272
Ensembl chr 1:137,014,272...137,315,272
JBrowse link
G Lmbrd2 LMBR1 domain containing 2 ISO
IBA
(PMID:28388415)
PMID:21873635
RGD PMID:28388415, PMID:21873635 RGD:13792537 NCBI chr 2:58,534,474...58,590,767
Ensembl chr 2:58,534,476...58,590,758
JBrowse link
G Pde4d phosphodiesterase 4D IMP PMID:19801680 BHF-UCL PMID:19801680 RGD:7327160 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264
JBrowse link
G Zdhhc21 zinc finger DHHC-type palmitoyltransferase 21 ISO (MGI:5921050|PMID:26715683) RGD PMID:26715683 MGI:5921050 NCBI chr 5:100,924,621...100,983,412
Ensembl chr 5:100,924,622...100,977,902
JBrowse link
adenylate cyclase-activating adrenergic receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy9 adenylate cyclase 9 ISO (PMID:9628827) RGD PMID:9628827 NCBI chr10:11,392,698...11,515,406
Ensembl chr10:11,392,625...11,512,600
JBrowse link
G Adra1a adrenoceptor alpha 1A IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1b adrenoceptor alpha 1B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra1d adrenoceptor alpha 1D IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Adra2a adrenoceptor alpha 2A ISO
IBA
(PMID:12529373)
PMID:21873635
RGD PMID:12529373, PMID:21873635 RGD:13792537 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adra2b adrenoceptor alpha 2B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:119,805,941...119,809,987
Ensembl chr 3:119,805,941...119,809,987
JBrowse link
G Adra2c adrenoceptor alpha 2C IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010
JBrowse link
G Adrb1 adrenoceptor beta 1 IEA
IBA
ISO
ISS
GO_REF:0000107
PMID:21873635
(PMID:12391161), (PMID:12529373)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:12391161, PMID:12529373, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Drd2 dopamine receptor D2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Drd5 dopamine receptor D5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:77,220,579...77,222,006
Ensembl chr14:77,220,579...77,222,006
JBrowse link
G Gnas GNAS complex locus ISO
ISS
(PMID:12391161)
GO_REF:0000024
RGD
UniProt
PMID:12391161 GO_REF:0000024 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Gpr101 G protein-coupled receptor 101 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:140,296,220...140,303,743
Ensembl chr  X:140,299,770...140,303,686
JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:12391161)
Ensembl
UniProt
RGD
PMID:12391161 GO_REF:0000024, GO_REF:0000107 NCBI chr 2:177,836,191...178,057,378
Ensembl chr 2:177,836,202...178,057,157
JBrowse link
adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chga chromogranin A IDA
IBA
PMID:22459152
PMID:21873635
UniProt
GO_Central
PMID:22459152, PMID:21873635 RGD:6906968, RGD:13792537 NCBI chr 6:126,434,226...126,445,569
Ensembl chr 6:126,434,226...126,445,568
JBrowse link
adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap13 A-kinase anchoring protein 13 ISS
ISO
GO_REF:0000024
(MGI:5770047|PMID:23658642)
UniProt
RGD
PMID:23658642 GO_REF:0000024, MGI:5770047 NCBI chr 1:137,089,558...137,315,272
Ensembl chr 1:137,014,272...137,315,272
JBrowse link
G Pln phospholamban ISO MGI:2158357 (MGI:1351738|PMID:10471356) RGD PMID:10471356 MGI:1351738 NCBI chr20:34,633,157...34,642,904
Ensembl chr20:34,633,157...34,642,904
JBrowse link
adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde4d phosphodiesterase 4D IC PMID:19801680 BHF-UCL PMID:19801680 RGD:7327160 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264
JBrowse link
adenylate cyclase-inhibiting adrenergic receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A ISO (PMID:10948191) RGD PMID:10948191 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrdc3 arrestin domain containing 3 ISO MGI:3877613 (MGI:5302794|PMID:21982743) RGD PMID:21982743 MGI:5302794 NCBI chr 2:8,732,907...8,745,445
Ensembl chr 2:8,732,932...8,743,069
JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 ISO (PMID:17242280) RGD PMID:17242280 NCBI chr13:50,091,644...50,153,808
Ensembl chr13:50,091,430...50,153,823
JBrowse link
G Gnai2 G protein subunit alpha i2 IDA RGD PMID:12631586 RGD:13508593 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Pde4b phosphodiesterase 4B ISO (MGI:5286798|PMID:21670503) RGD PMID:21670503 MGI:5286798 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgs2 regulator of G-protein signaling 2 ISO (MGI:5009116|PMID:21291891) RGD PMID:21291891 MGI:5009116 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
phospholipase C-activating adrenergic receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A ISO (PMID:10948191) RGD PMID:10948191 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsk3a glycogen synthase kinase 3 alpha ISO (MGI:4829580|PMID:20516643) RGD PMID:20516643 MGI:4829580 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
JBrowse link
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nos1 nitric oxide synthase 1 IEA
ISO
GO_REF:0000107
(MGI:3771112|PMID:17242280)
Ensembl
RGD
PMID:17242280 GO_REF:0000107, MGI:3771112 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    signaling 7579
      signal transduction 7010
        G protein-coupled receptor signaling pathway 2509
          adrenergic receptor signaling pathway 29
            activation of MAPK activity by adrenergic receptor signaling pathway 0
            adenylate cyclase-activating adrenergic receptor signaling pathway + 25
            adenylate cyclase-inhibiting adrenergic receptor signaling pathway + 2
            phospholipase C-activating adrenergic receptor signaling pathway 1
            positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological process 13071
        regulation of cellular process 12556
          signal transduction 7010
            G protein-coupled receptor signaling pathway 2509
              adrenergic receptor signaling pathway 29
                activation of MAPK activity by adrenergic receptor signaling pathway 0
                adenylate cyclase-activating adrenergic receptor signaling pathway + 25
                adenylate cyclase-inhibiting adrenergic receptor signaling pathway + 2
                phospholipase C-activating adrenergic receptor signaling pathway 1
                positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.