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ONTOLOGY REPORT - ANNOTATIONS


Term:14-3-3 protein binding
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Accession:GO:0071889 term browser browse the term
Definition:Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.


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14-3-3 protein binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aanat aralkylamine N-acetyltransferase JBrowse link 10 105,568,091 105,572,407 RGD:8553854
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:1624291
RGD:1600115
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5510009
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:10053724
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:1624291
RGD:1600115
G Ddit4 DNA-damage-inducible transcript 4 JBrowse link 20 29,509,283 29,511,382 RGD:1624291
RGD:13792537
RGD:1600115
G Foxk1 forkhead box K1 JBrowse link 12 14,183,436 14,244,634 RGD:1600115
RGD:1624291
G Hdac7 histone deacetylase 7 JBrowse link 7 139,280,396 139,319,108 RGD:1600115
RGD:1624291
G Irs2 insulin receptor substrate 2 JBrowse link 16 83,824,515 83,848,569 RGD:7257698
G Kcnh1 potassium voltage-gated channel subfamily H member 1 JBrowse link 13 110,920,712 111,232,291 RGD:9693692
G Kif13b kinesin family member 13B JBrowse link 15 48,030,837 48,192,932 RGD:1624291
RGD:1600115
G Klhl22 kelch-like family member 22 JBrowse link 11 87,646,489 87,718,808 RGD:1600115
RGD:1624291
G Ksr1 kinase suppressor of ras 1 JBrowse link 10 66,323,704 66,342,469 RGD:1624291
RGD:1600115
G Nek1 NIMA-related kinase 1 JBrowse link 16 32,321,010 32,439,421 RGD:1624291
G Pi4kb phosphatidylinositol 4-kinase beta JBrowse link 2 196,139,724 196,172,055 RGD:1624291
RGD:1600115
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A JBrowse link 7 51,404,971 51,515,382 RGD:1600115
RGD:1624291
G Prkce protein kinase C, epsilon JBrowse link 6 9,483,400 9,973,396 RGD:1624291
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:1642660
G Rbm7 RNA binding motif protein 7 JBrowse link 8 52,823,094 52,828,134 RGD:1624291
G Ripor1 RHO family interacting cell polarization regulator 1 JBrowse link 19 37,555,940 37,584,842 RGD:1600115
RGD:1624291
G Ripor2 RHO family interacting cell polarization regulator 2 JBrowse link 17 42,324,594 42,549,907 RGD:1600115
RGD:1624291
G Rptor regulatory associated protein of MTOR, complex 1 JBrowse link 10 108,750,620 109,058,691 RGD:1624291
RGD:1600115
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:1624291
G Sik1 salt-inducible kinase 1 JBrowse link 20 10,670,747 10,680,279 RGD:1624291
RGD:1600115
G Srpk2 SRSF protein kinase 2 JBrowse link 4 7,994,025 8,187,455 RGD:1624291
G Synpo2 synaptopodin 2 JBrowse link 2 227,255,243 227,411,924 RGD:1624291
RGD:1600115
G Tbc1d22a TBC1 domain family, member 22a JBrowse link 7 127,081,769 127,227,601 RGD:1624291
RGD:1600115
G Tbc1d22b TBC1 domain family, member 22B JBrowse link 20 8,216,097 8,278,344 RGD:1624291
RGD:1600115
G Tmcc3 transmembrane and coiled-coil domain family 3 JBrowse link 7 35,266,953 35,543,770 RGD:1624291
RGD:1600115
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1624291
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta JBrowse link 6 43,463,294 43,493,816 RGD:1642660
G Zfp36 zinc finger protein 36 JBrowse link 1 85,380,088 85,382,565 RGD:1600115
RGD:1624291
G Zfp36l1 zinc finger protein 36, C3H type-like 1 JBrowse link 6 103,308,032 103,313,074 RGD:1600115
RGD:1624291

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  molecular_function 19490
    binding 15890
      protein binding 12627
        14-3-3 protein binding 33
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.