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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of protein serine/threonine kinase activity
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Accession:GO:0071901 term browser browse the term
Definition:Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.


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negative regulation of protein serine/threonine kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 JBrowse link 10 84,780,644 84,789,800 RGD:1624291
RGD:1600115
G Cib1 calcium and integrin binding 1 JBrowse link 1 142,014,962 142,020,461 RGD:1600115
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:1624291
RGD:1600115
G Dtnbp1 dystrobrevin binding protein 1 JBrowse link 17 20,090,136 20,182,332 RGD:1624291
RGD:1600115
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:1600115
RGD:1624291
G Hspb1 heat shock protein family B (small) member 1 JBrowse link 12 23,839,390 23,841,051 RGD:1600115
G Inka1 inka box actin regulator 1 JBrowse link 8 116,763,149 116,764,839 RGD:1600115
G Inka2 inka box actin regulator 2 JBrowse link 2 208,170,652 208,187,088 RGD:1600115
G Lrp5 LDL receptor related protein 5 JBrowse link 1 218,816,833 218,920,147 RGD:1624291
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
G Macroh2a1 macroH2A.1 histone JBrowse link 17 9,282,109 9,344,698 RGD:1624291
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:1624291
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:14397580
G Rptor regulatory associated protein of MTOR, complex 1 JBrowse link 10 108,750,620 109,058,691 RGD:1600115
G Slc8a3 solute carrier family 8 member A3 JBrowse link 6 104,889,500 105,099,408 RGD:1600115
G Tesk1 testis associated actin remodelling kinase 1 JBrowse link 5 58,937,615 58,943,358 RGD:13461749
G Wnk1 WNK lysine deficient protein kinase 1 JBrowse link 4 152,452,211 152,578,469 RGD:1600115
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon JBrowse link 10 63,884,338 63,921,709 RGD:1600115
inactivation of MAPK activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1624291
RGD:1600115
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:1600115
RGD:13792537
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:1624291
RGD:13792537
G Dusp14 dual specificity phosphatase 14 JBrowse link 10 71,363,688 71,383,602 RGD:1600115
G Dusp14l1 dual specificity phosphatase 14-like 1 JBrowse link 2 140,835,793 140,837,188 RGD:1600115
G Dusp16 dual specificity phosphatase 16 JBrowse link 4 168,470,141 168,551,346 RGD:1624291
RGD:13792537
G Dusp18 dual specificity phosphatase 18 JBrowse link 14 84,150,484 84,169,645 RGD:1600115
G Dusp19 dual specificity phosphatase 19 JBrowse link 3 67,849,966 67,862,475 RGD:1624291
G Dusp2 dual specificity phosphatase 2 JBrowse link 3 119,776,925 119,779,110 RGD:13792537
G Dusp21 dual specificity phosphatase 21 JBrowse link X 4,956,699 4,957,555 RGD:1600115
G Dusp3 dual specificity phosphatase 3 JBrowse link 10 89,904,578 89,918,296 RGD:1624291
G Dusp4 dual specificity phosphatase 4 JBrowse link 16 61,080,767 61,090,973 RGD:1600115
RGD:13792537
RGD:1624291
G Dusp5 dual specificity phosphatase 5 JBrowse link 1 274,245,184 274,258,595 RGD:1600115
RGD:13792537
G Dusp6 dual specificity phosphatase 6 JBrowse link 7 41,475,163 41,479,393 RGD:1624291
G Dusp7 dual specificity phosphatase 7 JBrowse link 8 115,069,095 115,076,130 RGD:1600115
G Dusp8 dual specificity phosphatase 8 JBrowse link 1 215,030,429 215,043,111 RGD:1624291
RGD:13792537
G Dusp9 dual specificity phosphatase 9 JBrowse link X 157,168,143 157,172,068 RGD:1624291
G Lax1 lymphocyte transmembrane adaptor 1 JBrowse link 13 50,164,563 50,175,119 RGD:1624291
G Pp2d1 protein phosphatase 2C-like domain containing 1 JBrowse link 14 72,948,241 72,970,335 RGD:1600115
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:1624291
G Spred1 sprouty-related, EVH1 domain containing 1 JBrowse link 3 108,795,337 108,861,650 RGD:1624291
RGD:13792537
G Spred2 sprouty-related, EVH1 domain containing 2 JBrowse link 14 104,268,362 104,290,206 RGD:1624291
RGD:13792537
RGD:1600115
G Spred3 sprouty-related, EVH1 domain containing 3 JBrowse link 1 88,101,213 88,112,719 RGD:1624291
RGD:13792537
negative regulation of cAMP-dependent protein kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pkia cAMP-dependent protein kinase inhibitor alpha JBrowse link 2 96,593,185 96,668,222 RGD:1624291
RGD:13792537
G Pkib cAMP-dependent protein kinase inhibitor beta JBrowse link 20 40,616,868 40,712,598 RGD:1624291
RGD:13792537
RGD:1600115
G Pkig cAMP-dependent protein kinase inhibitor gamma JBrowse link 3 160,047,257 160,115,180 RGD:13792537
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 JBrowse link 4 6,559,153 6,799,888 RGD:1600115
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha JBrowse link 10 97,940,705 97,959,199 RGD:1624291
G Prkar1b protein kinase cAMP-dependent type I regulatory subunit beta JBrowse link 12 17,614,536 17,713,567 RGD:1624291
RGD:1600115
G Prkar2a protein kinase cAMP-dependent type II regulatory subunit alpha JBrowse link 8 117,486,085 117,548,768 RGD:1624291
RGD:1600115
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta JBrowse link 6 51,265,509 51,356,383 RGD:1624291
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
RGD:1600115
negative regulation of cyclin-dependent protein serine/threonine kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apc APC regulator of WNT signaling pathway JBrowse link 18 27,011,710 27,106,323 RGD:1624291
RGD:1600115
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:1624291
G Cdk5rap1 CDK5 regulatory subunit associated protein 1 JBrowse link 3 149,835,953 149,870,429 RGD:1624291
RGD:13792537
RGD:1600115
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:1624291
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:1624291
RGD:13792537
RGD:10045364
G Cdkn1c cyclin-dependent kinase inhibitor 1C JBrowse link 1 216,661,067 216,663,791 RGD:13792537
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:1624291
G Cdkn2b cyclin-dependent kinase inhibitor 2B JBrowse link 5 107,834,353 107,857,428 RGD:1600115
G Cdkn2c cyclin-dependent kinase inhibitor 2C JBrowse link 5 129,347,731 129,352,886 RGD:1624291
G Fbxo7 F-box protein 7 JBrowse link 7 23,815,246 23,843,505 RGD:1624291
G Hexim1 HEXIM P-TEFb complex subunit 1 JBrowse link 10 91,200,874 91,202,986 RGD:1624291
RGD:13792537
RGD:1600115
G Hexim2 HEXIM P-TEFb complex subunit 2 JBrowse link 10 91,212,296 91,222,841 RGD:1624291
RGD:13792537
G Hhex hematopoietically expressed homeobox JBrowse link 1 256,101,994 256,107,581 RGD:1624291
G Inca1 inhibitor of CDK, cyclin A1 interacting protein 1 JBrowse link 10 57,309,722 57,322,140 RGD:1624291
RGD:13792537
G Kat2b lysine acetyltransferase 2B JBrowse link 9 4,440,982 4,492,949 RGD:1624291
G Lats1 large tumor suppressor kinase 1 JBrowse link 1 1,784,078 1,817,310 RGD:1624291
G Lats2 large tumor suppressor kinase 2 JBrowse link 15 37,943,609 37,995,175 RGD:1624291
G Men1 menin 1 JBrowse link 1 221,704,394 221,710,343 RGD:1624291
G Myocd myocardin JBrowse link 10 51,682,053 51,781,458 RGD:1624291
RGD:1600115
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 JBrowse link 1 131,447,671 131,465,749 RGD:1624291
G Plk1 polo-like kinase 1 JBrowse link 1 192,115,990 192,125,969 RGD:1624291
RGD:1600115
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:1624291
G Tfap4 transcription factor AP-4 JBrowse link 10 11,204,616 11,222,975 RGD:1624291
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:1624291
G Wee2 WEE2 oocyte meiosis inhibiting kinase JBrowse link 4 68,604,770 68,631,341 RGD:1624291
negative regulation of JUN kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aida axin interactor, dorsalization associated JBrowse link 13 101,698,096 101,724,928 RGD:1624291
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 JBrowse link 5 57,028,467 57,039,378 RGD:1624291
RGD:1600115
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:1624291
RGD:13792537
G Dusp19 dual specificity phosphatase 19 JBrowse link 3 67,849,966 67,862,475 RGD:1624291
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:1624291
RGD:1600115
G Hipk3 homeodomain interacting protein kinase 3 JBrowse link 3 94,349,778 94,419,185 RGD:1600115
RGD:1624291
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 JBrowse link 3 81,295,023 81,304,181 RGD:1299562
RGD:13673827
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:1624291
G Pdcd4 programmed cell death 4 JBrowse link 1 274,616,625 274,648,204 RGD:1600115
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:1624291
G Serpinb3 serpin family B member 3 JBrowse link 13 27,186,701 27,193,211 RGD:1624291
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1624291
RGD:1600115
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:1624291
G Sfrp5 secreted frizzled-related protein 5 JBrowse link 1 261,442,108 261,446,570 RGD:1624291
G Tp73 tumor protein p73 JBrowse link 5 171,355,876 171,415,354 RGD:1624291
negative regulation of MAP kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:1624291
RGD:1600115
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1600115
RGD:1624291
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1624291
RGD:1600115
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1600115
RGD:1624291
G Bmp7 bone morphogenetic protein 7 JBrowse link 3 170,879,972 170,955,820 RGD:1624291
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1624291
G Cav3 caveolin 3 JBrowse link 4 144,382,945 144,398,919 RGD:1624291
G Cblc Cbl proto-oncogene C JBrowse link 1 80,699,321 80,716,146 RGD:1624291
G Cd300a Cd300a molecule JBrowse link 10 103,437,978 103,451,170 RGD:1624291
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 JBrowse link 10 84,780,644 84,789,800 RGD:1600115
RGD:1624291
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:1600115
RGD:1624291
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:1624291
RGD:1600115
G Dusp7 dual specificity phosphatase 7 JBrowse link 8 115,069,095 115,076,130 RGD:1624291
G Fem1a fem-1 homolog A JBrowse link 9 10,798,934 10,801,140 RGD:1624291
G Gba glucosylceramidase beta JBrowse link 2 188,511,781 188,522,602 RGD:1624291
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:2301767
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:1624291
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link 2 27,480,224 27,500,654 RGD:1624291
G Hyal2 hyaluronidase 2 JBrowse link 8 116,324,062 116,328,978 RGD:1600115
RGD:1624291
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1624291
RGD:1600115
G Inpp5k inositol polyphosphate-5-phosphatase K JBrowse link 10 63,775,639 63,796,879 RGD:1624291
G Inppl1 inositol polyphosphate phosphatase-like 1 JBrowse link 1 166,898,177 166,912,524 RGD:1626126
G Irak3 interleukin-1 receptor-associated kinase 3 JBrowse link 7 64,922,830 64,982,224 RGD:1624291
RGD:13792537
G Kng2 kininogen 2 JBrowse link 11 81,509,185 81,516,759 RGD:1600541
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:1624291
RGD:1600115
G Mapk7 mitogen-activated protein kinase 7 JBrowse link 10 47,768,592 47,775,130 RGD:1624291
G Nf1 neurofibromin 1 JBrowse link 10 66,732,460 66,928,706 RGD:1600115
RGD:1624291
G Nup62 nucleoporin 62 JBrowse link 1 100,811,140 100,827,119 RGD:1624291
G Paqr3 progestin and adipoQ receptor family member 3 JBrowse link 14 14,107,513 14,129,780 RGD:1624291
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:1624291
RGD:1600115
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:1624291
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 JBrowse link 1 103,197,918 103,258,309 RGD:10044039
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:1600115
RGD:1624291
G Ptprj protein tyrosine phosphatase, receptor type, J JBrowse link 3 79,233,519 79,390,956 RGD:1624291
RGD:13792537
G Rgs14 regulator of G-protein signaling 14 JBrowse link 17 9,777,925 9,792,007 RGD:1624291
RGD:1600115
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:1624291
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:1624291
RGD:1600115
G Smpd1 sphingomyelin phosphodiesterase 1 JBrowse link 1 170,383,682 170,387,525 RGD:1624291
G Sorl1 sortilin related receptor 1 JBrowse link 8 46,228,077 46,287,171 RGD:1624291
G Spry1 sprouty RTK signaling antagonist 1 JBrowse link 2 124,400,689 124,405,331 RGD:1624291
RGD:13792537
G Spry2 sprouty RTK signaling antagonist 2 JBrowse link 15 90,172,769 90,177,823 RGD:1624291
RGD:13792537
G Spry3 sprouty RTK signaling antagonist 3 JBrowse link 12 18,930,087 18,940,622 RGD:13792537
G Spry4 sprouty RTK signaling antagonist 4 JBrowse link 18 32,593,370 32,609,890 RGD:1624291
RGD:13792537
G Stk38 serine/threonine kinase 38 JBrowse link 20 6,224,300 6,257,613 RGD:1624291
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1580517
G Uchl1 ubiquitin C-terminal hydrolase L1 JBrowse link 14 43,133,224 43,143,942 RGD:1624291
negative regulation of Rho-dependent protein serine/threonine kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chordc1 cysteine and histidine rich domain containing 1 JBrowse link 8 17,421,552 17,445,513 RGD:1624291
G Heg1 heart development protein with EGF-like domains 1 JBrowse link 11 70,234,248 70,322,966 RGD:1624291
G Rasip1 Ras interacting protein 1 JBrowse link 1 101,609,209 101,621,648 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19332
    metabolic process 11554
      negative regulation of metabolic process 3059
        negative regulation of cellular metabolic process 2677
          negative regulation of cellular protein metabolic process 1113
            negative regulation of protein modification process 626
              negative regulation of protein phosphorylation 430
                negative regulation of protein kinase activity 223
                  negative regulation of protein serine/threonine kinase activity 132
                    inactivation of MAPKKK activity 0
                    negative regulation of MAP kinase activity + 78
                    negative regulation of Rho-dependent protein serine/threonine kinase activity 3
                    negative regulation of cAMP-dependent protein kinase activity 9
                    negative regulation of cyclin-dependent protein serine/threonine kinase activity + 25
                    negative regulation of myosin light chain kinase activity 0
Path 2
Term Annotations click to browse term
  biological_process 19332
    biological regulation 13335
      regulation of biological process 12650
        regulation of metabolic process 6536
          regulation of cellular metabolic process 6024
            regulation of phosphorus metabolic process 1854
              regulation of phosphate metabolic process 1853
                regulation of phosphorylation 1656
                  regulation of kinase activity 868
                    regulation of protein kinase activity 758
                      negative regulation of protein kinase activity 223
                        negative regulation of protein serine/threonine kinase activity 132
                          inactivation of MAPKKK activity 0
                          negative regulation of MAP kinase activity + 78
                          negative regulation of Rho-dependent protein serine/threonine kinase activity 3
                          negative regulation of cAMP-dependent protein kinase activity 9
                          negative regulation of cyclin-dependent protein serine/threonine kinase activity + 25
                          negative regulation of myosin light chain kinase activity 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.