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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of protein serine/threonine kinase activity
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Accession:GO:0071901 term browser browse the term
Definition:Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.


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negative regulation of protein serine/threonine kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link NW_004955513 652,048 799,182 RGD:9068941
G Akt1 AKT serine/threonine kinase 1 JBrowse link NW_004955538 3,208,711 3,224,386 RGD:9068941
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 JBrowse link NW_004955451 13,160,811 13,170,012 RGD:9068941
G Cib1 calcium and integrin binding 1 JBrowse link NW_004955416 15,102,632 15,106,372 RGD:9068941
G Dab2ip DAB2 interacting protein JBrowse link NW_004955419 6,229,437 6,416,619 RGD:9068941
G Dtnbp1 dystrobrevin binding protein 1 JBrowse link NW_004955590 276,143 382,812 RGD:9068941
G Gadd45a growth arrest and DNA damage inducible alpha JBrowse link NW_004955423 23,656,516 23,658,367 RGD:9068941
G Hspb1 heat shock protein family B (small) member 1 JBrowse link NW_004955844 8,094 9,565 RGD:9068941
G Inka1 inka box actin regulator 1 JBrowse link NW_004955532 1,695,956 1,697,521 RGD:9068941
G Inka2 inka box actin regulator 2 JBrowse link NW_004955435 15,179,883 15,195,457 RGD:9068941
G LOC102008188 core histone macro-H2A.1 JBrowse link NW_004955408 30,497,531 30,550,095 RGD:9068941
G Lrp5 LDL receptor related protein 5 JBrowse link NW_004955422 17,394,371 17,475,244 RGD:9068941
G Lrp6 LDL receptor related protein 6 JBrowse link NW_004955413 9,080,901 9,237,644 RGD:9068941
G Rb1 RB transcriptional corepressor 1 JBrowse link NW_004955431 1,960,765 2,124,576 RGD:9068941
G Rptor regulatory associated protein of MTOR complex 1 JBrowse link NW_004955506 2,009,422 2,401,775 RGD:9068941
G Sfn stratifin JBrowse link NW_004955452 6,217,519 6,218,481 RGD:9068941
G Slc8a1 solute carrier family 8 member A1 JBrowse link NW_004955441 7,653,107 8,037,784 RGD:9068941
G Slc8a3 solute carrier family 8 member A3 JBrowse link NW_004955466 220,346 359,627 RGD:9068941
G Tesk1 testis associated actin remodelling kinase 1 JBrowse link NW_004955472 670,847 676,060 RGD:9068941
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma JBrowse link NW_004955456 14,939,130 14,970,248 RGD:9068941
inactivation of MAPK activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav1 caveolin 1 JBrowse link NW_004955432 22,258,262 22,292,403 RGD:9068941
G Dusp1 dual specificity phosphatase 1 JBrowse link NW_004955408 25,481,294 25,484,381 RGD:9068941
G Dusp10 dual specificity phosphatase 10 JBrowse link NW_004955520 2,338,548 2,371,591 RGD:9068941
G Dusp14 dual specificity phosphatase 14 JBrowse link NW_004955451 515,889 537,762 RGD:9068941
G Dusp16 dual specificity phosphatase 16 JBrowse link NW_004955413 9,404,259 9,481,061 RGD:9068941
G Dusp18 dual specificity phosphatase 18 JBrowse link NW_004955455 4,899,090 4,906,785 RGD:9068941
G Dusp2 dual specificity phosphatase 2 JBrowse link NW_004955470 3,735,224 3,737,667 RGD:9068941
G Dusp21 dual specificity phosphatase 21 JBrowse link NW_004955516 3,369,548 3,370,403 RGD:9068941
G Dusp3 dual specificity phosphatase 3 JBrowse link NW_004955451 17,064,739 17,069,964 RGD:9068941
G Dusp4 dual specificity phosphatase 4 JBrowse link NW_004955463 5,778,945 5,794,282 RGD:9068941
G Dusp5 dual specificity phosphatase 5 JBrowse link NW_004955485 914,250 927,640 RGD:9068941
G Dusp6 dual specificity phosphatase 6 JBrowse link NW_004955405 26,662,018 26,666,314 RGD:9068941
G Dusp7 dual specificity phosphatase 7 JBrowse link NW_004955532 3,685,137 3,691,933 RGD:9068941
G Dusp8 dual specificity phosphatase 8 JBrowse link NW_004955476 10,816,647 10,826,787 RGD:9068941
G Dusp9 dual specificity phosphatase 9 JBrowse link NW_004955580 388,277 392,269 RGD:9068941
G Gps1 G protein pathway suppressor 1 JBrowse link NW_004955506 1,105,157 1,110,129 RGD:9068941
G Gps2 G protein pathway suppressor 2 JBrowse link NW_004955467 9,600,829 9,604,148 RGD:9068941
G Lax1 lymphocyte transmembrane adaptor 1 JBrowse link NW_004955406 39,656,549 39,667,448 RGD:9068941
G Pp2d1 protein phosphatase 2C like domain containing 1 JBrowse link NW_004955430 12,039,391 12,070,440 RGD:9068941
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link NW_004955408 5,435,117 5,460,361 RGD:9068941
G Ppp2r1a protein phosphatase 2 scaffold subunit Aalpha JBrowse link NW_004955558 381,794 410,485 RGD:9068941
G Rgs3 regulator of G protein signaling 3 JBrowse link NW_004955419 13,918,274 14,042,090 RGD:9068941
G Rgs4 regulator of G protein signaling 4 JBrowse link NW_004955462 13,340,812 13,347,598 RGD:9068941
G Spred1 sprouty related EVH1 domain containing 1 JBrowse link NW_004955416 5,288,779 5,376,861 RGD:9068941
G Spred2 sprouty related EVH1 domain containing 2 JBrowse link NW_004955424 19,133,568 19,250,118 RGD:9068941
G Spred3 sprouty related EVH1 domain containing 3 JBrowse link NW_004955468 1,030,964 1,039,495 RGD:9068941
inactivation of MAPK activity involved in osmosensory signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mbip MAP3K12 binding inhibitory protein 1 JBrowse link NW_004955409 24,821,884 24,848,125 RGD:9068941
negative regulation of cAMP-dependent protein kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pkia cAMP-dependent protein kinase inhibitor alpha JBrowse link NW_004955444 2,498,785 2,532,881 RGD:9068941
G Pkib cAMP-dependent protein kinase inhibitor beta JBrowse link NW_004955436 4,433,065 4,600,967 RGD:9068941
G Pkig cAMP-dependent protein kinase inhibitor gamma JBrowse link NW_004955445 12,717,962 12,818,734 RGD:9068941
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 JBrowse link NW_004955491 5,852,534 6,048,820 RGD:9068941
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha JBrowse link NW_004955478 4,241,283 4,262,119 RGD:9068941
G Prkar1b protein kinase cAMP-dependent type I regulatory subunit beta JBrowse link NW_004955460 8,357,890 8,479,875 RGD:9068941
G Prkar2a protein kinase cAMP-dependent type II regulatory subunit alpha JBrowse link NW_004955532 827,112 896,487 RGD:9068941
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta JBrowse link NW_004955410 11,529,530 11,620,085 RGD:9068941
G Sirt1 sirtuin 1 JBrowse link NW_004955425 20,280,725 20,307,663 RGD:9068941
negative regulation of cyclin-dependent protein serine/threonine kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apc APC regulator of WNT signaling pathway JBrowse link NW_004955418 2,567,804 2,675,062 RGD:9068941
G Casp3 caspase 3 JBrowse link NW_004955403 24,315,712 24,326,271 RGD:9068941
G Cdk5rap1 CDK5 regulatory subunit associated protein 1 JBrowse link NW_004955422 27,878,048 27,907,157 RGD:9068941
G Cdkn1a cyclin dependent kinase inhibitor 1A JBrowse link NW_004955437 6,254,638 6,261,278 RGD:9068941
G Cdkn1b cyclin dependent kinase inhibitor 1B JBrowse link NW_004955413 9,615,542 9,620,542 RGD:9068941
G Cdkn1c cyclin dependent kinase inhibitor 1C JBrowse link NW_004955422 14,576,971 14,578,868 RGD:9068941
G Cdkn2b cyclin dependent kinase inhibitor 2B JBrowse link NW_004955472 12,275,613 12,280,141 RGD:9068941
G Cdkn2c cyclin dependent kinase inhibitor 2C JBrowse link NW_004955464 8,022,596 8,028,241 RGD:9068941
G Cdkn2d cyclin dependent kinase inhibitor 2D JBrowse link NW_004955495 1,755,280 1,759,125 RGD:9068941
G Cebpa CCAAT enhancer binding protein alpha JBrowse link NW_004955468 3,046,544 3,049,217 RGD:9068941
G Fbxo7 F-box protein 7 JBrowse link NW_004955405 41,429,421 41,449,670 RGD:9068941
G Hhex hematopoietically expressed homeobox JBrowse link NW_004955425 737,506 742,775 RGD:9068941
G Inca1 inhibitor of CDK, cyclin A1 interacting protein 1 JBrowse link NW_004955467 10,391,957 10,397,212 RGD:9068941
G Ipo5 importin 5 JBrowse link NW_004955404 12,416,755 12,480,281 RGD:9068941
G Ipo7 importin 7 JBrowse link NW_004955414 25,131,703 25,195,892 RGD:9068941
G Kat2b lysine acetyltransferase 2B JBrowse link NW_004955430 12,109,493 12,196,102 RGD:9068941
G Lats1 large tumor suppressor kinase 1 JBrowse link NW_004955439 11,559,655 11,611,287 RGD:9068941
G Lats2 large tumor suppressor kinase 2 JBrowse link NW_004955497 1,711,882 1,768,177 RGD:9068941
G Men1 menin 1 JBrowse link NW_004955422 20,356,491 20,363,374 RGD:9068941
G Myocd myocardin JBrowse link NW_004955467 4,653,065 4,743,438 RGD:9068941
G Nr2f2 nuclear receptor subfamily 2 group F member 2 JBrowse link NW_004955416 24,148,052 24,154,406 RGD:9068941
G Plk1 polo like kinase 1 JBrowse link NW_004955493 2,206,353 2,217,231 RGD:9068941
G Pten phosphatase and tensin homolog JBrowse link NW_004955425 5,007,811 5,091,829 RGD:9068941
G Tfap4 transcription factor AP-4 JBrowse link NW_004955442 13,160,467 13,174,288 RGD:9068941
G Tnfaip3 TNF alpha induced protein 3 JBrowse link NW_004955436 21,566,591 21,581,551 RGD:9068941
G Wee2 WEE2 oocyte meiosis inhibiting kinase JBrowse link NW_004955494 1,836,909 1,869,384 RGD:9068941
negative regulation of JUN kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aida axin interactor, dorsalization associated JBrowse link NW_004955520 1,819,617 1,851,273 RGD:9068941
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 JBrowse link NW_004955472 2,604,002 2,618,033 RGD:9068941
G Dusp10 dual specificity phosphatase 10 JBrowse link NW_004955520 2,338,548 2,371,591 RGD:9068941
G Dusp19 dual specificity phosphatase 19 JBrowse link NW_004955403 14,421,057 14,439,829 RGD:9068941
G Gstp1 glutathione S-transferase pi 1 JBrowse link NW_004955422 17,914,228 17,916,918 RGD:9068941
G Hipk3 homeodomain interacting protein kinase 3 JBrowse link NW_004955422 12,841,781 12,928,194 RGD:9068941
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 JBrowse link NW_004955422 2,064,010 2,081,681 RGD:9068941
G Nppa natriuretic peptide A JBrowse link NW_004955486 2,061,196 2,062,805 RGD:9068941
G Pdcd4 programmed cell death 4 JBrowse link NW_004955485 530,642 553,508 RGD:9068941
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 JBrowse link NW_004955435 17,082,762 17,139,067 RGD:9068941
G Sfrp1 secreted frizzled related protein 1 JBrowse link NW_004955536 1,663,721 1,702,678 RGD:9068941
G Sfrp2 secreted frizzled related protein 2 JBrowse link NW_004955471 8,103,937 8,112,596 RGD:9068941
negative regulation of MAP kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link NW_004955420 20,911,181 20,922,992 RGD:9068941
G Agt angiotensinogen JBrowse link NW_004955492 7,863,662 7,874,863 RGD:9068941
G Apoe apolipoprotein E JBrowse link NW_004955555 1,998,170 2,002,003 RGD:9068941
G Bmp4 bone morphogenetic protein 4 JBrowse link NW_004955409 9,432,835 9,439,680 RGD:9068941
G Bmp7 bone morphogenetic protein 7 JBrowse link NW_004955445 2,154,057 2,235,594 RGD:9068941
G Cav3 caveolin 3 JBrowse link NW_004955561 326,008 335,911 RGD:9068941
G Cblc Cbl proto-oncogene C JBrowse link NW_004955555 1,921,896 1,941,247 RGD:9068941
G Cd300a CD300a molecule JBrowse link NW_004955553 1,335,854 1,356,001 RGD:9068941
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 JBrowse link NW_004955451 13,160,811 13,170,012 RGD:9068941
G Dab2ip DAB2 interacting protein JBrowse link NW_004955419 6,229,437 6,416,619 RGD:9068941
G Dusp1 dual specificity phosphatase 1 JBrowse link NW_004955408 25,481,294 25,484,381 RGD:9068941
G Dusp6 dual specificity phosphatase 6 JBrowse link NW_004955405 26,662,018 26,666,314 RGD:9068941
G Dusp7 dual specificity phosphatase 7 JBrowse link NW_004955532 3,685,137 3,691,933 RGD:9068941
G Dusp9 dual specificity phosphatase 9 JBrowse link NW_004955580 388,277 392,269 RGD:9068941
G Gba glucosylceramidase beta JBrowse link NW_004955545 1,682,097 1,689,373 RGD:9068941
G Gstp1 glutathione S-transferase pi 1 JBrowse link NW_004955422 17,914,228 17,916,918 RGD:9068941
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link NW_004955425 25,362,165 25,380,611 RGD:9068941
G Hyal2 hyaluronidase 2 JBrowse link NW_004955532 2,120,781 2,125,083 RGD:9068941
G Il1b interleukin 1 beta JBrowse link NW_004955470 1,486,936 1,491,888 RGD:9068941
G Inpp5k inositol polyphosphate-5-phosphatase K JBrowse link NW_004955481 1,651,422 1,674,402 RGD:9068941
G Irak3 interleukin 1 receptor associated kinase 3 JBrowse link NW_004955458 12,839,995 12,880,285 RGD:9068941
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link NW_004955454 15,025,967 15,111,142 RGD:9068941
G Nf1 neurofibromin 1 JBrowse link NW_004955481 6,145,855 6,404,179 RGD:9068941
G Nup62 nucleoporin 62 JBrowse link NW_004955559 1,012,919 1,033,465 RGD:9068941
G Paqr3 progestin and adipoQ receptor family member 3 JBrowse link NW_004955433 3,323,426 3,350,358 RGD:9068941
G Prkcd protein kinase C delta JBrowse link NW_004955430 3,125,066 3,151,857 RGD:9068941
G Ptpn1 protein tyrosine phosphatase non-receptor type 1 JBrowse link NW_004955445 7,754,313 7,819,229 RGD:9068941
G Ptpn6 protein tyrosine phosphatase non-receptor type 6 JBrowse link NW_004955413 4,525,954 4,547,177 RGD:9068941
G Ptprj protein tyrosine phosphatase receptor type J JBrowse link NW_004955422 396,266 438,792 RGD:9068941
G Rgs14 regulator of G protein signaling 14 JBrowse link NW_004955408 29,602,654 29,616,793 RGD:9068941
G Rgs2 regulator of G protein signaling 2 JBrowse link NW_004955406 30,261,757 30,265,389 RGD:9068941
G Sh2b3 SH2B adaptor protein 3 JBrowse link NW_004955482 8,079,905 8,100,791 RGD:9068941
G Smpd1 sphingomyelin phosphodiesterase 1 JBrowse link NW_004955414 22,117,929 22,121,744 RGD:9068941
G Sorl1 sortilin related receptor 1 JBrowse link NW_004955412 22,421,984 22,576,179 RGD:9068941
G Spry1 sprouty RTK signaling antagonist 1 JBrowse link NW_004955428 17,451,703 17,455,695 RGD:9068941
G Spry2 sprouty RTK signaling antagonist 2 JBrowse link NW_004955404 27,349,286 27,353,706 RGD:9068941
G Spry3 sprouty RTK signaling antagonist 3 JBrowse link NW_004955594 151,117 158,627 RGD:9068941
G Spry4 sprouty RTK signaling antagonist 4 JBrowse link NW_004955415 11,489,439 11,504,247 RGD:9068941
G Stk38 serine/threonine kinase 38 JBrowse link NW_004955437 4,142,285 4,186,376 RGD:9068941
G Uchl1 ubiquitin C-terminal hydrolase L1 JBrowse link NW_004955443 6,367,519 6,379,638 RGD:9068941
negative regulation of Rho-dependent protein serine/threonine kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chordc1 cysteine and histidine rich domain containing 1 JBrowse link NW_004955414 3,699,652 3,717,200 RGD:9068941
G Heg1 heart development protein with EGF like domains 1 JBrowse link NW_004955427 24,035,193 24,115,483 RGD:9068941
G Rasip1 Ras interacting protein 1 JBrowse link NW_004955559 1,830,574 1,844,107 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14616
    metabolic process 10124
      negative regulation of metabolic process 2954
        negative regulation of cellular metabolic process 2401
          negative regulation of cellular protein metabolic process 953
            negative regulation of protein modification process 578
              negative regulation of protein phosphorylation 394
                negative regulation of protein kinase activity 224
                  negative regulation of protein serine/threonine kinase activity 129
                    inactivation of MAPKKK activity 0
                    negative regulation of MAP kinase activity + 73
                    negative regulation of Rho-dependent protein serine/threonine kinase activity 3
                    negative regulation of cAMP-dependent protein kinase activity 9
                    negative regulation of cyclin-dependent protein serine/threonine kinase activity + 26
                    negative regulation of myosin light chain kinase activity 0
Path 2
Term Annotations click to browse term
  biological_process 14616
    biological regulation 10479
      regulation of biological process 9907
        regulation of metabolic process 6099
          regulation of cellular metabolic process 5476
            regulation of phosphorus metabolic process 1710
              regulation of phosphate metabolic process 1709
                regulation of phosphorylation 1523
                  regulation of kinase activity 873
                    regulation of protein kinase activity 770
                      negative regulation of protein kinase activity 224
                        negative regulation of protein serine/threonine kinase activity 129
                          inactivation of MAPKKK activity 0
                          negative regulation of MAP kinase activity + 73
                          negative regulation of Rho-dependent protein serine/threonine kinase activity 3
                          negative regulation of cAMP-dependent protein kinase activity 9
                          negative regulation of cyclin-dependent protein serine/threonine kinase activity + 26
                          negative regulation of myosin light chain kinase activity 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.