ONTOLOGY REPORT - ANNOTATIONS


Term:multivesicular body sorting pathway
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Accession:GO:0071985 term browser browse the term
Definition:A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded.


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multivesicular body sorting pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chmp5 charged multivesicular body protein 5 JBrowse link 5 57,267,312 57,284,455 RGD:1624291
RGD:1600115
G Exph5 exophilin 5 JBrowse link 8 57,885,932 57,962,574 RGD:1624291
RGD:1600115
RGD:13792537
G Mitd1 microtubule interacting and trafficking domain containing 1 JBrowse link 9 44,472,364 44,483,723 RGD:1624291
G Rab27a RAB27A, member RAS oncogene family JBrowse link 8 79,722,334 79,776,228 RGD:1624291
RGD:1600115
G Rab27b RAB27B, member RAS oncogene family JBrowse link 18 68,486,006 68,644,595 RGD:1624291
RGD:1600115
G Sytl4 synaptotagmin-like 4 JBrowse link X 104,763,961 104,814,152 RGD:1600115
RGD:1624291
G Vta1 vesicle trafficking 1 JBrowse link 1 8,830,405 8,878,191 RGD:1624291
RGD:1600115
endosome to lysosome transport via multivesicular body sorting pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lyst lysosomal trafficking regulator JBrowse link 17 90,323,055 90,522,091 RGD:1624291
G Ubxn6 UBX domain protein 6 JBrowse link 9 10,995,516 11,000,643 RGD:1624291
RGD:1600115
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:1624291
RGD:1600115
G Vps4b vacuolar protein sorting 4 homolog B JBrowse link 13 26,825,261 26,850,460 RGD:1624291
RGD:1600115
endosome transport via multivesicular body sorting pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chmp1a charged multivesicular body protein 1A JBrowse link 19 56,001,724 56,010,004 RGD:13792537
G Chmp2a charged multivesicular body protein 2A JBrowse link 1 65,540,808 65,543,708 RGD:13792537
G Chmp2b charged multivesicular body protein 2B JBrowse link 11 2,666,405 2,692,213 RGD:13792537
G Chmp3 charged multivesicular body protein 3 JBrowse link 4 99,449,213 99,496,156 RGD:13792537
G Laptm4b lysosomal protein transmembrane 4 beta JBrowse link 7 72,924,911 72,968,099 RGD:1624291
RGD:1600115
G RGD1566265 similar to RIKEN cDNA 2610002M06 JBrowse link X 78,870,964 78,911,601 RGD:13792537
G Rilp Rab interacting lysosomal protein JBrowse link 10 63,658,451 63,662,428 RGD:1624291
RGD:1600115
G Sort1 sortilin 1 JBrowse link 2 211,078,092 211,156,312 RGD:1624291
RGD:1600115
G Vps36 vacuolar protein sorting 36 homolog JBrowse link 16 74,719,642 74,743,921 RGD:1600115
G Vps37a VPS37A subunit of ESCRT-I JBrowse link 16 54,860,811 54,899,410 RGD:1600115
G Vps37b VPS37B subunit of ESCRT-I JBrowse link 12 37,984,790 38,023,369 RGD:1600115
G Vps37c VPS37C subunit of ESCRT-I JBrowse link 1 226,742,267 226,774,109 RGD:1600115
G Vps37d VPS37D subunit of ESCRT-I JBrowse link 12 24,651,342 24,656,793 RGD:1600115
late endosome to vacuole transport via multivesicular body sorting pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Leprot leptin receptor overlapping transcript JBrowse link 5 120,498,910 120,511,011 RGD:13792537
G Leprotl1 leptin receptor overlapping transcript-like 1 JBrowse link 16 61,758,941 61,769,655 RGD:13792537
G Tmem50a transmembrane protein 50A JBrowse link 5 153,233,965 153,252,006 RGD:13792537
G Tmem50b transmembrane protein 50B JBrowse link 11 31,719,441 31,752,276 RGD:13792537
multivesicular body-lysosome fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chmp3 charged multivesicular body protein 3 JBrowse link 4 99,449,213 99,496,156 RGD:1624291
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Snf8 SNF8 subunit of ESCRT-II JBrowse link 10 83,856,331 83,868,621 RGD:13792537
G Vps25 vacuolar protein sorting 25 homolog JBrowse link 10 89,174,684 89,180,165 RGD:13792537
G Vps28 VPS28 subunit of ESCRT-I JBrowse link 7 117,684,339 117,688,187 RGD:1600115
RGD:13792537
G Vps36 vacuolar protein sorting 36 homolog JBrowse link 16 74,719,642 74,743,921 RGD:13792537
regulation of multivesicular body size involved in endosome transport term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Snf8 SNF8 subunit of ESCRT-II JBrowse link 10 83,856,331 83,868,621 RGD:1624291
RGD:1600115

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Term Annotations click to browse term
  biological_process 17895
    localization 5951
      establishment of localization 4561
        transport 4425
          vesicle-mediated transport 1417
            multivesicular body sorting pathway 31
              endosome transport via multivesicular body sorting pathway + 24
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.