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ONTOLOGY REPORT - ANNOTATIONS


Term:intrinsic apoptotic signaling pathway by p53 class mediator
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Accession:GO:0072332 term browser browse the term
Definition:A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.
Synonyms:exact_synonym: intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator
 related_synonym: signal transduction by p53 class mediator resulting in induction of apoptosis


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intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1624291
RGD:1600115
G Bok BCL2 family apoptosis regulator BOK JBrowse link 9 100,829,593 100,840,498 RGD:1624291
G Ddx5 DEAD-box helicase 5 JBrowse link 10 94,979,759 94,988,461 RGD:1624291
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:1624291
G E2f2 E2F transcription factor 2 JBrowse link 5 154,516,611 154,540,228 RGD:1624291
G Eda2r ectodysplasin A2 receptor JBrowse link X 66,560,200 66,602,509 RGD:1624291
G Fhit fragile histidine triad diadenosine triphosphatase JBrowse link 15 15,697,292 16,862,873 RGD:1624291
RGD:13792537
RGD:1600115
G Hint1 histidine triad nucleotide binding protein 1 JBrowse link 10 40,208,236 40,211,981 RGD:1624291
RGD:1600115
G Jmy junction mediating and regulatory protein, p53 cofactor JBrowse link 2 23,026,506 23,097,702 RGD:1624291
RGD:13792537
G Mybbp1a MYB binding protein 1a JBrowse link 10 59,000,400 59,010,794 RGD:1624291
G Pdk2 pyruvate dehydrogenase kinase 2 JBrowse link 10 82,838,270 82,852,758 RGD:1600115
RGD:1624291
G Perp PERP, TP53 apoptosis effector JBrowse link 1 14,224,392 14,236,838 RGD:1624291
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:1624291
G Pml PML nuclear body scaffold JBrowse link 8 63,002,515 63,034,310 RGD:1624291
G Pou4f1 POU class 4 homeobox 1 JBrowse link 15 88,618,255 88,622,712 RGD:1624291
RGD:1600115
G Pou4f2 POU class 4 homeobox 2 JBrowse link 19 33,160,180 33,163,821 RGD:1624291
RGD:1600115
G Ppp1r13b protein phosphatase 1, regulatory subunit 13B JBrowse link 6 136,397,658 136,469,757 RGD:1624291
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:1624291
G Rrp8 ribosomal RNA processing 8 JBrowse link 1 170,574,670 170,578,693 RGD:1624291
G Shisa5 shisa family member 5 JBrowse link 8 117,780,992 117,795,923 RGD:1624291
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:1600115
RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Tp53bp2 tumor protein p53 binding protein, 2 JBrowse link 13 100,817,206 100,873,837 RGD:1624291
G Wwox WW domain-containing oxidoreductase JBrowse link 19 46,761,353 47,695,247 RGD:1624291
G Zfp385b zinc finger protein 385B JBrowse link 3 64,269,817 64,556,084 RGD:1624291
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aen apoptosis enhancing nuclease JBrowse link 1 140,584,328 140,593,749 RGD:1624291
RGD:13792537
RGD:1600115
G Atad5 ATPase family, AAA domain containing 5 JBrowse link 10 67,427,042 67,475,825 RGD:1624291
G Bag6 BAG cochaperone 6 JBrowse link 20 5,124,512 5,138,084 RGD:1624291
RGD:1600115
G Bbc3 Bcl-2 binding component 3 JBrowse link 1 78,261,491 78,267,802 RGD:1624291
G Bcl3 BCL3, transcription coactivator JBrowse link 1 80,730,758 80,745,273 RGD:1624291
G Brca2 BRCA2, DNA repair associated JBrowse link 12 503,660 544,754 RGD:1600115
RGD:1624291
G Cdip1 cell death-inducing p53 target 1 JBrowse link 10 10,966,819 10,989,937 RGD:1624291
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:1624291
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:1624291
G Ddit4 DNA-damage-inducible transcript 4 JBrowse link 20 29,509,283 29,511,382 RGD:1600115
RGD:1624291
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 JBrowse link 7 61,785,423 61,816,775 RGD:1624291
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:1624291
G Hipk1 homeodomain interacting protein kinase 1 JBrowse link 2 206,224,015 206,274,910 RGD:1624291
RGD:13792537
RGD:1600115
G Hipk2 homeodomain interacting protein kinase 2 JBrowse link 4 66,438,390 66,625,183 RGD:1624291
RGD:13792537
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:1624291
RGD:13792537
RGD:1600115
G Nupr1 nuclear protein 1, transcriptional regulator JBrowse link 1 194,767,484 194,769,519 RGD:1624291
G Phlda3 pleckstrin homology-like domain, family A, member 3 JBrowse link 13 52,588,917 52,592,002 RGD:1624291
RGD:13792537
RGD:1600115
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:1624291
G Pml PML nuclear body scaffold JBrowse link 8 63,002,515 63,034,310 RGD:1624291
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma JBrowse link 6 134,804,128 134,941,912 RGD:1624291
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:1624291
G Rps27l ribosomal protein S27-like JBrowse link 8 72,741,155 72,746,090 RGD:1624291
G Shisa5 shisa family member 5 JBrowse link 8 117,780,992 117,795,923 RGD:1624291
RGD:1600115
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
RGD:1600115
G Snw1 SNW domain containing 1 JBrowse link 6 111,483,698 111,507,782 RGD:1624291
G Tmem109 transmembrane protein 109 JBrowse link 1 226,925,114 226,935,710 RGD:1624291
RGD:13792537
G Topors TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase JBrowse link 5 56,554,956 56,566,503 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Tp63 tumor protein p63 JBrowse link 11 78,234,853 78,456,559 RGD:1624291
G Tp73 tumor protein p73 JBrowse link 5 171,355,876 171,415,354 RGD:1624291
G Usp28 ubiquitin specific peptidase 28 JBrowse link 8 53,295,188 53,355,572 RGD:1600115
RGD:1624291
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Armc10 armadillo repeat containing 10 JBrowse link 4 10,004,846 10,020,017 RGD:1624291
G Cep63 centrosomal protein 63 JBrowse link 8 111,063,988 111,116,014 RGD:1624291
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:1624291
G Mdm4 MDM4 regulator of p53 JBrowse link 13 49,786,776 49,828,780 RGD:1624291
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
G Pttg1ip PTTG1 interacting protein JBrowse link 20 11,746,369 11,764,097 RGD:1624291
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B JBrowse link 7 76,750,045 76,780,817 RGD:1624291
G Rrn3 RRN3 homolog, RNA polymerase I transcription factor JBrowse link 10 3,170,387 3,214,648 RGD:1624291
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 JBrowse link 2 250,709,812 250,744,216 RGD:1624291
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atad5 ATPase family, AAA domain containing 5 JBrowse link 10 67,427,042 67,475,825 RGD:1624291
G Bcl2l12 BCL2 like 12 JBrowse link 1 100,984,550 100,993,269 RGD:1624291
G Cd44 CD44 molecule (Indian blood group) JBrowse link 3 92,695,083 92,783,820 RGD:1624291
RGD:1600115
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
RGD:13792537
RGD:1600115
G Ell3 elongation factor for RNA polymerase II 3 JBrowse link 3 113,400,395 113,405,869 RGD:1624291
G Kdm1a lysine demethylase 1A JBrowse link 5 154,909,003 154,965,171 RGD:1624291
G Marchf7 membrane associated ring-CH-type finger 7 JBrowse link 3 46,284,961 46,325,230 RGD:1624291
RGD:1600115
G Mif macrophage migration inhibitory factor JBrowse link 20 13,715,219 13,732,980 RGD:1624291
G Muc1 mucin 1, cell surface associated JBrowse link 2 188,543,137 188,547,874 RGD:1624291
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
G Triap1 TP53 regulated inhibitor of apoptosis 1 JBrowse link 12 46,987,404 46,989,906 RGD:1624291
G Zfp385a zinc finger protein 385A JBrowse link 7 144,939,616 144,966,364 RGD:1624291
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bdkrb2 bradykinin receptor B2 JBrowse link 6 129,399,468 129,429,676 RGD:1624291
RGD:1600115
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Msx1 msh homeobox 1 JBrowse link 14 77,712,262 77,716,061 RGD:1624291
G Rpl11 ribosomal protein L11 JBrowse link 5 154,390,809 154,394,412 RGD:1624291
RGD:1600115
G Rps7 ribosomal protein S7 JBrowse link 6 47,899,525 47,904,389 RGD:1624291
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 JBrowse link 2 250,709,812 250,744,216 RGD:1624291
G Ubb ubiquitin B JBrowse link 10 48,880,231 48,881,896 RGD:1624291
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rpl26 ribosomal protein L26 JBrowse link 10 55,492,417 55,495,547 RGD:1624291
G Steap3 STEAP3 metalloreductase JBrowse link 13 36,257,220 36,274,144 RGD:1624291
G Tp73 tumor protein p73 JBrowse link 5 171,355,876 171,415,354 RGD:1624291
regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ankrd2 ankyrin repeat domain 2 JBrowse link 1 261,281,859 261,291,307 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hnrnpk heterogeneous nuclear ribonucleoprotein K JBrowse link 17 6,664,730 6,676,753 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    cellular process 18617
      signal transduction 6968
        intracellular signal transduction 2597
          intrinsic apoptotic signaling pathway 300
            intrinsic apoptotic signaling pathway by p53 class mediator 79
              intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + 44
              intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator + 1
              negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 22
              positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 8
              regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 32
Path 2
Term Annotations click to browse term
  biological_process 19858
    biological regulation 13636
      regulation of biological process 12959
        regulation of cellular process 12442
          signal transduction 6968
            intracellular signal transduction 2597
              intrinsic apoptotic signaling pathway 300
                intrinsic apoptotic signaling pathway by p53 class mediator 79
                  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + 44
                  intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator + 1
                  negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 22
                  positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 8
                  regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 32
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.