ONTOLOGY REPORT - ANNOTATIONS


Term:protein activation cascade
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Accession:GO:0072376 term browser browse the term
Definition:A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events.
Synonyms:exact_synonym: protein activation pathway;   protein activitory cascade


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protein activation cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mvp major vault protein JBrowse link 1 198,420,813 198,448,612 RGD:1624291
blood coagulation, common pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fga fibrinogen alpha chain JBrowse link 2 181,997,562 182,013,726 RGD:1624291
RGD:1600115
blood coagulation, extrinsic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F5 coagulation factor V JBrowse link 13 82,479,997 82,535,540 RGD:1601118
blood coagulation, fibrin clot formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F13a1 coagulation factor XIII A1 chain JBrowse link 17 28,504,650 28,680,015 RGD:1600115
RGD:1624291
G Fbln1 fibulin 1 JBrowse link 7 126,096,793 126,176,468 RGD:1624291
RGD:1600115
G Fga fibrinogen alpha chain JBrowse link 2 181,997,562 182,013,726 RGD:1624291
G Fgb fibrinogen beta chain JBrowse link 2 182,028,044 182,035,026 RGD:1624291
RGD:1600115
G Fgg fibrinogen gamma chain JBrowse link 2 181,987,080 181,994,523 RGD:1624291
RGD:1600115
blood coagulation, intrinsic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoh apolipoprotein H JBrowse link 10 96,640,013 96,653,939 RGD:1624291
RGD:1600115
G F8 coagulation factor VIII JBrowse link 18 367,862 399,242 RGD:1582368
RGD:13792537
G Klkb1 kallikrein B1 JBrowse link 16 50,151,127 50,175,407 RGD:1600115
Factor XII activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F12 coagulation factor XII JBrowse link 17 9,736,577 9,744,420 RGD:1624291
RGD:1600115
G Kng2 kininogen 2 JBrowse link 11 81,509,185 81,516,759 RGD:11062094
plasma kallikrein-kinin cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F12 coagulation factor XII JBrowse link 17 9,736,577 9,744,420 RGD:1624291
G Prcp prolylcarboxypeptidase JBrowse link 1 157,701,089 157,750,177 RGD:1624291
RGD:1600115
regulation of blood coagulation, intrinsic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Serpinc1 serpin family C member 1 JBrowse link 13 78,806,107 78,820,375 RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17896
    response to stimulus 9794
      protein activation cascade 14
        blood coagulation, common pathway + 1
        blood coagulation, extrinsic pathway + 1
        blood coagulation, fibrin clot formation + 10
        blood coagulation, intrinsic pathway + 4
        kinin cascade + 3
        negative regulation of protein activation cascade + 0
        positive regulation of protein activation cascade + 0
        regulation of protein activation cascade + 1
Path 2
Term Annotations click to browse term
  biological_process 17896
    metabolic process 10654
      organic substance metabolic process 10100
        macromolecule metabolic process 8669
          protein metabolic process 5520
            protein activation cascade 14
              blood coagulation, common pathway + 1
              blood coagulation, extrinsic pathway + 1
              blood coagulation, fibrin clot formation + 10
              blood coagulation, intrinsic pathway + 4
              kinin cascade + 3
              negative regulation of protein activation cascade + 0
              positive regulation of protein activation cascade + 0
              regulation of protein activation cascade + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.