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ONTOLOGY REPORT - ANNOTATIONS


Term:protein activation cascade
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Accession:GO:0072376 term browser browse the term
Definition:A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events.
Synonyms:exact_synonym: protein activation pathway;   protein activitory cascade


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blood coagulation, common pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FGA fibrinogen alpha chain JBrowse link 4 154,583,126 154,590,742 RGD:2290271
blood coagulation, extrinsic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F10 coagulation factor X JBrowse link 13 113,122,799 113,149,529 RGD:2290271
G F3 coagulation factor III, tissue factor JBrowse link 1 94,529,173 94,541,857 RGD:2290271
G F7 coagulation factor VII JBrowse link 13 113,105,773 113,120,685 RGD:2290271
G TFPI tissue factor pathway inhibitor JBrowse link 2 187,464,230 187,554,505 RGD:2290271
blood coagulation, fibrin clot formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F13A1 coagulation factor XIII A chain JBrowse link 6 6,144,084 6,320,662 RGD:2290271
G FBLN1 fibulin 1 JBrowse link 22 45,502,883 45,601,135 RGD:2290271
G FGA fibrinogen alpha chain JBrowse link 4 154,583,126 154,590,742 RGD:2290271
G FGB fibrinogen beta chain JBrowse link 4 154,562,980 154,572,763 RGD:2290271
G FGG fibrinogen gamma chain JBrowse link 4 154,604,134 154,612,808 RGD:2290271
blood coagulation, intrinsic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2M alpha-2-macroglobulin JBrowse link 12 9,067,708 9,116,229 RGD:2290271
G APOH apolipoprotein H JBrowse link 17 66,212,033 66,229,415 RGD:2290271
G C1QBP complement C1q binding protein JBrowse link 17 5,432,777 5,439,155 RGD:2290271
G F11 coagulation factor XI JBrowse link 4 186,265,964 186,290,727 RGD:2290271
G F12 coagulation factor XII JBrowse link 5 177,402,138 177,409,576 RGD:2290271
G F2 coagulation factor II, thrombin JBrowse link 11 46,719,201 46,739,506 RGD:2290271
G F8 coagulation factor VIII JBrowse link X 154,835,788 155,022,723 RGD:2290271
G F9 coagulation factor IX JBrowse link X 139,530,720 139,563,459 RGD:2290271
G GP1BA glycoprotein Ib platelet subunit alpha JBrowse link 17 4,932,277 4,935,023 RGD:2290271
G GP1BB glycoprotein Ib platelet subunit beta JBrowse link 22 19,723,539 19,724,771 RGD:2290271
G GP5 glycoprotein V platelet JBrowse link 3 194,394,821 194,399,266 RGD:2290271
G GP9 glycoprotein IX platelet JBrowse link 3 129,055,449 129,062,411 RGD:2290271
G KLKB1 kallikrein B1 JBrowse link 4 186,215,714 186,258,477 RGD:2290271
G KNG1 kininogen 1 JBrowse link 3 186,717,359 186,744,410 RGD:2290271
G PRCP prolylcarboxypeptidase JBrowse link 11 82,822,936 82,901,740 RGD:2290271
G SERPING1 serpin family G member 1 JBrowse link 11 57,597,685 57,614,848 RGD:2290271
G VWF von Willebrand factor JBrowse link 12 5,948,874 6,124,675 RGD:2290271
Factor XII activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F12 coagulation factor XII JBrowse link 5 177,402,138 177,409,576 RGD:2290271
G KLKB1 kallikrein B1 JBrowse link 4 186,215,714 186,258,477 RGD:2290271
negative regulation of blood coagulation, common pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FGA fibrinogen alpha chain JBrowse link 4 154,583,126 154,590,742 RGD:2290271
plasma kallikrein-kinin cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F12 coagulation factor XII JBrowse link 5 177,402,138 177,409,576 RGD:2290271
G PRCP prolylcarboxypeptidase JBrowse link 11 82,822,936 82,901,740 RGD:2290271
regulation of blood coagulation, intrinsic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SERPINC1 serpin family C member 1 JBrowse link 1 173,903,519 173,917,378 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17738
    response to stimulus 9407
      protein activation cascade 27
        blood coagulation, common pathway + 1
        blood coagulation, extrinsic pathway + 4
        blood coagulation, fibrin clot formation + 27
        blood coagulation, intrinsic pathway + 18
        kinin cascade + 3
        negative regulation of protein activation cascade + 1
        positive regulation of protein activation cascade + 0
        regulation of protein activation cascade + 2
Path 2
Term Annotations click to browse term
  biological_process 17738
    metabolic process 11420
      organic substance metabolic process 10854
        macromolecule metabolic process 9356
          protein metabolic process 5846
            protein activation cascade 27
              blood coagulation, common pathway + 1
              blood coagulation, extrinsic pathway + 4
              blood coagulation, fibrin clot formation + 27
              blood coagulation, intrinsic pathway + 18
              kinin cascade + 3
              negative regulation of protein activation cascade + 1
              positive regulation of protein activation cascade + 0
              regulation of protein activation cascade + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.