Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:T-helper 17 type immune response
go back to main search page
Accession:GO:0072538 term browser browse the term
Definition:An immune response which is associated with resistance to intracellular bacteria with a key role in inflammation and tissue injury. This immune response is associated with pathological autoimmune conditions such as multiple sclerosis, arthritis and psoriasis which is typically orchestrated by the production of particular cytokines by T-helper 17 cells, most notably interleukin-17, IL-21 and IL-22.
Synonyms:exact_synonym: Th17 immune response


show annotations for term's descendants           Sort by:
 
T-helper 17 type immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Phb prohibitin ISO
ISS
(PMID:31899195)
GO_REF:0000024
RGD
UniProt
PMID:31899195 GO_REF:0000024 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO (PMID:31899195) RGD PMID:31899195 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 ISO (PMID:23169781) RGD PMID:23169781 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Il2 interleukin 2 ISO RNAcentral:URS000039ED8D_10090 (MGI:MGI:5634593|PMID:25642768) RGD PMID:25642768 MGI:MGI:5634593 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 ISO
IBA
(MGI:MGI:3817792|PMID:18792410)
PMID:21873635
RGD PMID:18792410, PMID:21873635 MGI:MGI:3817792, RGD:13792537 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 ISO (MGI:MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:MGI:6142401 NCBI chr13:78,723,028...78,794,663
Ensembl chr13:78,722,763...78,789,266
JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 ISO (MGI:MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:MGI:6142401 NCBI chr 3:21,621,976...21,676,789
Ensembl chr 3:21,623,041...21,670,014
JBrowse link
G Smad7 SMAD family member 7 IEA
ISO
GO_REF:0000107
(MGI:MGI:5634593|PMID:25642768)
Ensembl
RGD
PMID:25642768 GO_REF:0000107, MGI:MGI:5634593 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Tbx21 T-box transcription factor 21 ISO (MGI:MGI:4868293|PMID:21151104) RGD PMID:21151104 MGI:MGI:4868293 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331
JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B ISO MGI:MGI:3530739 (MGI:MGI:5450776|PMID:23034280) RGD PMID:23034280 MGI:MGI:5450776 NCBI chr 2:188,704,989...188,719,674
Ensembl chr 2:188,704,687...188,718,704
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A ISS
ISO
GO_REF:0000024
(MGI:MGI:6142401|PMID:25282160)
UniProt
RGD
PMID:25282160 GO_REF:0000024, MGI:MGI:6142401 NCBI chr 5:143,111,342...143,120,131
Ensembl chr 5:143,111,074...143,120,165
JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Loxl3 lysyl oxidase-like 3 ISO (MGI:MGI:5825383|PMID:28065600) RGD PMID:28065600 MGI:MGI:5825383 NCBI chr 4:113,866,782...113,883,713
Ensembl chr 4:113,866,804...113,883,477
JBrowse link
G Tbx21 T-box transcription factor 21 ISO (MGI:MGI:4868293|PMID:21151104) RGD PMID:21151104 MGI:MGI:4868293 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331
JBrowse link
G Tnfsf18 TNF superfamily member 18 ISO (MGI:MGI:5551556|PMID:24107315) RGD PMID:24107315 MGI:MGI:5551556 NCBI chr13:79,378,412...79,388,687
Ensembl chr13:79,378,733...79,388,498
JBrowse link
negative regulation of T-helper 17 type immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il27ra interleukin 27 receptor subunit alpha ISO UniProtKB:P35951 (MGI:MGI:5581894|PMID:22927332) RGD PMID:22927332 MGI:MGI:5581894 NCBI chr19:25,151,835...25,163,995
Ensembl chr19:25,149,897...25,164,086
JBrowse link
G Smad7 SMAD family member 7 ISO (MGI:MGI:5634593|PMID:25642768) RGD PMID:25642768 MGI:MGI:5634593 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Malt1 MALT1 paracaspase ISO (MGI:MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:MGI:6142401 NCBI chr18:61,108,712...61,162,446
Ensembl chr18:61,109,069...61,162,445
JBrowse link
G Mir326 microRNA 326 ISO (MGI:MGI:4436838|PMID:19838199) RGD PMID:19838199 MGI:MGI:4436838 NCBI chr 1:164,518,401...164,518,495
Ensembl chr 1:164,518,401...164,518,495
JBrowse link
G Nfkbid NFKB inhibitor delta ISO (MGI:MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:MGI:6142401 NCBI chr 1:88,883,816...88,892,543
Ensembl chr 1:88,885,937...88,892,615
JBrowse link
G Nfkbiz NFKB inhibitor zeta ISO (MGI:MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:MGI:6142401 NCBI chr11:47,243,342...47,271,487
Ensembl chr11:47,243,342...47,271,487
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO (MGI:MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:MGI:5689221 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il23a interleukin 23 subunit alpha ISO
IBA
(MGI:MGI:3851279|PMID:19501566)
PMID:21873635
RGD PMID:19501566, PMID:21873635 MGI:MGI:3851279, RGD:13792537 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
positive regulation of T-helper 17 type immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arid5a AT-rich interaction domain 5A ISO (MGI:MGI:5780752|PMID:27022145) RGD PMID:27022145 MGI:MGI:5780752 NCBI chr 9:42,871,907...42,886,725
Ensembl chr 9:42,871,950...42,884,855
JBrowse link
G Il23a interleukin 23 subunit alpha ISO (MGI:MGI:3851279|PMID:19501566) RGD PMID:19501566 MGI:MGI:3851279 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Mir301a microRNA 301a ISO (MGI:MGI:5426073|PMID:22517757) RGD PMID:22517757 MGI:MGI:5426073 NCBI chr10:74,417,746...74,417,845
Ensembl chr10:74,417,746...74,417,845
JBrowse link
G Nlrp10 NLR family, pyrin domain containing 10 ISO (MGI:MGI:5449483|PMID:23071280) RGD PMID:23071280 MGI:MGI:5449483 NCBI chr 1:173,521,412...173,528,969
Ensembl chr 1:173,520,413...173,528,943
JBrowse link
G Prkcq protein kinase C, theta IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:3769226|PMID:16493044)
Ensembl
UniProt
RGD
PMID:16493044 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3769226 NCBI chr17:70,971,915...71,105,286
Ensembl chr17:70,971,915...71,105,286
JBrowse link
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl20 C-C motif chemokine ligand 20 NOT ISO (MGI:MGI:3820359|PMID:19050256) RGD PMID:19050256 MGI:MGI:3820359 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 NOT ISO (MGI:MGI:3820359|PMID:19050256) RGD PMID:19050256 MGI:MGI:3820359 NCBI chr 1:53,063,380...53,087,519
Ensembl chr 1:53,065,025...53,087,474
JBrowse link
G Mir301a microRNA 301a ISO (MGI:MGI:5426073|PMID:22517757) RGD PMID:22517757 MGI:MGI:5426073 NCBI chr10:74,417,746...74,417,845
Ensembl chr10:74,417,746...74,417,845
JBrowse link
regulation of T-helper 17 type immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 NOT ISO (MGI:MGI:5688819|PMID:25065622) RGD PMID:25065622 MGI:MGI:5688819 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
G Otud5 OTU deubiquitinase 5 ISO MGI:MGI:2386448|MGI:MGI:5752247 (MGI:MGI:5621075|PMID:25470037) RGD PMID:25470037 MGI:MGI:5621075 NCBI chr  X:15,471,212...15,504,372
Ensembl chr  X:15,471,211...15,504,165
JBrowse link
T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor ISS
ISO
GO_REF:0000024
(MGI:MGI:4456325|PMID:20421391), (MGI:MGI:5004732|PMID:21572431)
UniProt
RGD
PMID:20421391, PMID:21572431 GO_REF:0000024, MGI:MGI:4456325, MGI:MGI:5004732 NCBI chr 6:109,562,415...109,584,541
Ensembl chr 6:109,562,587...109,584,545
JBrowse link
G Rora RAR-related orphan receptor A ISO (MGI:MGI:3772713|PMID:18164222) RGD PMID:18164222 MGI:MGI:3772713 NCBI chr 8:75,515,886...75,616,477
Ensembl chr 8:75,516,904...75,607,212
JBrowse link
G Rorc RAR-related orphan receptor C ISO (MGI:MGI:3692468|PMID:16990136), (MGI:MGI:3772713|PMID:18164222), (MGI:MGI:3817792|PMID:18792410) RGD PMID:16990136, PMID:18164222, PMID:18792410 MGI:MGI:3692468, MGI:MGI:3772713, MGI:MGI:3817792 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor ISS
ISO
GO_REF:0000024
(MGI:MGI:3851267|PMID:19578362), (MGI:MGI:5448096|PMID:22983707)
UniProt
RGD
PMID:19578362, PMID:22983707 GO_REF:0000024, MGI:MGI:3851267, MGI:MGI:5448096 NCBI chr 6:109,562,415...109,584,541
Ensembl chr 6:109,562,587...109,584,545
JBrowse link
G Il6 interleukin 6 ISS
ISO
GO_REF:0000024
(MGI:MGI:3692468|PMID:16990136), (MGI:MGI:6142555|PMID:27893700)
UniProt
RGD
PMID:16990136, PMID:27893700 GO_REF:0000024, MGI:MGI:3692468, MGI:MGI:6142555 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:MGI:6142555|PMID:27893700)
UniProt
Ensembl
RGD
PMID:27893700 GO_REF:0000024, GO_REF:0000107, MGI:MGI:6142555 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Irf4 interferon regulatory factor 4 ISO (MGI:MGI:5448096|PMID:22983707) RGD PMID:22983707 MGI:MGI:5448096 NCBI chr17:34,886,746...34,905,191
Ensembl chr17:34,886,739...34,905,117
JBrowse link
G Ly9 lymphocyte antigen 9 ISO (PMID:22184727) RGD PMID:22184727 NCBI chr13:90,002,779...90,022,346
Ensembl chr13:90,002,783...90,022,269
JBrowse link
G Otud5 OTU deubiquitinase 5 ISO MGI:MGI:2386448|MGI:MGI:5752247 (MGI:MGI:5621075|PMID:25470037) RGD PMID:25470037 MGI:MGI:5621075 NCBI chr  X:15,471,212...15,504,372
Ensembl chr  X:15,471,211...15,504,165
JBrowse link
G Slamf6 SLAM family member 6 ISO (PMID:22184727) RGD PMID:22184727 NCBI chr13:90,300,160...90,321,781
Ensembl chr13:90,301,006...90,322,457
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO
ISS
(MGI:MGI:5825383|PMID:28065600)
GO_REF:0000024
RGD
UniProt
PMID:28065600 GO_REF:0000024, MGI:MGI:5825383 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    response to stimulus 10568
      immune response 1748
        adaptive immune response 507
          adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 415
            T-helper 17 type immune response 36
              T-helper 17 cell differentiation + 30
              negative regulation of T-helper 17 type immune response + 12
              positive regulation of T-helper 17 type immune response + 10
              regulation of T-helper 17 type immune response + 26
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.