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ONTOLOGY REPORT - ANNOTATIONS


Term:T-helper 17 cell differentiation
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Accession:GO:0072539 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:related_synonym: T-helper 17 cell development


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T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Batf basic leucine zipper ATF-like transcription factor JBrowse link 6 109,562,415 109,584,541 RGD:1600115
RGD:1624291
G Rora RAR-related orphan receptor A JBrowse link 8 75,515,886 75,616,477 RGD:1624291
G Rorc RAR-related orphan receptor C JBrowse link 2 195,612,471 195,636,797 RGD:1624291
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link X 15,753,175 15,768,648 RGD:1624291
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:1624291
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link 13 78,723,028 78,794,663 RGD:1624291
G Rc3h2 ring finger and CCCH-type domains 2 JBrowse link 3 21,621,976 21,676,789 RGD:1624291
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:1600115
RGD:1624291
G Tbx21 T-box transcription factor 21 JBrowse link 10 85,032,799 85,049,331 RGD:1624291
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link 2 188,704,989 188,719,674 RGD:1624291
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 5 143,111,342 143,120,131 RGD:1600115
RGD:1624291
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Loxl3 lysyl oxidase-like 3 JBrowse link 4 113,866,782 113,883,713 RGD:1624291
G Tbx21 T-box transcription factor 21 JBrowse link 10 85,032,799 85,049,331 RGD:1624291
G Tnfsf18 TNF superfamily member 18 JBrowse link 13 79,378,412 79,388,687 RGD:1624291
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Malt1 MALT1 paracaspase JBrowse link 18 61,108,712 61,162,446 RGD:1624291
G Mir326 microRNA 326 JBrowse link 1 164,518,401 164,518,495 RGD:1624291
G Nfkbid NFKB inhibitor delta JBrowse link 1 88,883,816 88,892,543 RGD:1624291
G Nfkbiz NFKB inhibitor zeta JBrowse link 11 47,243,342 47,271,487 RGD:1624291
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 10 45,884,324 45,918,290 RGD:1624291
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:1624291
RGD:13792537
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl20 C-C motif chemokine ligand 20 JBrowse link 9 88,918,359 88,921,017 RGD:1624291
G Ccr6 C-C motif chemokine receptor 6 JBrowse link 1 53,063,380 53,087,519 RGD:1624291
G Mir301a microRNA 301a JBrowse link 10 74,417,746 74,417,845 RGD:1624291
T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Batf basic leucine zipper ATF-like transcription factor JBrowse link 6 109,562,415 109,584,541 RGD:1600115
RGD:1624291
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1624291
RGD:1600115
G Irf4 interferon regulatory factor 4 JBrowse link 17 34,886,746 34,905,191 RGD:1624291
G Ly9 lymphocyte antigen 9 JBrowse link 13 90,002,779 90,022,346 RGD:1624291
G Otud5 OTU deubiquitinase 5 JBrowse link X 15,471,212 15,504,372 RGD:1624291
G Slamf6 SLAM family member 6 JBrowse link 13 90,300,160 90,321,781 RGD:1624291
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19439
    immune system process 2631
      immune response 1575
        adaptive immune response 485
          adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 408
            T-helper 17 type immune response 34
              T-helper 17 cell differentiation 29
                T-helper 17 cell lineage commitment + 11
                negative regulation of T-helper 17 cell differentiation + 11
                positive regulation of T-helper 17 cell differentiation + 6
                regulation of T-helper 17 cell differentiation + 20
Path 2
Term Annotations click to browse term
  biological_process 19439
    developmental process 6673
      anatomical structure development 6138
        multicellular organism development 5605
          system development 5126
            animal organ development 3916
              hematopoietic or lymphoid organ development 976
                hemopoiesis 924
                  leukocyte differentiation 571
                    lymphocyte differentiation 389
                      T cell differentiation 276
                        alpha-beta T cell differentiation 119
                          CD4-positive, alpha-beta T cell differentiation 83
                            CD4-positive, alpha-beta T cell differentiation involved in immune response 64
                              T-helper cell differentiation 62
                                T-helper 17 cell differentiation 29
                                  T-helper 17 cell lineage commitment + 11
                                  negative regulation of T-helper 17 cell differentiation + 11
                                  positive regulation of T-helper 17 cell differentiation + 6
                                  regulation of T-helper 17 cell differentiation + 20
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.