Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:clathrin-dependent endocytosis
go back to main search page
Accession:GO:0072583 term browser browse the term
Definition:An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles.
Synonyms:exact_synonym: CME;   clathrin coated pit-dependent endocytosis;   clathrin-mediated endocytosis


show annotations for term's descendants           Sort by:
 
clathrin-dependent endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 ISO
IBA
(PMID:22262466), (PMID:23676497)
PMID:21873635
(MGI:5514106|PMID:23676497)
RGD PMID:22262466, PMID:23676497, PMID:21873635 MGI:5514106, RGD:13792537 NCBI chr 1:100,896,582...100,926,443
Ensembl chr 1:100,896,947...100,926,335
JBrowse link
G Ap2a2 adaptor related protein complex 2 subunit alpha 2 IEA
IBA
ISO
ISS
GO_REF:0000002
PMID:21873635
(MGI:5514106|PMID:23676497)
GO_REF:0000024
(PMID:22262466), (PMID:23676497)
GO_REF:0000107
InterPro
RGD
UniProt
Ensembl
PMID:22262466, PMID:23676497, PMID:21873635 GO_REF:0000002, GO_REF:0000024, GO_REF:0000107, MGI:5514106, RGD:13792537 NCBI chr 1:214,534,217...214,607,497
Ensembl chr 1:214,534,284...214,606,169
JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 ISO (PMID:23676497)
(MGI:5514106|PMID:23676497)
RGD PMID:23676497 MGI:5514106 NCBI chr10:70,516,462...70,621,973
Ensembl chr10:70,520,206...70,621,977
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 ISO
IBA
(PMID:23676497), (PMID:31104773)
PMID:21873635
(MGI:5514106|PMID:23676497)
RGD PMID:23676497, PMID:31104773, PMID:21873635 MGI:5514106, RGD:13792537 NCBI chr11:84,041,184...84,047,542
Ensembl chr11:84,041,184...84,047,546
JBrowse link
G Ap2s1 adaptor related protein complex 2 subunit sigma 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:78,671,238...78,682,847
Ensembl chr 1:78,671,121...78,682,871
JBrowse link
G Canx calnexin ISS
ISO
GO_REF:0000024
(MGI:5288282|PMID:21747946)
UniProt
RGD
PMID:21747946 GO_REF:0000024, MGI:5288282 NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861
JBrowse link
G Clta clathrin, light chain A IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:59,490,689...59,509,139
Ensembl chr 5:59,491,096...59,509,138
JBrowse link
G Cltb clathrin, light chain B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:10,537,348...10,554,999
Ensembl chr17:10,537,365...10,554,989
JBrowse link
G Cltc clathrin heavy chain ISO (PMID:26005850) RGD PMID:26005850 NCBI chr10:74,014,560...74,070,578
Ensembl chr10:74,014,562...74,070,266
JBrowse link
G Dll1 delta like canonical Notch ligand 1 IDA PMID:22658936 UniProt PMID:22658936 RGD:10402035 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379
JBrowse link
G Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:120,330,372...120,492,515
Ensembl chr 5:120,340,646...120,492,487
JBrowse link
G Fcho1 FCH and mu domain containing endocytic adaptor 1 ISO
IBA
(PMID:20448150)
PMID:21873635
RGD PMID:20448150, PMID:21873635 RGD:13792537 NCBI chr16:20,136,008...20,153,344
Ensembl chr16:20,136,008...20,148,867
JBrowse link
G Fcho2 FCH and mu domain containing endocytic adaptor 2 ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:20448150), (PMID:21762413)
UniProt
RGD
PMID:20448150, PMID:21762413, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 2:28,927,918...29,029,271
Ensembl chr 2:28,926,107...29,029,176
JBrowse link
G Fchsd2 FCH and double SH3 domains 2 ISO (PMID:29887380) RGD PMID:29887380 NCBI chr 1:166,140,025...166,395,915
Ensembl chr 1:166,125,474...166,395,915
JBrowse link
G Fnbp1l formin binding protein 1-like ISO (PMID:20730103) RGD PMID:20730103 NCBI chr 2:226,691,435...226,742,081
Ensembl chr 2:226,688,844...226,779,440
JBrowse link
G Gak cyclin G associated kinase IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
MGI:5305733 (MGI:4439191|PMID:20160091), (MGI:5305417|PMID:18434600)
(PMID:16155256)
Ensembl
RGD
PMID:16155256, PMID:18434600, PMID:20160091, PMID:21873635 GO_REF:0000107, MGI:4439191, MGI:5305417, RGD:13792537 NCBI chr14:2,100,104...2,174,332
Ensembl chr14:2,100,106...2,174,318
JBrowse link
G Gpr107 G protein-coupled receptor 107 ISO
IBA
(MGI:5604949|PMID:24849652)
PMID:21873635
RGD PMID:24849652, PMID:21873635 MGI:5604949, RGD:13792537 NCBI chr 3:10,632,876...10,694,654
Ensembl chr 3:10,632,896...10,694,649
JBrowse link
G Hip1 huntingtin interacting protein 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr12:24,180,795...24,315,373
Ensembl chr12:24,180,937...24,315,373
JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F ISO (MGI:5763358|PMID:25869668) RGD PMID:25869668 MGI:5763358 NCBI chr 1:200,037,749...200,116,524
Ensembl chr 1:200,037,749...200,116,524
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein IEA
IBA
ISO
ISS
GO_REF:0000107
PMID:21873635
(MGI:5432454|PMID:22539346)
(PMID:22952941), (PMID:24577224), (PMID:26005850)
GO_REF:0000024
Ensembl
RGD
Alzheimers_University_of_Toronto
PMID:22539346, PMID:22952941, PMID:24577224, PMID:26005850, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:5432454, RGD:13792537 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
JBrowse link
G Sgip1 SH3GL interacting endocytic adaptor 1 IEA
IBA
GO_REF:0000002
PMID:21873635
InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr 5:122,300,415...122,498,478
Ensembl chr 5:122,390,522...122,491,203
JBrowse link
G Siglec1 sialic acid binding Ig like lectin 1 ISO (PMID:21359217) RGD PMID:21359217 NCBI chr 3:123,612,067...123,631,718
Ensembl chr 3:123,612,067...123,631,109
JBrowse link
G Slc9b2 solute carrier family 9 member B2 ISO (MGI:5492253|PMID:23720317) RGD PMID:23720317 MGI:5492253 NCBI chr 2:240,485,254...240,519,166
Ensembl chr 2:240,495,371...240,519,141
JBrowse link
G Snap91 synaptosome associated protein 91 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:94,447,558...94,564,772
Ensembl chr 8:94,447,550...94,564,525
JBrowse link
clathrin-dependent endocytosis of virus by host cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Siglec1 sialic acid binding Ig like lectin 1 ISO
IBA
(PMID:12857889)
PMID:21873635
RGD PMID:12857889, PMID:21873635 RGD:13792537 NCBI chr 3:123,612,067...123,631,718
Ensembl chr 3:123,612,067...123,631,109
JBrowse link
clathrin-dependent extracellular exosome endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itga4 integrin subunit alpha 4 IMP RGD PMID:20124479 RGD:9698434 NCBI chr 3:66,178,745...66,265,547
Ensembl chr 3:66,193,059...66,263,960
JBrowse link
clathrin-dependent synaptic vesicle endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btbd8 BTB domain containing 8 ISS
ISO
IEA
GO_REF:0000024
(MGI:6104538|PMID:29262337)
GO_REF:0000002
UniProt
RGD
InterPro
PMID:29262337 GO_REF:0000002, GO_REF:0000024, MGI:6104538 NCBI chr14:3,282,422...3,351,740
Ensembl chr14:3,284,089...3,300,200
JBrowse link
G Itsn1 intersectin 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:31,943,119...32,069,249
Ensembl chr11:31,893,489...32,069,249
JBrowse link
G Itsn2 intersectin 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:30,098,378...30,208,694
Ensembl chr 6:30,098,380...30,187,337
JBrowse link
negative regulation of clathrin-dependent endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Neu3 neuraminidase 3 ISO
IEA
(PMID:26251452)
GO_REF:0000107
RGD
Ensembl
PMID:26251452 GO_REF:0000107 NCBI chr 1:164,803,574...164,814,777
Ensembl chr 1:164,803,574...164,814,651
JBrowse link
G Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 IMP RGD PMID:15066995 RGD:13504745 NCBI chr 1:144,069,641...144,200,402
Ensembl chr 1:144,069,638...144,200,397
JBrowse link
G Syt11 synaptotagmin 11 IMP PMID:26589353 ParkinsonsUK-UCL PMID:26589353 RGD:11079192 NCBI chr 2:188,112,301...188,138,180
Ensembl chr 2:188,112,286...188,138,177
JBrowse link
G Ubqln2 ubiquilin 2 ISO (PMID:18199683) RGD PMID:18199683 NCBI chr  X:18,723,313...18,726,732
Ensembl chr  X:18,723,341...18,726,732
JBrowse link
G Unc119 unc-119 lipid binding chaperone ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(MGI:5559669|PMID:19781630)
UniProt
RGD
PMID:19781630, PMID:21873635 GO_REF:0000024, MGI:5559669, RGD:13792537 NCBI chr10:65,606,919...65,612,324
Ensembl chr10:65,606,898...65,612,324
JBrowse link
positive regulation of clathrin-dependent endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dab2 DAB adaptor protein 2 IEA
ISO
GO_REF:0000107
(MGI:5442508|PMID:16984970)
Ensembl
RGD
PMID:16984970 GO_REF:0000107, MGI:5442508 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
JBrowse link
G Dgkd diacylglycerol kinase, delta ISO (PMID:17880279) RGD PMID:17880279 NCBI chr 9:94,980,328...95,071,531
Ensembl chr 9:94,980,409...95,069,714
JBrowse link
G Dnm2 dynamin 2 IMP RGD PMID:11925437 RGD:728683 NCBI chr 8:22,458,869...22,540,649
Ensembl chr 8:22,458,899...22,540,524
JBrowse link
G Scyl2 SCY1 like pseudokinase 2 ISO (PMID:19643732) RGD PMID:19643732 NCBI chr 7:30,291,087...30,344,464
Ensembl chr 7:30,291,087...30,344,445
JBrowse link
G Wasl WASP like actin nucleation promoting factor IDA PMID:20730103 BHF-UCL PMID:20730103 RGD:8554834 NCBI chr 4:51,677,722...51,726,212
Ensembl chr 4:51,677,722...51,726,212
JBrowse link
regulation of clathrin-dependent endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aak1 AP2 associated kinase 1 IDA
IBA
ISO
IEA
PMID:11877461
PMID:21873635
(PMID:17494869), (PMID:18657069)
GO_REF:0000107
RGD
Ensembl
PMID:17494869, PMID:18657069, PMID:11877461, PMID:21873635 GO_REF:0000107, RGD:8553925, RGD:13792537 NCBI chr 4:118,653,851...118,806,796
Ensembl chr 4:118,655,728...118,795,774
JBrowse link
G Bmp2k BMP-2 inducible kinase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:14,126,086...14,226,823
Ensembl chr14:14,129,725...14,192,048
JBrowse link
G Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 ISO MGI:4440489 (MGI:4439191|PMID:20160091) RGD PMID:20160091 MGI:4439191 NCBI chr 5:120,330,372...120,492,515
Ensembl chr 5:120,340,646...120,492,487
JBrowse link
G Hip1r huntingtin interacting protein 1 related IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr12:38,024,517...38,053,184
Ensembl chr12:38,024,519...38,053,085
JBrowse link
G Prom2 prominin 2 NOT ISO (PMID:23583380) RGD PMID:23583380 NCBI chr 3:120,087,633...120,107,495
Ensembl chr 3:120,092,582...120,106,697
JBrowse link
G Sh3gl2 SH3 domain containing GRB2 like 2, endophilin A1 IMP RGD PMID:15066995 RGD:13504745 NCBI chr 5:103,479,767...103,654,507
Ensembl chr 5:103,479,767...103,654,247
JBrowse link
G Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 IMP RGD PMID:15066995 RGD:13504745 NCBI chr 1:144,069,641...144,200,402
Ensembl chr 1:144,069,638...144,200,397
JBrowse link
G Smap1 small ArfGAP 1 ISO
IBA
(MGI:3581491|PMID:15659652)
PMID:21873635
RGD PMID:15659652, PMID:21873635 MGI:3581491, RGD:13792537 NCBI chr 9:30,068,888...30,161,753
Ensembl chr 9:30,068,659...30,161,578
JBrowse link
G Snap91 synaptosome associated protein 91 ISO
IEA
(PMID:16254249)
GO_REF:0000107
RGD
Ensembl
PMID:16254249 GO_REF:0000107 NCBI chr 8:94,447,558...94,564,772
Ensembl chr 8:94,447,550...94,564,525
JBrowse link
G Tnk2 tyrosine kinase, non-receptor, 2 ISO (PMID:18262180) RGD PMID:18262180 NCBI chr11:71,348,726...71,388,520
Ensembl chr11:71,348,717...71,387,992
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20030
    cellular process 18802
      vesicle-mediated transport 1675
        endocytosis 692
          receptor-mediated endocytosis 254
            clathrin-dependent endocytosis 45
              cargo loading involved in clathrin-dependent endocytosis 0
              clathrin coat assembly involved in endocytosis 0
              clathrin-dependent endocytosis involved in vitellogenesis 0
              clathrin-dependent endocytosis of virus by host cell 1
              clathrin-dependent extracellular exosome endocytosis 1
              clathrin-dependent synaptic vesicle endocytosis 3
              negative regulation of clathrin-dependent endocytosis 5
              nucleation of clathrin-coated pit 0
              positive regulation of clathrin-dependent endocytosis 5
              regulation of clathrin-dependent endocytosis + 19
              vesicle scission involved in clathrin-mediated endocytosis 0
Path 2
Term Annotations click to browse term
  biological_process 20030
    localization 6478
      establishment of localization 4886
        transport 4734
          vesicle-mediated transport 1675
            endocytosis 692
              receptor-mediated endocytosis 254
                clathrin-dependent endocytosis 45
                  cargo loading involved in clathrin-dependent endocytosis 0
                  clathrin coat assembly involved in endocytosis 0
                  clathrin-dependent endocytosis involved in vitellogenesis 0
                  clathrin-dependent endocytosis of virus by host cell 1
                  clathrin-dependent extracellular exosome endocytosis 1
                  clathrin-dependent synaptic vesicle endocytosis 3
                  negative regulation of clathrin-dependent endocytosis 5
                  nucleation of clathrin-coated pit 0
                  positive regulation of clathrin-dependent endocytosis 5
                  regulation of clathrin-dependent endocytosis + 19
                  vesicle scission involved in clathrin-mediated endocytosis 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.