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ONTOLOGY REPORT - ANNOTATIONS


Term:CAAX-box protein maturation
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Accession:GO:0080120 term browser browse the term
Definition:A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase.
Synonyms:related_synonym: CAAX-box protein processing;   farnesylated protein maturation


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CAAX-box protein processing term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like JBrowse link 1 169,720,247 169,721,788 RGD:1624291
G Rce1 Ras converting CAAX endopeptidase 1 JBrowse link 1 219,860,826 219,863,933 RGD:1600115
RGD:13792537
RGD:1624291
G Zmpste24 zinc metallopeptidase STE24 JBrowse link 5 139,982,404 140,015,541 RGD:13792537

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  biological_process 19317
    metabolic process 11540
      cellular metabolic process 10566
        cellular macromolecule metabolic process 8135
          cellular protein metabolic process 5303
            CAAX-box protein maturation 3
              CAAX-box protein modification 0
              CAAX-box protein processing 3
Path 2
Term Annotations click to browse term
  biological_process 19317
    metabolic process 11540
      nitrogen compound metabolic process 9888
        organonitrogen compound metabolic process 6848
          protein metabolic process 5975
            protein maturation 292
              CAAX-box protein maturation 3
                CAAX-box protein modification 0
                CAAX-box protein processing 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.