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ONTOLOGY REPORT - ANNOTATIONS


Term:membrane depolarization during action potential
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Accession:GO:0086010 term browser browse the term
Definition:The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.


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membrane depolarization during action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1g calcium voltage-gated channel subunit alpha1 G IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:82,129,071...82,197,828
Ensembl chr10:82,129,506...82,197,848
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:121,521,787...121,619,300
Ensembl chr 7:121,511,097...121,619,283
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 ISO
IEA
(PMID:7604285)
GO_REF:0000107
RGD
Ensembl
PMID:7604285 GO_REF:0000107 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:128,298,593...128,416,896
Ensembl chr 8:128,298,594...128,416,650
JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:128,450,793...128,527,510
Ensembl chr 8:128,450,801...128,521,109
JBrowse link
G Scn1a sodium voltage-gated channel alpha subunit 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:52,388,811...52,533,365
Ensembl chr 3:52,381,975...52,510,507
JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:51,687,910...51,822,008
Ensembl chr 3:51,687,809...51,822,250
JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:51,530,897...51,643,140
Ensembl chr 3:51,532,627...51,643,140
JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 ISO (PMID:20042427), (PMID:20226894), (PMID:21051419) RGD PMID:20042427, PMID:20226894, PMID:21051419 NCBI chr 8:44,136,413...44,159,011
Ensembl chr 8:44,136,496...44,159,010
JBrowse link
G Scn4a sodium voltage-gated channel alpha subunit 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:94,505,026...94,557,803
Ensembl chr10:94,505,026...94,557,764
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:14500339), (PMID:18065446), (PMID:22529811)
BHF-UCL
RGD
PMID:14500339, PMID:18065446, PMID:22529811, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Scn7a sodium voltage-gated channel alpha subunit 7 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:52,775,779...52,877,365
Ensembl chr 3:52,777,214...52,849,907
JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:142,575,629...142,683,659
Ensembl chr 7:142,575,672...142,684,114
JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:52,583,953...52,664,209
Ensembl chr 3:52,583,951...52,664,209
JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta ISO
ISS
IEA
(PMID:16728661)
GO_REF:0000024
GO_REF:0000107
RGD
BHF-UCL
Ensembl
PMID:16728661 GO_REF:0000024, GO_REF:0000107 NCBI chr14:83,053,041...83,062,424
Ensembl chr14:83,053,041...83,062,424
JBrowse link
membrane depolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO
ISS
IEA
(PMID:17224476)
GO_REF:0000024
GO_REF:0000107
RGD
BHF-UCL
Ensembl
PMID:17224476 GO_REF:0000024, GO_REF:0000107 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 ISO
ISS
IEA
(PMID:17224476)
GO_REF:0000024
GO_REF:0000107
RGD
BHF-UCL
Ensembl
PMID:17224476 GO_REF:0000024, GO_REF:0000107 NCBI chr17:81,673,862...82,019,219
Ensembl chr17:81,798,756...82,017,682
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO
IEA
(PMID:18065446)
GO_REF:0000107
RGD
Ensembl
PMID:18065446 GO_REF:0000107 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
membrane depolarization during AV node cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO
ISS
IEA
(PMID:26253506)
GO_REF:0000024
GO_REF:0000107
RGD
BHF-UCL
Ensembl
PMID:26253506 GO_REF:0000024, GO_REF:0000107 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G IEA
ISO
ISS
GO_REF:0000107
(MGI:3714901|PMID:16690884)
GO_REF:0000024
Ensembl
RGD
BHF-UCL
PMID:16690884 GO_REF:0000024, GO_REF:0000107, MGI:3714901 NCBI chr10:82,129,071...82,197,828
Ensembl chr10:82,129,506...82,197,848
JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 ISO
ISS
IEA
(PMID:17224476)
GO_REF:0000024
GO_REF:0000107
RGD
BHF-UCL
Ensembl
PMID:17224476 GO_REF:0000024, GO_REF:0000107 NCBI chr17:81,673,862...82,019,219
Ensembl chr17:81,798,756...82,017,682
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO
IEA
ISS
(PMID:18616619)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
BHF-UCL
PMID:18616619 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 IEA
ISO
GO_REF:0000107
(PMID:27207958)
Ensembl
RGD
PMID:27207958 GO_REF:0000107 NCBI chr 1:101,293,300...101,323,484
Ensembl chr 1:101,293,409...101,323,960
JBrowse link
membrane depolarization during bundle of His cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 IEA
ISO
GO_REF:0000107
(PMID:21383000)
Ensembl
RGD
PMID:21383000 GO_REF:0000107 NCBI chr 4:15,706,974...16,130,848
Ensembl chr 4:15,710,417...16,130,848
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO
IEA
ISS
(PMID:18065446)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
BHF-UCL
PMID:18065446 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 IEA
ISO
GO_REF:0000107
(PMID:27207958)
Ensembl
RGD
PMID:27207958 GO_REF:0000107 NCBI chr 1:101,293,300...101,323,484
Ensembl chr 1:101,293,409...101,323,960
JBrowse link
membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO
ISS
(PMID:15454078)
GO_REF:0000024
RGD
BHF-UCL
PMID:15454078 GO_REF:0000024 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D IC PMID:21859974 BHF-UCL PMID:21859974 RGD:6767284 NCBI chr16:6,110,294...6,405,022
Ensembl chr16:6,112,150...6,405,117
JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 ISO (MGI:3763979|PMID:17884088) RGD PMID:17884088 MGI:3763979 NCBI chr 1:89,550,738...89,560,469
Ensembl chr 1:89,550,738...89,560,719
JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 ISO (PMID:19808477) RGD PMID:19808477 NCBI chr 8:49,419,003...49,431,110
Ensembl chr 8:49,418,965...49,427,689
JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 ISO (PMID:21051419) RGD PMID:21051419 NCBI chr 8:44,136,413...44,159,011
Ensembl chr 8:44,136,496...44,159,010
JBrowse link
G Scn4b sodium voltage-gated channel beta subunit 4 ISO (PMID:17592081) RGD PMID:17592081 NCBI chr 8:49,441,106...49,456,279
Ensembl chr 8:49,441,106...49,456,279
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO
ISS
(PMID:21895525)
GO_REF:0000024
RGD
BHF-UCL
PMID:21895525 GO_REF:0000024 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
membrane depolarization during Purkinje myocyte cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn1b sodium voltage-gated channel beta subunit 1 ISO (PMID:18464934) RGD PMID:18464934 NCBI chr 1:89,550,738...89,560,469
Ensembl chr 1:89,550,738...89,560,719
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO
IEA
ISS
(PMID:22766342)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
BHF-UCL
PMID:22766342 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 IEA
ISO
GO_REF:0000107
(PMID:27207958)
Ensembl
RGD
PMID:27207958 GO_REF:0000107 NCBI chr 1:101,293,300...101,323,484
Ensembl chr 1:101,293,409...101,323,960
JBrowse link
membrane depolarization during SA node cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1d calcium voltage-gated channel subunit alpha1 D ISO
IEA
(PMID:21131953)
MGI:2180141 (MGI:3583874|PMID:12700358)
GO_REF:0000107
RGD
Ensembl
PMID:12700358, PMID:21131953 GO_REF:0000107, MGI:3583874 NCBI chr16:6,110,294...6,405,022
Ensembl chr16:6,112,150...6,405,117
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G IEA
ISO
ISS
GO_REF:0000107
(MGI:3714901|PMID:16690884)
GO_REF:0000024
Ensembl
RGD
BHF-UCL
PMID:16690884 GO_REF:0000024, GO_REF:0000107, MGI:3714901 NCBI chr10:82,129,071...82,197,828
Ensembl chr10:82,129,506...82,197,848
JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 IEA
ISO
GO_REF:0000107
(PMID:16407510)
Ensembl
RGD
PMID:16407510 GO_REF:0000107 NCBI chr 8:63,599,907...63,637,327
Ensembl chr 8:63,600,663...63,639,654
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO
IEA
ISS
(PMID:18616619)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
BHF-UCL
PMID:18616619 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
negative regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 ISO (MGI:5613732|PMID:25257915) RGD PMID:25257915 MGI:5613732 NCBI chr 4:144,382,945...144,398,919
Ensembl chr 4:144,382,945...144,398,917
JBrowse link
positive regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank3 ankyrin 3 IMP PMID:18180363 BHF-UCL PMID:18180363 RGD:6767295 NCBI chr20:19,948,767...20,480,628
Ensembl chr20:20,105,047...20,480,623
JBrowse link
regulation of membrane depolarization during action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 ISO (PMID:16930557) RGD PMID:16930557 NCBI chr 5:74,248,996...74,368,167
Ensembl chr 5:74,248,996...74,368,186
JBrowse link
regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 ISO
IBA
(PMID:17275750)
PMID:21873635
RGD PMID:17275750, PMID:21873635 RGD:13792537 NCBI chr 4:144,382,945...144,398,919
Ensembl chr 4:144,382,945...144,398,917
JBrowse link
G Gja5 gap junction protein, alpha 5 ISO MGI:2445238 (MGI:1197846|PMID:9501070) RGD PMID:9501070 MGI:1197846 NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
JBrowse link
G Rangrf RAN guanine nucleotide release factor ISO (PMID:21621375) RGD PMID:21621375 NCBI chr10:55,559,049...55,560,420
Ensembl chr10:55,559,041...55,560,422
JBrowse link
G Slmap sarcolemma associated protein ISO
IEA
(PMID:23064965)
GO_REF:0000107
RGD
Ensembl
PMID:23064965 GO_REF:0000107 NCBI chr16:2,112,271...2,227,336
Ensembl chr16:2,112,274...2,227,309
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological quality 4280
        regulation of membrane potential 483
          membrane depolarization 85
            membrane depolarization during action potential 31
              membrane depolarization during cardiac muscle cell action potential + 17
              regulation of membrane depolarization during action potential + 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.