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ONTOLOGY REPORT - ANNOTATIONS


Term:membrane depolarization during bundle of His cell action potential
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Accession:GO:0086048 term browser browse the term
Definition:The process in which bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
Synonyms:exact_synonym: membrane depolarization during bundle of His cardiac muscle cell action potential


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membrane depolarization during bundle of His cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 IEA
ISO
GO_REF:0000107
(PMID:21383000)
Ensembl
RGD
PMID:21383000 GO_REF:0000107 NCBI chr 4:15,706,974...16,130,848
Ensembl chr 4:15,710,417...16,130,848
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO
IEA
ISS
(PMID:18065446)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
BHF-UCL
PMID:18065446 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 IEA
ISO
GO_REF:0000107
(PMID:27207958)
Ensembl
RGD
PMID:27207958 GO_REF:0000107 NCBI chr 1:101,293,300...101,323,484
Ensembl chr 1:101,293,409...101,323,960
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    signaling 7580
      cell-cell signaling 1725
        cell-cell signaling involved in cardiac conduction 25
          bundle of His cell to Purkinje myocyte signaling 7
            bundle of His cell action potential 7
              membrane depolarization during bundle of His cell action potential 3
Path 2
Term Annotations click to browse term
  biological_process 20028
    multicellular organismal process 9046
      system process 3453
        circulatory system process 579
          heart process 255
            heart contraction 246
              regulation of heart contraction 199
                cardiac conduction 66
                  cell communication involved in cardiac conduction 41
                    bundle of His cell to Purkinje myocyte communication 16
                      bundle of His cell to Purkinje myocyte signaling 7
                        bundle of His cell action potential 7
                          membrane depolarization during bundle of His cell action potential 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.