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ONTOLOGY REPORT - ANNOTATIONS


Term:bundle of His cell to Purkinje myocyte communication
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Accession:GO:0086069 term browser browse the term
Definition:The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
Synonyms:exact_synonym: bundle of His cardiac muscle cell to Purkinje myocyte communication


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bundle of His cell to Purkinje myocyte communication term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnni3k TNNI3 interacting kinase ISO
ISS
(PMID:23236294)
GO_REF:0000024
RGD
BHF-UCL
PMID:23236294 GO_REF:0000024 NCBI chr 2:261,069,210...261,337,294
Ensembl chr 2:261,069,203...261,337,163
JBrowse link
bundle of His cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn10a sodium voltage-gated channel alpha subunit 10 ISO (PMID:24998131) RGD PMID:24998131 NCBI chr 8:128,298,593...128,416,896
Ensembl chr 8:128,298,594...128,416,650
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO
ISS
(PMID:18065446)
GO_REF:0000024
RGD
BHF-UCL
PMID:18065446 GO_REF:0000024 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
bundle of His cell to Purkinje myocyte communication by electrical coupling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 ISO (PMID:22247482) RGD PMID:22247482 NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
JBrowse link
bundle of His cell-Purkinje myocyte adhesion involved in cell communication term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07034767.1 IEA GO_REF:0000107 Ensembl GO_REF:0000107 Ensembl chr11:88,912,599...88,972,176 JBrowse link
G AABR07044900.1 IEA GO_REF:0000107 Ensembl GO_REF:0000107 Ensembl chr20:25,064,702...25,826,658 JBrowse link
G Ctnna3 catenin alpha 3 ISO (PMID:23136403) RGD PMID:23136403 NCBI chr20:25,063,124...26,640,428
Ensembl chr20:26,516,836...26,589,209
JBrowse link
G Dsc2 desmocollin 2 ISO (PMID:23863954) RGD PMID:23863954 NCBI chr18:11,826,705...11,858,801
Ensembl chr18:11,826,706...11,858,754
JBrowse link
G Dsg2 desmoglein 2 ISO (PMID:16505173) RGD PMID:16505173 NCBI chr18:15,579,322...15,637,720
Ensembl chr18:15,579,315...15,637,715
JBrowse link
G Dsp desmoplakin ISO (PMID:12373648) RGD PMID:12373648 NCBI chr17:27,286,811...27,334,453
Ensembl chr17:27,286,796...27,334,379
JBrowse link
G Jup junction plakoglobin ISO (PMID:17924338) RGD PMID:17924338 NCBI chr10:88,280,517...88,307,451
Ensembl chr10:88,279,632...88,307,412
JBrowse link
G Pkp2 plakophilin 2 ISO (PMID:22889254) RGD PMID:22889254 NCBI chr11:88,912,163...88,972,213 JBrowse link
membrane depolarization during bundle of His cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 IEA
ISO
GO_REF:0000107
(PMID:21383000)
Ensembl
RGD
PMID:21383000 GO_REF:0000107 NCBI chr 4:15,706,974...16,130,848
Ensembl chr 4:15,710,417...16,130,848
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO
IEA
ISS
(PMID:18065446)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
BHF-UCL
PMID:18065446 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 IEA
ISO
GO_REF:0000107
(PMID:27207958)
Ensembl
RGD
PMID:27207958 GO_REF:0000107 NCBI chr 1:101,293,300...101,323,484
Ensembl chr 1:101,293,409...101,323,960
JBrowse link
membrane repolarization during bundle of His cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcna5 potassium voltage-gated channel subfamily A member 5 ISO (PMID:23264583) RGD PMID:23264583 NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003
JBrowse link
regulation of bundle of His cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 ISO (PMID:22247482)
(MGI:MGI:3696497|PMID:10515563)
RGD PMID:10515563, PMID:22247482 MGI:MGI:3696497 NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
JBrowse link
G Rangrf RAN guanine nucleotide release factor ISO (PMID:21621375) RGD PMID:21621375 NCBI chr10:55,559,049...55,560,420
Ensembl chr10:55,559,041...55,560,422
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    cellular process 18798
      cell communication 7664
        cell communication involved in cardiac conduction 41
          bundle of His cell to Purkinje myocyte communication 16
            bundle of His cell to Purkinje myocyte communication by electrical coupling 1
            bundle of His cell to Purkinje myocyte signaling + 7
            bundle of His cell-Purkinje myocyte adhesion involved in cell communication 8
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological process 13075
        regulation of multicellular organismal process 2914
          regulation of system process 648
            regulation of blood circulation 267
              regulation of heart contraction 199
                cardiac conduction 66
                  cell communication involved in cardiac conduction 41
                    bundle of His cell to Purkinje myocyte communication 16
                      bundle of His cell to Purkinje myocyte communication by electrical coupling 1
                      bundle of His cell to Purkinje myocyte signaling + 7
                      bundle of His cell-Purkinje myocyte adhesion involved in cell communication 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.