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ONTOLOGY REPORT - ANNOTATIONS


Term:G protein-coupled receptor signaling pathway involved in heart process
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Accession:GO:0086103 term browser browse the term
Definition:An G protein-coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart.
Synonyms:exact_synonym: G-protein coupled receptor signalling pathway involved in heart process;   GPCR signaling pathway involved in cardiac process;   GPCR signaling pathway involved in heart process


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G protein-coupled receptor signaling pathway involved in heart process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ramp3 receptor activity modifying protein 3 ISS
ISO
GO_REF:0000024
(MGI:5514109|PMID:23674134)
UniProt
RGD
PMID:23674134 GO_REF:0000024, MGI:5514109 NCBI chr14:86,922,223...86,939,722
Ensembl chr14:86,922,223...86,939,719
JBrowse link
adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chga chromogranin A IDA
IBA
PMID:22459152
PMID:21873635
UniProt
GO_Central
PMID:22459152, PMID:21873635 RGD:6906968, RGD:13792537 NCBI chr 6:126,434,226...126,445,569
Ensembl chr 6:126,434,226...126,445,568
JBrowse link
adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap13 A-kinase anchoring protein 13 ISS
ISO
GO_REF:0000024
(MGI:5770047|PMID:23658642)
UniProt
RGD
PMID:23658642 GO_REF:0000024, MGI:5770047 NCBI chr 1:137,089,558...137,315,272
Ensembl chr 1:137,014,272...137,315,272
JBrowse link
G Pln phospholamban ISO MGI:2158357 (MGI:1351738|PMID:10471356) RGD PMID:10471356 MGI:1351738 NCBI chr20:34,633,157...34,642,904
Ensembl chr20:34,633,157...34,642,904
JBrowse link
adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde4d phosphodiesterase 4D IC PMID:19801680 BHF-UCL PMID:19801680 RGD:7327160 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264
JBrowse link
angiotensin-activated signaling pathway involved in heart process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 IEA
ISO
GO_REF:0000107
UniProtKB:P09470 (MGI:5607357|PMID:25017399)
Ensembl
RGD
PMID:25017399 GO_REF:0000107, MGI:5607357 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO UniProtKB:P09470|UniProtKB:P49817 (MGI:5607357|PMID:25017399) RGD PMID:25017399 MGI:5607357 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 ISO (PMID:17242280) RGD PMID:17242280 NCBI chr13:50,091,644...50,153,808
Ensembl chr13:50,091,430...50,153,823
JBrowse link
G Gnai2 G protein subunit alpha i2 IDA RGD PMID:12631586 RGD:13508593 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Pde4b phosphodiesterase 4B ISO (MGI:5286798|PMID:21670503) RGD PMID:21670503 MGI:5286798 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgs2 regulator of G-protein signaling 2 ISO (MGI:5009116|PMID:21291891) RGD PMID:21291891 MGI:5009116 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nos1 nitric oxide synthase 1 IEA
ISO
GO_REF:0000107
(MGI:3771112|PMID:17242280)
Ensembl
RGD
PMID:17242280 GO_REF:0000107, MGI:3771112 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    signaling 7579
      signal transduction 7010
        G protein-coupled receptor signaling pathway 2509
          G protein-coupled receptor signaling pathway involved in heart process 12
            G protein-coupled acetylcholine receptor signaling pathway involved in heart process + 0
            adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process + 8
            adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process + 1
            angiotensin-activated signaling pathway involved in heart process + 2
            endothelin receptor signaling pathway involved in heart process 0
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological process 13071
        regulation of cellular process 12556
          signal transduction 7010
            G protein-coupled receptor signaling pathway 2509
              G protein-coupled receptor signaling pathway involved in heart process 12
                G protein-coupled acetylcholine receptor signaling pathway involved in heart process + 0
                adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process + 8
                adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process + 1
                angiotensin-activated signaling pathway involved in heart process + 2
                endothelin receptor signaling pathway involved in heart process 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.