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ONTOLOGY REPORT - ANNOTATIONS


Term:planar cell polarity pathway involved in neural tube closure
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Accession:GO:0090179 term browser browse the term
Definition:The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure.


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planar cell polarity pathway involved in neural tube closure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 JBrowse link 7 126,774,010 126,914,085 RGD:1624291
RGD:1600115
G Dvl1 dishevelled segment polarity protein 1 JBrowse link 5 173,295,948 173,308,014 RGD:1624291
RGD:13792537
G Dvl2 dishevelled segment polarity protein 2 JBrowse link 10 56,609,810 56,619,269 RGD:1624291
RGD:13792537
G Dvl3 dishevelled segment polarity protein 3 JBrowse link 11 84,051,177 84,068,479 RGD:1624291
RGD:13792537
G Fzd1 frizzled class receptor 1 JBrowse link 4 26,470,864 26,475,262 RGD:1624291
RGD:1600115
G Fzd2 frizzled class receptor 2 JBrowse link 10 90,550,147 90,552,057 RGD:1624291
RGD:1600115
G Grhl3 grainyhead-like transcription factor 3 JBrowse link 5 153,893,039 153,925,045 RGD:1624291
RGD:1600115
G Ptk7 protein tyrosine kinase 7 JBrowse link 9 16,662,588 16,729,888 RGD:1624291
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1624291
RGD:1600115
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:1624291
RGD:1600115
G Sfrp5 secreted frizzled-related protein 5 JBrowse link 1 261,442,108 261,446,570 RGD:1624291
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
RGD:1600115
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
negative regulation of planar cell polarity pathway involved in neural tube closure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17967
    developmental process 6388
      anatomical structure formation involved in morphogenesis 1169
        tube formation 176
          tube closure 111
            neural tube closure 110
              planar cell polarity pathway involved in neural tube closure 14
                negative regulation of planar cell polarity pathway involved in neural tube closure 1
                regulation of planar cell polarity pathway involved in neural tube closure + 1
Path 2
Term Annotations click to browse term
  biological_process 17967
    developmental process 6388
      anatomical structure development 5991
        multicellular organism development 5486
          tube development 1156
            tube morphogenesis 891
              tube formation 176
                epithelial tube formation 161
                  embryonic epithelial tube formation 154
                    neural tube formation 132
                      primary neural tube formation 117
                        neural tube closure 110
                          establishment of planar polarity involved in neural tube closure 16
                            regulation of establishment of planar polarity involved in neural tube closure 15
                              planar cell polarity pathway involved in neural tube closure 14
                                negative regulation of planar cell polarity pathway involved in neural tube closure 1
                                regulation of planar cell polarity pathway involved in neural tube closure + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.