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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of release of cytochrome c from mitochondria
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Accession:GO:0090199 term browser browse the term
Definition:Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
Comment:The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly regulate this process.


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regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Plscr3 phospholipid scramblase 3 JBrowse link 10 56,452,632 56,458,390 RGD:1624291
RGD:1600115
negative regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:1624291
RGD:1600115
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5510006
G Avp arginine vasopressin JBrowse link 3 123,117,482 123,119,460 RGD:1624291
G Bcl2l2 Bcl2-like 2 JBrowse link 15 33,543,774 33,549,165 RGD:14394498
G Fxn frataxin JBrowse link 1 242,123,975 242,152,834 RGD:1624291
RGD:1600115
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:1624291
RGD:1600115
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:1624291
G Higd1a HIG1 hypoxia inducible domain family, member 1A JBrowse link 8 130,482,492 130,491,888 RGD:1624291
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:1624291
RGD:1600115
G Lmna lamin A/C JBrowse link 2 187,842,884 187,863,552 RGD:1624291
RGD:1600115
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:12738362
G Nol3 nucleolar protein 3 JBrowse link 19 37,232,567 37,236,668 RGD:10047155
RGD:1624291
G Opa1 OPA1, mitochondrial dynamin like GTPase JBrowse link 11 74,717,600 74,793,902 RGD:1624291
RGD:1600115
G Pam16 presequence translocase associated motor 16 JBrowse link 10 11,146,359 11,153,936 RGD:13462066
G Parl presenilin associated, rhomboid-like JBrowse link 11 84,517,368 84,544,463 RGD:1600115
RGD:1624291
G Ppif peptidylprolyl isomerase F JBrowse link 16 1,979,191 1,985,912 RGD:1624291
RGD:1600115
G Prelid1 PRELI domain containing 1 JBrowse link 17 9,834,245 9,837,285 RGD:1624291
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1600115
RGD:1624291
G Psmd10 proteasome 26S subunit, non-ATPase 10 JBrowse link X 112,323,188 112,328,642 RGD:1624291
RGD:1600115
G Triap1 TP53 regulated inhibitor of apoptosis 1 JBrowse link 12 46,987,404 46,989,906 RGD:1624291
positive regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AC130253.1 RGD:13792537
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:1624291
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:2317097
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1600115
RGD:1624291
G Bbc3 Bcl-2 binding component 3 JBrowse link 1 78,261,491 78,267,802 RGD:13792537
RGD:1624291
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:1624291
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:1624291
RGD:13792537
G Bik BCL2-interacting killer JBrowse link 7 124,390,924 124,410,449 RGD:1624291
G Bmf Bcl2 modifying factor JBrowse link 3 110,303,515 110,324,125 RGD:1624291
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:1624291
G Cideb cell death-inducing DFFA-like effector b JBrowse link 15 34,439,844 34,444,244 RGD:1624291
G Dnm1l dynamin 1-like JBrowse link 11 88,830,968 88,882,271 RGD:1624291
G Fam162a family with sequence similarity 162, member A JBrowse link 11 67,618,683 67,646,253 RGD:1624291
RGD:13792537
RGD:1600115
G Gper1 G protein-coupled estrogen receptor 1 JBrowse link 12 17,309,122 17,315,267 RGD:8553942
G Hrk harakiri, BCL2 interacting protein JBrowse link 12 44,008,879 44,029,211 RGD:1624291
G Mff mitochondrial fission factor JBrowse link 9 88,490,280 88,518,517 RGD:1624291
G Mllt11 MLLT11, transcription factor 7 cofactor JBrowse link 2 196,392,936 196,402,106 RGD:1624291
RGD:13792537
RGD:1600115
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:1624291
RGD:1600115
G Moap1 modulator of apoptosis 1 JBrowse link 6 126,620,597 126,622,532 RGD:1624291
G Pdcd5 programmed cell death 5 JBrowse link 1 91,173,473 91,178,801 RGD:1624291
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:1624291
G Pla2g6 phospholipase A2 group VI JBrowse link 7 120,519,479 120,559,716 RGD:6482750
G Plaur plasminogen activator, urokinase receptor JBrowse link 1 81,328,171 81,344,954 RGD:1624291
RGD:1600115
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:1624291
G Ppif peptidylprolyl isomerase F JBrowse link 16 1,979,191 1,985,912 RGD:1624291
RGD:1600115
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:1624291
G RGD1306484 similar to growth and transformation-dependent protein JBrowse link 10 37,582,678 37,583,232 RGD:13792537
G Tnfsf10 TNF superfamily member 10 JBrowse link 2 113,008,008 113,026,899 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Wdr35 WD repeat domain 35 JBrowse link 6 34,094,291 34,152,048 RGD:11553920

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    response to stimulus 10526
      regulation of response to stimulus 4066
        regulation of signal transduction 2973
          regulation of apoptotic signaling pathway 430
            regulation of release of cytochrome c from mitochondria 50
              negative regulation of release of cytochrome c from mitochondria 20
              positive regulation of release of cytochrome c from mitochondria 30
Path 2
Term Annotations click to browse term
  biological_process 19858
    cellular process 18617
      cellular component organization or biogenesis 6706
        cellular component organization 6456
          organelle organization 4029
            mitochondrion organization 534
              apoptotic mitochondrial changes 118
                release of cytochrome c from mitochondria 63
                  regulation of release of cytochrome c from mitochondria 50
                    negative regulation of release of cytochrome c from mitochondria 20
                    positive regulation of release of cytochrome c from mitochondria 30
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.