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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of release of cytochrome c from mitochondria
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Accession:GO:0090200 term browser browse the term
Definition:Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
Comment:The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and positively regulate this process.


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positive regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC130253.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr10:37,582,706...37,583,167 JBrowse link
G Bad BCL2-associated agonist of cell death ISO (PMID:17289999) RGD PMID:17289999 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bak1 BCL2-antagonist/killer 1 IMP RGD PMID:12485416 RGD:2317097 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator IEA
ISO
ISS
GO_REF:0000107
(PMID:14963330), (PMID:21262771)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:14963330, PMID:21262771 GO_REF:0000024, GO_REF:0000107 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 IBA
ISO
PMID:21873635
UniProtKB:P70444 (PMID:21041309)
RGD PMID:21041309, PMID:21873635 RGD:13792537 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2l11 BCL2 like 11 ISO UniProtKB:P70444 (PMID:17289999), (PMID:21041309) RGD PMID:17289999, PMID:21041309 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bid BH3 interacting domain death agonist ISO
IBA
UniProtKB:O08734|UniProtKB:P70444 (MGI:MGI:5009197|PMID:10950869), (MGI:MGI:5009775|PMID:21041309)
PMID:21873635
UniProtKB:P70444 (PMID:17289999), (PMID:21041309), (PMID:21262771)
RGD PMID:10950869, PMID:17289999, PMID:21041309, PMID:21262771, PMID:21873635 MGI:MGI:5009197, MGI:MGI:5009775, RGD:13792537 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Bik BCL2-interacting killer ISO (PMID:21041309) RGD PMID:21041309 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447
JBrowse link
G Bmf Bcl2 modifying factor ISO UniProtKB:P70444 (MGI:MGI:5009775|PMID:21041309) RGD PMID:21041309 MGI:MGI:5009775 NCBI chr 3:110,303,515...110,324,125
Ensembl chr 3:110,306,067...110,324,084
JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO (PMID:20436456) RGD PMID:20436456 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Cideb cell death-inducing DFFA-like effector b ISO (PMID:12595532) RGD PMID:12595532 NCBI chr15:34,439,844...34,444,244
Ensembl chr15:34,439,876...34,444,244
JBrowse link
G Dnm1l dynamin 1-like ISO (PMID:21149567) RGD PMID:21149567 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Fam162a family with sequence similarity 162, member A ISO
IBA
ISS
(PMID:15082785)
PMID:21873635
(MGI:MGI:5319617|PMID:15082785)
GO_REF:0000024
RGD
UniProt
PMID:15082785, PMID:21873635 GO_REF:0000024, MGI:MGI:5319617, RGD:13792537 NCBI chr11:67,618,683...67,646,253
Ensembl chr11:67,618,625...67,646,253
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 IDA PMID:23907461 UniProt PMID:23907461 RGD:8553942 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Hrk harakiri, BCL2 interacting protein ISO (PMID:21041309) RGD PMID:21041309 NCBI chr12:44,008,879...44,029,211 JBrowse link
G Mff mitochondrial fission factor ISO (PMID:21149567) RGD PMID:21149567 NCBI chr 9:88,490,280...88,518,517
Ensembl chr 9:88,493,593...88,517,827
JBrowse link
G Mllt11 MLLT11, transcription factor 7 cofactor ISO
IBA
ISS
(PMID:18852119)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:18852119, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 2:196,392,936...196,402,106
Ensembl chr 2:196,392,938...196,402,106
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO
IEA
(PMID:22984561)
GO_REF:0000107
RGD
Ensembl
PMID:22984561 GO_REF:0000107 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Moap1 modulator of apoptosis 1 ISO (PMID:16199525) RGD PMID:16199525 NCBI chr 6:126,620,597...126,622,532
Ensembl chr 6:126,620,602...126,622,532
JBrowse link
G Pdcd5 programmed cell death 5 ISO (PMID:16374546) RGD PMID:16374546 NCBI chr 1:91,173,473...91,178,801
Ensembl chr 1:91,173,473...91,178,801
Ensembl chr 1:91,173,473...91,178,801
JBrowse link
G Pink1 PTEN induced kinase 1 ISO (PMID:19880420) RGD PMID:19880420 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Pla2g6 phospholipase A2 group VI IDA RGD PMID:18936091 RGD:6482750 NCBI chr 7:120,519,479...120,559,716
Ensembl chr 7:120,519,467...120,559,347
JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO
IEA
(PMID:22984561)
GO_REF:0000107
RGD
Ensembl
PMID:22984561 GO_REF:0000107 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 ISO (PMID:14500711), (PMID:14699081), (PMID:15705586), (PMID:17289999) RGD PMID:14500711, PMID:14699081, PMID:15705586, PMID:17289999 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Ppif peptidylprolyl isomerase F ISO
ISS
(MGI:MGI:3575990|PMID:15800627)
GO_REF:0000024
RGD
UniProt
PMID:15800627 GO_REF:0000024, MGI:MGI:3575990 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Pycard PYD and CARD domain containing ISO (PMID:14730312) RGD PMID:14730312 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G RGD1306484 similar to growth and transformation-dependent protein IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:37,582,678...37,583,232 JBrowse link
G Tnfsf10 TNF superfamily member 10 ISO (PMID:22266862) RGD PMID:22266862 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tp53 tumor protein p53 ISO (PMID:14963330) RGD PMID:14963330 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Wdr35 WD repeat domain 35 IMP RGD PMID:23289926 RGD:11553920 NCBI chr 6:34,094,291...34,152,048
Ensembl chr 6:34,094,306...34,151,622
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      signal transduction 7011
        apoptotic signaling pathway 630
          release of cytochrome c from mitochondria 64
            positive regulation of release of cytochrome c from mitochondria 30
Path 2
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      cellular component organization or biogenesis 6789
        cellular component organization 6534
          organelle organization 4101
            mitochondrion organization 547
              apoptotic mitochondrial changes 120
                release of cytochrome c from mitochondria 64
                  regulation of release of cytochrome c from mitochondria 51
                    positive regulation of release of cytochrome c from mitochondria 30
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.