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Term:negative regulation of release of cytochrome c from mitochondria
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Accession:GO:0090201 term browser browse the term
Definition:Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
Comment:The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and negatively regulate this process.

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negative regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:1624291
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5510006
G Avp arginine vasopressin JBrowse link 3 123,117,482 123,119,460 RGD:1624291
G Bcl2l2 Bcl2-like 2 JBrowse link 15 33,543,774 33,549,165 RGD:14394498
G Fxn frataxin JBrowse link 1 242,123,975 242,152,834 RGD:1624291
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:1624291
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:1624291
G Higd1a HIG1 hypoxia inducible domain family, member 1A JBrowse link 8 130,482,492 130,491,888 RGD:1624291
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:1624291
G Lmna lamin A/C JBrowse link 2 187,842,884 187,863,552 RGD:1624291
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:12738362
G Nol3 nucleolar protein 3 JBrowse link 19 37,232,567 37,236,668 RGD:10047155
G Opa1 OPA1, mitochondrial dynamin like GTPase JBrowse link 11 74,717,600 74,793,902 RGD:1624291
G Pam16 presequence translocase associated motor 16 JBrowse link 10 11,146,359 11,153,936 RGD:13462066
G Parl presenilin associated, rhomboid-like JBrowse link 11 84,517,368 84,544,463 RGD:1600115
G Ppif peptidylprolyl isomerase F JBrowse link 16 1,979,191 1,985,912 RGD:1624291
G Prelid1 PRELI domain containing 1 JBrowse link 17 9,834,245 9,837,285 RGD:1624291
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1600115
G Psmd10 proteasome 26S subunit, non-ATPase 10 JBrowse link X 112,323,188 112,328,642 RGD:1624291
G Triap1 TP53 regulated inhibitor of apoptosis 1 JBrowse link 12 46,987,404 46,989,906 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19678
    negative regulation of biological process 5607
      negative regulation of signaling 1395
        negative regulation of signal transduction 1232
          negative regulation of apoptotic signaling pathway 239
            negative regulation of release of cytochrome c from mitochondria 20
Path 2
Term Annotations click to browse term
  biological_process 19678
    cellular process 18452
      cellular component organization or biogenesis 6667
        cellular component organization 6427
          organelle organization 4013
            mitochondrion organization 532
              apoptotic mitochondrial changes 117
                release of cytochrome c from mitochondria 62
                  regulation of release of cytochrome c from mitochondria 49
                    negative regulation of release of cytochrome c from mitochondria 20
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.