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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of spindle checkpoint
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Accession:GO:0090231 term browser browse the term
Definition:Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
Comment:Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).


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deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 ISO (PMID:22581055) CAFA PMID:22581055 NCBI chrNW_004955541:2,683,030...2,687,883
Ensembl chrNW_004955541:2,683,408...2,687,102
JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 ISO (PMID:19229290) UniProtKB PMID:19229290 NCBI chrNW_004955620:46,535...82,595
Ensembl chrNW_004955620:46,556...82,595
JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease ISO (PMID:23108668) UniProtKB PMID:23108668 NCBI chrNW_004955469:552,850...590,792
Ensembl chrNW_004955469:552,677...592,137
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 ISO (MGI:MGI:4839685|PMID:20870947)
(PMID:20870947)
UniProtKB PMID:20870947 MGI:MGI:4839685 NCBI chrNW_004955428:20,421,718...20,443,394
Ensembl chrNW_004955428:20,421,723...20,430,307
JBrowse link
G Ndc80 NDC80 kinetochore complex component ISO (PMID:25743205) UniProtKB PMID:25743205 NCBI chrNW_004955402:7,692,009...7,728,876
Ensembl chrNW_004955402:7,691,937...7,729,690
JBrowse link
G Pcid2 PCI domain containing 2 ISO (MGI:MGI:4839685|PMID:20870947)
(PMID:20870947)
UniProtKB PMID:20870947 MGI:MGI:4839685 NCBI chrNW_004955404:618,092...639,424
Ensembl chrNW_004955404:618,092...639,704
JBrowse link
G Tpr translocated promoter region, nuclear basket protein ISO (PMID:18981471), (PMID:19273613) UniProt PMID:18981471, PMID:19273613 NCBI chrNW_004955406:24,742,525...24,805,989
Ensembl chrNW_004955406:24,742,525...24,805,989
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 ISO (PMID:23108668) UniProtKB PMID:23108668 NCBI chrNW_004955538:2,499,297...2,511,898
Ensembl chrNW_004955538:2,501,607...2,509,778
JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc15 anaphase promoting complex subunit 15 ISO (PMID:21926987) UniProtKB PMID:21926987 NCBI chrNW_004955414:19,218,727...19,222,138
Ensembl chrNW_004955414:19,218,727...19,222,138
JBrowse link
G Ccnb1 cyclin B1 ISO (PMID:18195732) BHF-UCL PMID:18195732 NCBI chrNW_004955446:140,661...149,500
Ensembl chrNW_004955446:140,093...149,500
JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 ISO (PMID:19282672) UniProtKB PMID:19282672 NCBI chrNW_004955419:7,412,177...7,606,883
Ensembl chrNW_004955419:7,412,331...7,610,353
JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 ISO (PMID:17724024) MGI PMID:17724024 NCBI chrNW_004955493:3,440,832...3,499,658
Ensembl chrNW_004955493:3,431,578...3,502,066
JBrowse link
G Usp44 ubiquitin specific peptidase 44 ISO (MGI:MGI:5448515|PMID:21853124) UniProtKB PMID:21853124 MGI:MGI:5448515 NCBI chrNW_004955405:31,977,045...32,006,733
Ensembl chrNW_004955405:31,977,602...32,006,810
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11892
    cellular process 11094
      cell cycle checkpoint 128
        regulation of cell cycle checkpoint 30
          regulation of spindle checkpoint 13
            negative regulation of spindle checkpoint + 1
            positive regulation of spindle checkpoint + 7
            regulation of meiosis I spindle assembly checkpoint + 0
            regulation of mitotic spindle checkpoint + 13
Path 2
Term Annotations click to browse term
  biological_process 11892
    biological regulation 8722
      regulation of biological process 8267
        regulation of cellular process 7844
          negative regulation of cellular process 4219
            negative regulation of cell cycle 368
              cell cycle checkpoint 128
                spindle checkpoint 25
                  regulation of spindle checkpoint 13
                    negative regulation of spindle checkpoint + 1
                    positive regulation of spindle checkpoint + 7
                    regulation of meiosis I spindle assembly checkpoint + 0
                    regulation of mitotic spindle checkpoint + 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.