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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of spindle checkpoint
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Accession:GO:0090231 term browser browse the term
Definition:Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
Comment:Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).


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deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDT1 chromatin licensing and DNA replication factor 1 ISO (PMID:22581055) CAFA PMID:22581055 NCBI chr 5:64,566,035...64,570,361
Ensembl chr 5:64,566,043...64,570,748
JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DYNC1LI1 dynein cytoplasmic 1 light intermediate chain 1 IEA Ensembl GO_REF:0000107 NCBI chr23:12,235,539...12,283,851
Ensembl chr23:12,235,104...12,277,031
JBrowse link
G GEN1 GEN1 Holliday junction 5' flap endonuclease IEA Ensembl GO_REF:0000107 NCBI chr17:13,201,540...13,233,028
Ensembl chr17:13,201,777...13,232,120
JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 ISO (MGI:MGI:4839685|PMID:20870947)
(PMID:20870947)
UniProtKB PMID:20870947 MGI:MGI:4839685 NCBI chr18:55,653,677...55,661,017 JBrowse link
G NDC80 NDC80 kinetochore complex component IEA Ensembl GO_REF:0000107 NCBI chr 7:69,268,218...69,317,126
Ensembl chr 7:69,268,242...69,317,072
JBrowse link
G PCID2 PCI domain containing 2 IEA Ensembl GO_REF:0000107 NCBI chr22:60,602,440...60,623,811
Ensembl chr22:60,602,888...60,623,719
JBrowse link
G TPR translocated promoter region, nuclear basket protein IEA Ensembl GO_REF:0000107 NCBI chr 7:19,376,951...19,442,368
Ensembl chr 7:19,376,975...19,442,303
JBrowse link
G XRCC3 X-ray repair cross complementing 3 IEA Ensembl GO_REF:0000107 NCBI chr 8:71,441,732...71,452,922
Ensembl chr 8:71,442,429...71,449,408
JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANAPC15 anaphase promoting complex subunit 15 IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr21:25,971,680...25,975,556
Ensembl chr21:25,972,458...25,975,558
JBrowse link
G CCNB1 cyclin B1 ISO (PMID:18195732) BHF-UCL PMID:18195732 NCBI chr 2:54,256,957...54,264,749 JBrowse link
G CDK5RAP2 CDK5 regulatory subunit associated protein 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr11:73,548,003...73,693,044
Ensembl chr11:73,548,038...73,690,199
JBrowse link
G LCMT1 leucine carboxyl methyltransferase 1 IEA Ensembl GO_REF:0000107 NCBI chr 6:21,026,125...21,066,884
Ensembl chr 6:21,026,186...21,066,876
JBrowse link
G USP44 ubiquitin specific peptidase 44 IEA Ensembl GO_REF:0000107 NCBI chr15:35,401,486...35,454,351
Ensembl chr15:35,402,207...35,414,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16187
    cellular process 15465
      cell cycle checkpoint 159
        regulation of cell cycle checkpoint 30
          regulation of spindle checkpoint 13
            negative regulation of spindle checkpoint + 1
            positive regulation of spindle checkpoint + 7
            regulation of meiosis I spindle assembly checkpoint + 0
            regulation of mitotic spindle checkpoint + 13
Path 2
Term Annotations click to browse term
  biological_process 16187
    biological regulation 11555
      regulation of biological process 10957
        regulation of cellular process 10498
          negative regulation of cellular process 4876
            negative regulation of cell cycle 429
              cell cycle checkpoint 159
                spindle checkpoint 35
                  regulation of spindle checkpoint 13
                    negative regulation of spindle checkpoint + 1
                    positive regulation of spindle checkpoint + 7
                    regulation of meiosis I spindle assembly checkpoint + 0
                    regulation of mitotic spindle checkpoint + 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.