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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of spindle checkpoint
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Accession:GO:0090231 term browser browse the term
Definition:Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
Comment:Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).


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deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDT1 chromatin licensing and DNA replication factor 1 IMP (PMID:22581055) CAFA PMID:22581055 NCBI chr16:88,803,789...88,809,258
Ensembl chr16:88,803,789...88,809,258
JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DYNC1LI1 dynein cytoplasmic 1 light intermediate chain 1 IMP (PMID:19229290) UniProtKB PMID:19229290 NCBI chr 3:32,525,974...32,570,858
Ensembl chr 3:32,525,974...32,570,858
JBrowse link
G GEN1 GEN1 Holliday junction 5' flap endonuclease IMP (PMID:23108668) UniProtKB PMID:23108668 NCBI chr 2:17,753,687...17,788,946
Ensembl chr 2:17,753,858...17,788,946
JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 IMP (PMID:20870947) UniProtKB PMID:20870947 NCBI chr 4:120,055,623...120,066,848
Ensembl chr 4:120,055,623...120,066,858
JBrowse link
G NDC80 NDC80 kinetochore complex component IMP (PMID:25743205) UniProtKB PMID:25743205 NCBI chr18:2,571,557...2,616,635
Ensembl chr18:2,571,557...2,616,635
JBrowse link
G PCID2 PCI domain containing 2 IMP (PMID:20870947) UniProtKB PMID:20870947 NCBI chr13:113,165,002...113,209,467
Ensembl chr13:113,177,536...113,208,715
JBrowse link
G TPR translocated promoter region, nuclear basket protein IMP (PMID:18981471), (PMID:19273613) UniProt PMID:18981471, PMID:19273613 NCBI chr 1:186,311,652...186,375,253
Ensembl chr 1:186,311,652...186,375,693
JBrowse link
G XRCC3 X-ray repair cross complementing 3 IMP (PMID:23108668) UniProtKB PMID:23108668 NCBI chr14:103,697,611...103,715,486
Ensembl chr14:103,697,609...103,715,504
JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANAPC15 anaphase promoting complex subunit 15 IEA
IBA
IMP
(PMID:21873635)
(PMID:21926987)
InterPro
GO_Central
UniProtKB
PMID:21873635, PMID:21926987 GO_REF:0000002 NCBI chr11:72,106,372...72,112,780
Ensembl chr11:72,106,378...72,112,780
JBrowse link
G CCNB1 cyclin B1 IMP (PMID:18195732) BHF-UCL PMID:18195732 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CDK5RAP2 CDK5 regulatory subunit associated protein 2 IDA
IBA
(PMID:19282672)
(PMID:21873635)
UniProtKB
GO_Central
PMID:19282672, PMID:21873635 NCBI chr 9:120,388,875...120,580,167
Ensembl chr 9:120,388,869...120,580,170
JBrowse link
G DUSP1 dual specificity phosphatase 1 ISS UniProtKB GO_REF:0000024 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
JBrowse link
G LCMT1 leucine carboxyl methyltransferase 1 IMP (PMID:17724024) MGI PMID:17724024 NCBI chr16:25,111,702...25,178,231
Ensembl chr16:25,111,731...25,178,231
JBrowse link
G USP44 ubiquitin specific peptidase 44 ISS UniProtKB GO_REF:0000024 NCBI chr12:95,516,560...95,551,529
Ensembl chr12:95,516,560...95,551,476
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18670
    cellular process 17687
      cell cycle checkpoint 209
        regulation of cell cycle checkpoint 32
          regulation of spindle checkpoint 14
            negative regulation of spindle checkpoint + 1
            positive regulation of spindle checkpoint + 7
            regulation of meiosis I spindle assembly checkpoint + 0
            regulation of mitotic spindle checkpoint + 14
Path 2
Term Annotations click to browse term
  biological_process 18670
    biological regulation 13309
      regulation of biological process 12641
        regulation of cellular process 12035
          negative regulation of cellular process 5521
            negative regulation of cell cycle 633
              cell cycle checkpoint 209
                spindle checkpoint 38
                  regulation of spindle checkpoint 14
                    negative regulation of spindle checkpoint + 1
                    positive regulation of spindle checkpoint + 7
                    regulation of meiosis I spindle assembly checkpoint + 0
                    regulation of mitotic spindle checkpoint + 14
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.