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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of spindle checkpoint
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Accession:GO:0090231 term browser browse the term
Definition:Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
Comment:Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).


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deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 8:122,568,015...122,573,130
Ensembl chr 8:122,568,015...122,573,554
JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 9:114,688,831...114,723,788
Ensembl chr 9:114,688,790...114,724,302
JBrowse link
G Gen1 GEN1, Holliday junction 5' flap endonuclease ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr12:11,238,928...11,266,029
Ensembl chr12:11,238,920...11,265,801
JBrowse link
G Mad2l1 MAD2 mitotic arrest deficient-like 1 IMP
ISO
(MGI:MGI:4839685|PMID:20870947) UniProtKB
MGI
PMID:20870947 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:4839685 NCBI chr 6:66,535,221...66,541,107
Ensembl chr 6:66,535,390...66,547,220
JBrowse link
G Ndc80 NDC80 kinetochore complex component ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr17:71,496,100...71,526,857
Ensembl chr17:71,496,100...71,526,857
JBrowse link
G Pcid2 PCI domain containing 2 IMP
ISO
(MGI:MGI:4839685|PMID:20870947) UniProtKB
MGI
PMID:20870947 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:4839685 NCBI chr 8:13,075,476...13,105,343
Ensembl chr 8:13,077,189...13,105,459
JBrowse link
G Tpr translocated promoter region, nuclear basket protein ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 1:150,392,802...150,449,935
Ensembl chr 1:150,392,838...150,449,935
JBrowse link
G Xrcc3 X-ray repair complementing defective repair in Chinese hamster cells 3 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr12:111,803,192...111,813,893
Ensembl chr12:111,803,192...111,813,873
JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc15 anaphase promoting complex C subunit 15 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 7:101,881,300...101,901,849
Ensembl chr 7:101,863,715...101,901,849
JBrowse link
G Ccnb1 cyclin B1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570
JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 4:70,216,855...70,410,435
Ensembl chr 4:70,216,856...70,410,443
JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 ISO MGI GO_REF:0000008, MGI:MGI:2154458 NCBI chr 7:123,377,803...123,430,358
Ensembl chr 7:123,369,784...123,430,358
JBrowse link
G Usp44 ubiquitin specific peptidase 44 IDA (MGI:MGI:5448515|PMID:21853124) UniProtKB PMID:21853124 MGI:MGI:5448515 NCBI chr10:93,819,969...93,859,425
Ensembl chr10:93,831,555...93,858,088
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23392
    cellular process 17416
      cell cycle checkpoint 162
        regulation of cell cycle checkpoint 31
          regulation of spindle checkpoint 13
            negative regulation of spindle checkpoint + 1
            positive regulation of spindle checkpoint + 7
            regulation of meiosis I spindle assembly checkpoint + 0
            regulation of mitotic spindle checkpoint + 13
Path 2
Term Annotations click to browse term
  biological_process 23392
    biological regulation 13113
      regulation of biological process 12479
        regulation of cellular process 11921
          negative regulation of cellular process 5089
            negative regulation of cell cycle 455
              cell cycle checkpoint 162
                spindle checkpoint 35
                  regulation of spindle checkpoint 13
                    negative regulation of spindle checkpoint + 1
                    positive regulation of spindle checkpoint + 7
                    regulation of meiosis I spindle assembly checkpoint + 0
                    regulation of mitotic spindle checkpoint + 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.