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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of spindle checkpoint
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Accession:GO:0090231 term browser browse the term
Definition:Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
Comment:Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).


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deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDT1 chromatin licensing and DNA replication factor 1 ISO (PMID:22581055) CAFA PMID:22581055 NCBI chr 6:893,377...897,706 JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DYNC1LI1 dynein cytoplasmic 1 light intermediate chain 1 IEA Ensembl GO_REF:0000107 NCBI chr13:18,507,710...18,558,057
Ensembl chr13:18,506,194...18,558,007
JBrowse link
G GEN1 GEN1 Holliday junction 5' flap endonuclease IEA Ensembl GO_REF:0000107 NCBI chr 3:120,067,792...120,097,305
Ensembl chr 3:120,065,973...120,097,069
JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 IEA Ensembl GO_REF:0000107 NCBI chr 8:103,927,358...103,936,669
Ensembl chr 8:103,927,353...103,936,664
JBrowse link
G NDC80 NDC80 kinetochore complex component IEA Ensembl GO_REF:0000107 NCBI chr 6:104,000,794...104,055,785
Ensembl chr 6:103,998,698...104,055,762
JBrowse link
G PCID2 PCI domain containing 2 IEA Ensembl GO_REF:0000107 NCBI chr11:78,541,278...78,556,784
Ensembl chr11:78,541,318...78,556,733
JBrowse link
G TPR translocated promoter region, nuclear basket protein IEA Ensembl GO_REF:0000107 NCBI chr 9:127,481,678...127,540,393
Ensembl chr 9:127,481,684...127,540,790
JBrowse link
G XRCC3 X-ray repair cross complementing 3 IEA Ensembl GO_REF:0000107
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANAPC15 anaphase promoting complex subunit 15 IEA InterPro GO_REF:0000002 NCBI chr 9:6,685,934...6,689,913
Ensembl chr 9:6,685,936...6,689,256
JBrowse link
G CCNB1 cyclin B1 IEA Ensembl GO_REF:0000107 NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,381
JBrowse link
G CDK5RAP2 CDK5 regulatory subunit associated protein 2 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 1:260,465,809...260,648,070
Ensembl chr 1:260,467,159...260,635,443
JBrowse link
G LCMT1 leucine carboxyl methyltransferase 1 ISO (PMID:17724024) MGI PMID:17724024 NCBI chr 3:21,548,349...21,593,667 JBrowse link
G USP44 ubiquitin specific peptidase 44 IEA Ensembl GO_REF:0000107 NCBI chr 5:87,864,410...87,890,913
Ensembl chr 5:87,875,851...87,889,684
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16545
    cellular process 15777
      cell cycle checkpoint 158
        regulation of cell cycle checkpoint 30
          regulation of spindle checkpoint 13
            negative regulation of spindle checkpoint + 1
            positive regulation of spindle checkpoint + 7
            regulation of meiosis I spindle assembly checkpoint + 0
            regulation of mitotic spindle checkpoint + 13
Path 2
Term Annotations click to browse term
  biological_process 16545
    biological regulation 12011
      regulation of biological process 11420
        regulation of cellular process 10969
          negative regulation of cellular process 4868
            negative regulation of cell cycle 427
              cell cycle checkpoint 158
                spindle checkpoint 34
                  regulation of spindle checkpoint 13
                    negative regulation of spindle checkpoint + 1
                    positive regulation of spindle checkpoint + 7
                    regulation of meiosis I spindle assembly checkpoint + 0
                    regulation of mitotic spindle checkpoint + 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.