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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of spindle checkpoint
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Accession:GO:0090231 term browser browse the term
Definition:Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
Comment:Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).


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deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 ISO (PMID:22581055) CAFA PMID:22581055 NCBI chrNW_004936641:916,695...925,411 JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 ISO (PMID:19229290) UniProtKB PMID:19229290 NCBI chrNW_004936473:23,011,888...23,042,497 JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease ISO (PMID:23108668) UniProtKB PMID:23108668 NCBI chrNW_004936493:13,157,114...13,182,797 JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 ISO (MGI:MGI:4839685|PMID:20870947)
(PMID:20870947)
UniProtKB PMID:20870947 MGI:MGI:4839685 NCBI chrNW_004936662:92,421...98,531 JBrowse link
G Ndc80 NDC80 kinetochore complex component ISO (PMID:25743205) UniProtKB PMID:25743205 NCBI chrNW_004936672:1,872,205...1,910,956 JBrowse link
G Pcid2 PCI domain containing 2 ISO (PMID:20870947)
(MGI:MGI:4839685|PMID:20870947)
UniProtKB PMID:20870947 MGI:MGI:4839685 NCBI chrNW_004936472:440,440...464,116 JBrowse link
G Tpr translocated promoter region, nuclear basket protein ISO (PMID:18981471), (PMID:19273613) UniProt PMID:18981471, PMID:19273613 NCBI chrNW_004936481:4,050,693...4,111,682 JBrowse link
G Xrcc3 X-ray repair cross complementing 3 ISO (PMID:23108668) UniProtKB PMID:23108668 NCBI chrNW_004936621:1,462,441...1,474,937 JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc15 anaphase promoting complex subunit 15 ISO (PMID:21926987) UniProtKB PMID:21926987 NCBI chrNW_004936498:1,460,795...1,468,363 JBrowse link
G Ccnb1 cyclin B1 ISO (PMID:18195732) BHF-UCL PMID:18195732 NCBI chrNW_004936480:400,287...407,677 JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 ISO (PMID:19282672) UniProtKB PMID:19282672 NCBI chrNW_004936487:8,900,375...9,081,547 JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 ISO (PMID:17724024) MGI PMID:17724024 NCBI chrNW_004936501:9,354,607...9,397,675 JBrowse link
G Usp44 ubiquitin specific peptidase 44 ISO (MGI:MGI:5448515|PMID:21853124) UniProtKB PMID:21853124 MGI:MGI:5448515 NCBI chrNW_004936507:11,663,069...11,692,174 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11998
    cellular process 11174
      cell cycle checkpoint 128
        regulation of cell cycle checkpoint 30
          regulation of spindle checkpoint 13
            negative regulation of spindle checkpoint + 1
            positive regulation of spindle checkpoint + 7
            regulation of meiosis I spindle assembly checkpoint + 0
            regulation of mitotic spindle checkpoint + 13
Path 2
Term Annotations click to browse term
  biological_process 11998
    biological regulation 8793
      regulation of biological process 8336
        regulation of cellular process 7912
          negative regulation of cellular process 4248
            negative regulation of cell cycle 372
              cell cycle checkpoint 128
                spindle checkpoint 26
                  regulation of spindle checkpoint 13
                    negative regulation of spindle checkpoint + 1
                    positive regulation of spindle checkpoint + 7
                    regulation of meiosis I spindle assembly checkpoint + 0
                    regulation of mitotic spindle checkpoint + 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.