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ONTOLOGY REPORT - ANNOTATIONS


Term:cellular senescence
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Accession:GO:0090398 term browser browse the term
Definition:A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.


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cellular senescence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calr calreticulin ISO ENSEMBL_GeneID:ENSG00000124762 (PMID:14726956)
(MGI:MGI:3813434|PMID:14726956)
RGD PMID:14726956 MGI:MGI:3813434 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Cav1 caveolin 1 IMP RGD PMID:23941874 RGD:9588563 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO (PMID:15149599), (PMID:17553787) RGD PMID:15149599, PMID:17553787 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO (MGI:MGI:5299398|PMID:21911473), (MGI:MGI:5449665|PMID:22729085)
(PMID:14966292), (PMID:16243918)
RGD PMID:14966292, PMID:16243918, PMID:21911473, PMID:22729085 MGI:MGI:5299398, MGI:MGI:5449665 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B IEA
ISO
GO_REF:0000107
(PMID:17553787)
Ensembl
RGD
PMID:17553787 GO_REF:0000107 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
JBrowse link
G Ecrg4 ECRG4 augurin precursor ISO
IBA
(MGI:MGI:4454240|PMID:20404145)
PMID:21873635
RGD PMID:20404145, PMID:21873635 MGI:MGI:4454240, RGD:13792537 NCBI chr 9:50,526,811...50,548,056
Ensembl chr 9:50,526,811...50,548,046
JBrowse link
G H2ax H2A.X variant histone IEP RGD PMID:19946210 RGD:8693719 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hras HRas proto-oncogene, GTPase ISO
IBA
IEP
(PMID:9054499)
PMID:21873635
RGD PMID:9054499, PMID:21873635, PMID:17706954 RGD:13792537, RGD:11060281 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Id2 inhibitor of DNA binding 2 ISO
ISS
(MGI:MGI:4412240|PMID:18474814)
GO_REF:0000024
RGD
UniProt
PMID:18474814 GO_REF:0000024, MGI:MGI:4412240 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Igf1r insulin-like growth factor 1 receptor IEP RGD PMID:19862643 RGD:10045872 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Kat6a lysine acetyltransferase 6A ISO
IEA
ISS
(PMID:23431171)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:23431171 GO_REF:0000024, GO_REF:0000107 NCBI chr16:73,942,669...74,020,750
Ensembl chr16:73,943,455...74,023,005
JBrowse link
G Lmna lamin A/C IEP RGD PMID:20362703 RGD:12791030 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 ISO
IEA
(PMID:9765203)
GO_REF:0000107
RGD
Ensembl
PMID:9765203 GO_REF:0000107 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase ISO
ISS
(PMID:17589526)
GO_REF:0000024
RGD
UniProt
PMID:17589526 GO_REF:0000024 NCBI chr 7:99,677,295...99,900,765
Ensembl chr 7:99,677,290...99,900,764
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase ISO
ISS
(PMID:17545159)
GO_REF:0000024
RGD
ParkinsonsUK-UCL
PMID:17545159 GO_REF:0000024 NCBI chr11:74,717,600...74,793,902
Ensembl chr11:74,720,254...74,793,803
JBrowse link
G Pml PML nuclear body scaffold ISO (PMID:22002537), (PMID:22117195), (PMID:23431171) RGD PMID:22002537, PMID:22117195, PMID:23431171 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Prkcd protein kinase C, delta ISO
IEA
(PMID:15282327)
GO_REF:0000107
RGD
Ensembl
PMID:15282327 GO_REF:0000107 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prmt6 protein arginine methyltransferase 6 ISO (MGI:MGI:5504576|PMID:22904064) RGD PMID:22904064 MGI:MGI:5504576 NCBI chr 2:213,173,403...213,180,721
Ensembl chr 2:213,173,403...213,178,632
Ensembl chr 2:213,173,403...213,178,632
JBrowse link
G Smc5 structural maintenance of chromosomes 5 ISO (PMID:17589526) RGD PMID:17589526 NCBI chr 1:240,977,898...241,046,273
Ensembl chr 1:240,977,898...241,046,256
JBrowse link
G Smc6 structural maintenance of chromosomes 6 ISO (PMID:17589526) RGD PMID:17589526 NCBI chr 6:36,941,233...36,995,920
Ensembl chr 6:36,941,233...36,995,138
JBrowse link
G Srf serum response factor ISO (PMID:15282327) RGD PMID:15282327 NCBI chr 9:16,737,637...16,747,226
Ensembl chr 9:16,737,642...16,747,225
JBrowse link
G Tbx2 T-box transcription factor 2 ISO (PMID:22002537) RGD PMID:22002537 NCBI chr10:73,278,932...73,290,764
Ensembl chr10:73,279,119...73,289,921
JBrowse link
G Tbx3 T-box transcription factor 3 ISO
ISS
(PMID:22002537)
GO_REF:0000024
RGD
UniProt
PMID:22002537 GO_REF:0000024 NCBI chr12:42,479,518...42,494,588
Ensembl chr12:42,480,560...42,492,526
JBrowse link
negative regulation of cellular senescence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase ISO MGI:MGI:104738 (MGI:MGI:5449665|PMID:22729085) RGD PMID:22729085 MGI:MGI:5449665 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Akt3 AKT serine/threonine kinase 3 ISO
IEA
(PMID:25323119)
GO_REF:0000107
RGD
Ensembl
PMID:25323119 GO_REF:0000107 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913
JBrowse link
G Bcl2l12 BCL2 like 12 ISO (MGI:MGI:4834958|PMID:20837658) RGD PMID:20837658 MGI:MGI:4834958 NCBI chr 1:100,984,550...100,993,269
Ensembl chr 1:100,984,550...100,993,269
JBrowse link
G Bcl6 BCL6, transcription repressor ISO MGI:MGI:2158436 (MGI:MGI:5469797|PMID:23209284) RGD PMID:23209284 MGI:MGI:5469797 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Cdk6 cyclin-dependent kinase 6 ISO (PMID:17420273) RGD PMID:17420273 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Fbxo5 F-box protein 5 ISO (PMID:17875940) RGD PMID:17875940 NCBI chr 1:42,461,277...42,467,646
Ensembl chr 1:42,461,291...42,467,586
JBrowse link
G Hmga2 high mobility group AT-hook 2 ISO (MGI:MGI:5582375|PMID:23072816) RGD PMID:23072816 MGI:MGI:5582375 NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408
JBrowse link
G LOC100912427 nuclease-sensitive element-binding protein 1-like ISO (MGI:MGI:6158172|PMID:29712925) RGD PMID:29712925 MGI:MGI:6158172 NCBI chr 1:186,635,408...186,641,503
Ensembl chr 1:186,640,425...186,641,393
JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 ISO (PMID:28640956) RGD PMID:28640956 NCBI chr10:94,280,703...94,349,372
Ensembl chr10:94,280,703...94,349,368
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase IDA RGD PMID:28125705 RGD:13781884 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Plk2 polo-like kinase 2 ISO (MGI:MGI:6120300|PMID:27908889) RGD PMID:27908889 MGI:MGI:6120300 NCBI chr 2:41,911,143...41,916,901
Ensembl chr 2:41,911,131...41,916,901
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit IMP RGD PMID:22981234 RGD:8696027 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 ISO (PMID:28595801) RGD PMID:28595801 NCBI chr 3:153,263,692...153,321,351
Ensembl chr 3:153,263,692...153,321,352
JBrowse link
G Sirt1 sirtuin 1 ISO
IEA
(PMID:20203304), (PMID:20424141)
GO_REF:0000107
RGD
Ensembl
PMID:20203304, PMID:20424141 GO_REF:0000107 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc30a10 solute carrier family 30, member 10 ISO (PMID:22427991) RGD PMID:22427991 NCBI chr13:103,396,295...103,406,759
Ensembl chr13:103,396,314...103,410,363
JBrowse link
G Terf2 telomeric repeat binding factor 2 ISO (PMID:11927518) RGD PMID:11927518 NCBI chr19:39,271,992...39,301,506
Ensembl chr19:39,272,499...39,300,893
JBrowse link
G Tert telomerase reverse transcriptase ISO (PMID:11313459), (PMID:11927518) RGD PMID:11313459, PMID:11927518 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tp63 tumor protein p63 ISO (PMID:19451233) RGD PMID:19451233 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Twist1 twist family bHLH transcription factor 1 ISO (PMID:17690110) RGD PMID:17690110 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
JBrowse link
G Ybx1 Y box binding protein 1 ISS
IEA
GO_REF:0000024
GO_REF:0000107
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr 5:138,319,754...138,336,721
Ensembl chr 5:138,319,762...138,336,475
JBrowse link
G Zkscan3 zinc finger with KRAB and SCAN domains 3 ISO (PMID:23434374) RGD PMID:23434374 NCBI chr17:45,247,724...45,263,422
Ensembl chr17:45,247,776...45,263,418
JBrowse link
oncogene-induced cell senescence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmga1 high mobility group AT-hook 1 ISO
ISS
(PMID:16901784)
GO_REF:0000024
RGD
UniProt
PMID:16901784 GO_REF:0000024 NCBI chr20:7,132,501...7,140,155
Ensembl chr20:7,136,007...7,138,980
JBrowse link
G Hmga2 high mobility group AT-hook 2 ISO
ISS
(PMID:16901784)
GO_REF:0000024
RGD
UniProt
PMID:16901784 GO_REF:0000024 NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408
JBrowse link
oxidative stress-induced premature senescence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arntl aryl hydrocarbon receptor nuclear translocator-like IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5554364|PMID:22101268)
Ensembl
UniProt
RGD
PMID:22101268 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5554364 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
JBrowse link
G Pla2r1 phospholipase A2 receptor 1 ISO
ISS
(PMID:19197340)
GO_REF:0000024
RGD
UniProt
PMID:19197340 GO_REF:0000024 NCBI chr 3:46,488,963...46,621,873
Ensembl chr 3:46,488,186...46,621,873
JBrowse link
G Tp53 tumor protein p53 ISO (PMID:19951988) RGD PMID:19951988 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Wnt16 Wnt family member 16 ISO (PMID:19951988) RGD PMID:19951988 NCBI chr 4:49,369,246...49,388,156
Ensembl chr 4:49,369,296...49,379,703
JBrowse link
positive regulation of cellular senescence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg2 arginase 2 IEA
ISO
GO_REF:0000107
(PMID:22928666)
Ensembl
RGD
PMID:22928666 GO_REF:0000107 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
JBrowse link
G B2m beta-2 microglobulin ISO (PMID:28213472) RGD PMID:28213472 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO (PMID:16901784) RGD PMID:16901784 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cgas cyclic GMP-AMP synthase ISO (MGI:MGI:5909142|PMID:28759028) RGD PMID:28759028 MGI:MGI:5909142 NCBI chr 8:85,789,515...85,804,008
Ensembl chr 8:85,789,763...85,803,433
JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 ISO (PMID:25465621) RGD PMID:25465621 NCBI chr17:26,785,017...26,795,723
Ensembl chr17:26,785,029...26,797,161
JBrowse link
G Hmga1 high mobility group AT-hook 1 ISO
ISS
(PMID:16901784)
GO_REF:0000024
RGD
UniProt
PMID:16901784 GO_REF:0000024 NCBI chr20:7,132,501...7,140,155
Ensembl chr20:7,136,007...7,138,980
JBrowse link
G Hmga2 high mobility group AT-hook 2 ISO
ISS
(PMID:16901784)
GO_REF:0000024
RGD
UniProt
PMID:16901784 GO_REF:0000024 NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408
JBrowse link
G Kras KRAS proto-oncogene, GTPase IMP RGD PMID:17706954 RGD:11060281 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Pawr pro-apoptotic WT1 regulator ISO
IEA
(MGI:MGI:5648604|PMID:25472717)
GO_REF:0000107
RGD
Ensembl
PMID:25472717 GO_REF:0000107, MGI:MGI:5648604 NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
JBrowse link
G Sirt1 sirtuin 1 ISO
IEA
(PMID:18687677)
GO_REF:0000107
RGD
Ensembl
PMID:18687677 GO_REF:0000107 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Stk11 serine/threonine kinase 11 ISO (PMID:20203304) RGD PMID:20203304 NCBI chr 7:12,440,751...12,457,513
Ensembl chr 7:12,440,751...12,457,513
JBrowse link
G Ypel3 yippee-like 3 ISO (PMID:20388804) RGD PMID:20388804 NCBI chr 1:198,210,525...198,213,821
Ensembl chr 1:198,210,525...198,213,816
JBrowse link
regulation of cellular senescence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase ISO MGI:MGI:1338938 (MGI:MGI:5449665|PMID:22729085) RGD PMID:22729085 MGI:MGI:5449665 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5554364|PMID:22101268)
Ensembl
UniProt
RGD
PMID:22101268 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5554364 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A ISO MGI:MGI:87859 (MGI:MGI:5449665|PMID:22729085) RGD PMID:22729085 MGI:MGI:5449665 NCBI chr16:10,758,278...10,852,170
Ensembl chr16:10,758,527...10,802,512
JBrowse link
G Icmt isoprenylcysteine carboxyl methyltransferase ISO MGI:MGI:1890508 (MGI:MGI:5500993|PMID:23686339) RGD PMID:23686339 MGI:MGI:5500993 NCBI chr 5:169,475,270...169,482,031
Ensembl chr 5:169,475,270...169,482,030
JBrowse link
G Ing2 inhibitor of growth family, member 2 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:47,714,756...47,725,836
Ensembl chr16:47,717,951...47,725,836
JBrowse link
G Nek4 NIMA-related kinase 4 ISO (PMID:22851694) RGD PMID:22851694 NCBI chr16:7,035,002...7,080,272
Ensembl chr16:7,035,068...7,075,554
JBrowse link
G Nuak1 NUAK family kinase 1 ISO (PMID:19927127) RGD PMID:19927127 NCBI chr 7:25,039,336...25,111,118
Ensembl chr 7:25,039,335...25,113,664
JBrowse link
G Pnpt1 polyribonucleotide nucleotidyltransferase 1 ISO (PMID:16055741) RGD PMID:16055741 NCBI chr14:113,530,470...113,561,645
Ensembl chr14:113,530,470...113,561,645
JBrowse link
G Rsl1d1 ribosomal L1 domain containing 1 ISO (PMID:18678645) RGD PMID:18678645 NCBI chr10:4,375,329...4,387,195
Ensembl chr10:4,356,915...4,390,030
JBrowse link
G Suv39h1 suppressor of variegation 3-9 homolog 1 ISO MGI:MGI:2445449 (MGI:MGI:5913114|PMID:23695662) RGD PMID:23695662 MGI:MGI:5913114 NCBI chr  X:146,532,002...146,533,538 JBrowse link
G Tp53 tumor protein p53 ISO MGI:MGI:2139971 (MGI:MGI:5504576|PMID:22904064) RGD PMID:22904064 MGI:MGI:5504576 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vash1 vasohibin 1 ISO (PMID:23056314) RGD PMID:23056314 NCBI chr 6:110,624,377...110,640,942
Ensembl chr 6:110,624,856...110,637,382
JBrowse link
G Zfp277 zinc finger protein 277 ISO MGI:MGI:5496522 (MGI:MGI:5496352|PMID:20808772) RGD PMID:20808772 MGI:MGI:5496352 NCBI chr 6:60,246,209...60,374,388
Ensembl chr 6:60,246,214...60,374,389
JBrowse link
G Zmpste24 zinc metallopeptidase STE24 ISO MGI:MGI:1888594|MGI:MGI:2180033 (MGI:MGI:3789238|PMID:16079796), (MGI:MGI:5139938|PMID:21746928), (MGI:MGI:5500993|PMID:23686339) RGD PMID:16079796, PMID:21746928, PMID:23686339 MGI:MGI:3789238, MGI:MGI:5139938, MGI:MGI:5500993 NCBI chr 5:139,982,404...140,015,541
Ensembl chr 5:139,983,680...140,015,541
JBrowse link
stress-induced premature senescence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk14 mitogen activated protein kinase 14 ISO
IEA
(PMID:20160708)
GO_REF:0000107
RGD
Ensembl
PMID:20160708 GO_REF:0000107 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 ISO (PMID:17254968)
(MGI:MGI:3697960|PMID:17254968)
RGD PMID:17254968 MGI:MGI:3697960 NCBI chr12:40,510,378...40,529,332
Ensembl chr12:40,510,378...40,529,338
JBrowse link
G Sirt1 sirtuin 1 ISO
IEA
(PMID:17916362)
GO_REF:0000107
RGD
Ensembl
PMID:17916362 GO_REF:0000107 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    developmental process 6812
      aging 536
        cell aging 157
          cellular senescence 70
            negative regulation of cellular senescence 21
            oncogene-induced cell senescence 2
            positive regulation of cellular senescence 12
            regulation of cellular senescence + 44
            stress-induced premature senescence + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.