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ONTOLOGY REPORT - ANNOTATIONS


Term:endocardial cushion to mesenchymal transition
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Accession:GO:0090500 term browser browse the term
Definition:A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.


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endocardial cushion to mesenchymal transition term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acvrl1 activin A receptor like type 1 JBrowse link 7 142,769,942 142,787,336 RGD:1624291
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:1624291
G Has2 hyaluronan synthase 2 JBrowse link 7 96,438,046 96,464,049 RGD:1624291
RGD:1600115
endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Efna1 ephrin A1 JBrowse link 2 188,588,808 188,596,156 RGD:1624291
RGD:1600115
G Erg ETS transcription factor ERG JBrowse link 11 35,645,317 35,749,637 RGD:1624291
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 JBrowse link 2 95,320,147 95,322,701 RGD:1624291
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 JBrowse link 1 29,191,170 29,201,257 RGD:1624291
RGD:1600115
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Twist1 twist family bHLH transcription factor 1 JBrowse link 6 53,401,241 53,403,235 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18157
    developmental process 6524
      anatomical structure morphogenesis 2762
        animal organ morphogenesis 1117
          heart morphogenesis 279
            cardiac epithelial to mesenchymal transition 37
              endocardial cushion to mesenchymal transition 8
                endocardial cushion to mesenchymal transition involved in cardiac skeleton development 0
                endocardial cushion to mesenchymal transition involved in heart chamber septation 0
                endocardial cushion to mesenchymal transition involved in heart valve formation + 5
                negative regulation of endocardial cushion to mesenchymal transition + 0
                positive regulation of endocardial cushion to mesenchymal transition + 1
                regulation of endocardial cushion to mesenchymal transition + 1
Path 2
Term Annotations click to browse term
  biological_process 18157
    developmental process 6524
      anatomical structure development 6010
        multicellular organism development 5489
          system development 5038
            animal organ development 3855
              mesenchyme development 279
                mesenchymal cell differentiation 219
                  epithelial to mesenchymal transition 142
                    cardiac epithelial to mesenchymal transition 37
                      endocardial cushion to mesenchymal transition 8
                        endocardial cushion to mesenchymal transition involved in cardiac skeleton development 0
                        endocardial cushion to mesenchymal transition involved in heart chamber septation 0
                        endocardial cushion to mesenchymal transition involved in heart valve formation + 5
                        negative regulation of endocardial cushion to mesenchymal transition + 0
                        positive regulation of endocardial cushion to mesenchymal transition + 1
                        regulation of endocardial cushion to mesenchymal transition + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.