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ONTOLOGY REPORT - ANNOTATIONS


Term:sphingolipid mediated signaling pathway
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Accession:GO:0090520 term browser browse the term
Definition:A series of molecular signals mediated by a sphingolipid.
Synonyms:exact_synonym: sphingolipid mediated signal transduction
 narrow_synonym: ceramide 1-phosphate signaling pathway;   ceramide signaling pathway;   sphingosine signaling pathway
 related_synonym: sphingolipid signaling pathway


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sphingolipid mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd3 sphingomyelin phosphodiesterase 3 ISO
IEA
(MGI:MGI:5518963|PMID:23651497)
GO_REF:0000107
RGD
Ensembl
PMID:23651497 GO_REF:0000107, MGI:MGI:5518963 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link
G Sphk1 sphingosine kinase 1 ISO (MGI:MGI:5518963|PMID:23651497) RGD PMID:23651497 MGI:MGI:5518963 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
positive regulation of sphingolipid mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klf14 Kruppel-like factor 14 ISO MGI:MGI:3812953 (MGI:MGI:5588066|PMID:24759103) RGD PMID:24759103 MGI:MGI:5588066 NCBI chr 4:58,247,876...58,250,798
Ensembl chr 4:58,247,876...58,250,798
JBrowse link
regulation of sphingolipid mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plpp3 phospholipid phosphatase 3 ISO
IEA
MGI:MGI:2176173|MGI:MGI:3723633 (MGI:MGI:4939815|PMID:21319224)
GO_REF:0000107
RGD
Ensembl
PMID:21319224 GO_REF:0000107, MGI:MGI:4939815 NCBI chr 5:124,690,214...124,765,499
Ensembl chr 5:124,690,214...124,765,498
JBrowse link
sphingosine-1-phosphate receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ezr ezrin ISO (PMID:23106337) RGD PMID:23106337 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G Gpr6 G protein-coupled receptor 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:45,813,169...45,815,940
Ensembl chr20:45,813,169...45,815,940
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 ISO
IBA
ISS
(PMID:22344443)
PMID:21873635
GO_REF:0000024
(MGI:MGI:2151313|PMID:11032855)
RGD
UniProt
PMID:11032855, PMID:22344443, PMID:21873635 GO_REF:0000024, MGI:MGI:2151313, RGD:13792537 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 ISO
IBA
(PMID:23106337)
PMID:21873635
(MGI:MGI:5470025|PMID:23106337)
RGD PMID:23106337, PMID:21873635 MGI:MGI:5470025, RGD:13792537 NCBI chr 8:21,984,914...21,995,806
Ensembl chr 8:21,984,914...21,995,806
JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr17:13,799,383...13,812,877
Ensembl chr17:13,799,383...13,812,704
JBrowse link
G S1pr4 sphingosine-1-phosphate receptor 4 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:11,077,411...11,079,687
Ensembl chr 7:11,077,411...11,079,687
JBrowse link
G S1pr5 sphingosine-1-phosphate receptor 5 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:22,268,635...22,273,708
Ensembl chr 8:22,268,657...22,270,647
JBrowse link
G Sphk1 sphingosine kinase 1 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
G Sphk2 sphingosine kinase 2 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:101,692,972...101,700,604
Ensembl chr 1:101,692,973...101,697,277
JBrowse link
G Spns2 sphingolipid transporter 2 ISO MGI:MGI:4460276|MGI:MGI:5426395 (MGI:MGI:5424314|PMID:22406534), (MGI:MGI:5490425|PMID:23180825) RGD PMID:22406534, PMID:23180825 MGI:MGI:5424314, MGI:MGI:5490425 NCBI chr10:59,010,428...59,049,482
Ensembl chr10:59,010,428...59,049,482
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    signaling 7588
      signal transduction 7015
        sphingolipid mediated signaling pathway 13
          negative regulation of sphingolipid mediated signaling pathway 0
          positive regulation of sphingolipid mediated signaling pathway 1
          regulation of sphingolipid mediated signaling pathway + 2
          sphingosine-1-phosphate receptor signaling pathway 10
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        regulation of cellular process 12560
          signal transduction 7015
            sphingolipid mediated signaling pathway 13
              negative regulation of sphingolipid mediated signaling pathway 0
              positive regulation of sphingolipid mediated signaling pathway 1
              regulation of sphingolipid mediated signaling pathway + 2
              sphingosine-1-phosphate receptor signaling pathway 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.