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ONTOLOGY REPORT - ANNOTATIONS


Term:site of DNA damage
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Accession:GO:0090734 term browser browse the term
Definition:A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
Synonyms:xref: Wikipedia:DNA_repair


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site of DNA damage term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADPRS ADP-ribosylserine hydrolase JBrowse link 6 92,238,467 92,244,515 RGD:14298760
G AUNIP aurora kinase A and ninein interacting protein JBrowse link 6 83,276,977 83,316,642 RGD:14298760
G CBX1 chromobox 1 JBrowse link 12 24,319,104 24,351,057 RGD:14298760
G CBX3 chromobox 3 JBrowse link 18 46,193,138 46,205,114 RGD:14298760
G CBX5 chromobox 5 JBrowse link 5 19,446,083 19,484,527 RGD:14298760
G CUL5 cullin 5 JBrowse link 9 36,419,806 36,507,681 RGD:14298760
G ELOA elongin A JBrowse link 6 81,564,792 81,582,049 RGD:9068941
G ERCC6 ERCC excision repair 6, chromatin remodeling factor JBrowse link 14 89,998,125 90,075,911 RGD:14298760
G EXD2 exonuclease 3'-5' domain containing 2 JBrowse link 7 92,847,958 92,909,044 RGD:14298760
G HROB homologous recombination factor with OB-fold JBrowse link 12 19,044,569 19,077,877 RGD:14298760
G KAT7 lysine acetyltransferase 7 JBrowse link 12 25,970,966 26,005,006 RGD:9068941
G LOC100522201 histone H2AX JBrowse link 9 46,308,824 46,310,494 RGD:9068941
G NKX3-1 NK3 homeobox 1 JBrowse link 14 7,783,296 7,787,036 RGD:14298760
G OARD1 O-acyl-ADP-ribose deacylase 1 JBrowse link 7 36,378,515 36,386,408 RGD:14298760
G PARP1 poly(ADP-ribose) polymerase 1 JBrowse link 10 14,203,157 14,241,164 RGD:9068941
G PARP9 poly(ADP-ribose) polymerase family member 9 JBrowse link 13 137,960,987 138,000,862 RGD:14298760
G POLK DNA polymerase kappa JBrowse link 2 84,555,648 84,619,490 RGD:14298760
RGD:9068941
G RFWD3 ring finger and WD repeat domain 3 JBrowse link 6 12,952,243 12,994,053 RGD:9068941
G RPA1 replication protein A1 JBrowse link 12 48,009,652 48,048,744 RGD:14298760
G SLFN11 schlafen family member 11 JBrowse link 12 39,974,519 39,996,257 RGD:9068941
G UBQLN4 ubiquilin 4 JBrowse link 4 93,976,386 93,994,830 RGD:14298760
G WDR76 WD repeat domain 76 JBrowse link 1 127,651,765 127,741,357 RGD:14298760
G XPC XPC complex subunit, DNA damage recognition and repair factor JBrowse link 13 70,348,841 70,397,194 RGD:14298760
G XRCC5 X-ray repair cross complementing 5 JBrowse link 15 118,354,943 118,451,974 RGD:9068941
site of double-strand break term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACTR2 actin related protein 2 JBrowse link 3 76,691,275 76,729,269 RGD:14298760
G APLF aprataxin and PNKP like factor JBrowse link 3 73,752,115 73,831,158 RGD:14298760
G ATF2 activating transcription factor 2 JBrowse link 15 80,984,969 81,076,573 RGD:14298760
G CGAS cyclic GMP-AMP synthase JBrowse link 1 92,483,253 92,500,376 RGD:14298760
G CMTR1 cap methyltransferase 1 JBrowse link 7 33,000,499 33,063,739 RGD:14298760
G CNTD1 cyclin N-terminal domain containing 1 JBrowse link 12 20,054,572 20,062,754 RGD:14298760
G ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 JBrowse link 14 11,495,297 11,532,898 RGD:9068941
G FH fumarate hydratase JBrowse link 10 12,404,143 12,431,843 RGD:9068941
G HELB DNA helicase B JBrowse link 5 30,645,378 30,696,488 RGD:14298760
G HUS1 HUS1 checkpoint clamp component JBrowse link 18 48,522,914 48,539,267 RGD:14298760
G LOC100514009 histone-lysine N-methyltransferase SETMAR JBrowse link 13 60,914,412 60,933,064 RGD:9068941
G LOC100522201 histone H2AX JBrowse link 9 46,308,824 46,310,494 RGD:9068941
G LOC100627380 lysine-specific demethylase 4D-like JBrowse link 9 27,083,348 27,085,693 RGD:9068941
G LOC110256637 SMC5-SMC6 complex localization factor protein 2 JBrowse link 14 111,996,781 112,049,309 RGD:14298760
G MRE11 MRE11 homolog, double strand break repair nuclease JBrowse link 9 26,572,352 26,634,596 RGD:14298760
G NBN nibrin JBrowse link 4 46,787,664 46,854,331 RGD:14298760
G PARP1 poly(ADP-ribose) polymerase 1 JBrowse link 10 14,203,157 14,241,164 RGD:14298760
G PARP3 poly(ADP-ribose) polymerase family member 3 JBrowse link 13 34,075,807 34,084,384 RGD:14298760
G PAXX PAXX non-homologous end joining factor RGD:14298760
G PHF1 PHD finger protein 1 JBrowse link 7 29,714,295 29,719,996 RGD:14298760
G POLH DNA polymerase eta JBrowse link 7 38,569,211 38,601,794 RGD:14298760
G PRPF19 pre-mRNA processing factor 19 JBrowse link 2 10,851,779 10,860,315 RGD:14298760
G RAD18 RAD18 E3 ubiquitin protein ligase JBrowse link 13 65,253,416 65,359,506 RGD:14298760
G RAD50 RAD50 double strand break repair protein JBrowse link 2 134,844,460 134,939,188 RGD:14298760
G RAD51 RAD51 recombinase JBrowse link 1 130,592,414 130,640,326 RGD:14298760
G RFWD3 ring finger and WD repeat domain 3 JBrowse link 6 12,952,243 12,994,053 RGD:14298760
RGD:9068941
G RIF1 replication timing regulatory factor 1 JBrowse link 15 769,518 832,036 RGD:14298760
G RNF138 ring finger protein 138 JBrowse link 6 115,927,021 115,975,754 RGD:14298760
G RNF168 ring finger protein 168 JBrowse link 13 133,625,534 133,659,253 RGD:9068941
G RNF169 ring finger protein 169 JBrowse link 9 9,069,776 9,177,367 RGD:14298760
G RNF8 ring finger protein 8 JBrowse link 7 32,931,786 32,969,536 RGD:14298760
G RPA2 replication protein A2 JBrowse link 6 85,032,604 85,045,899 RGD:14298760
RGD:9068941
G RPA3 replication protein A3 JBrowse link 9 77,910,876 77,914,872 RGD:14298760
G SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 JBrowse link 17 40,117,348 40,171,935 RGD:14298760
G SHLD1 shieldin complex subunit 1 JBrowse link 17 14,610,723 14,706,082 RGD:14298760
G SHLD2 shieldin complex subunit 2 JBrowse link 14 88,005,599 88,121,155 RGD:14298760
G SIRT7 sirtuin 7 JBrowse link 12 1,078,155 1,084,112 RGD:14298760
G SLF1 SMC5-SMC6 complex localization factor 1 JBrowse link 2 101,286,744 101,375,612 RGD:14298760
G SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 JBrowse link 8 125,410,221 125,488,471 RGD:14298760
G SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1 JBrowse link 15 118,627,734 118,688,005 RGD:14298760
G SMC5 structural maintenance of chromosomes 5 JBrowse link 1 223,560,271 223,653,370 RGD:9068941
G SMC6 structural maintenance of chromosomes 6 JBrowse link 3 120,097,361 120,170,974 RGD:14298760
G SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 JBrowse link 6 103,809,732 103,986,057 RGD:14298760
G TIMELESS timeless circadian regulator RGD:14298760
G TP53 tumor protein p53 JBrowse link 12 52,939,643 52,953,786 RGD:14298760
G TP53BP1 tumor protein p53 binding protein 1 JBrowse link 1 127,958,500 128,032,370 RGD:14298760
G UFL1 UFM1 specific ligase 1 JBrowse link 1 63,638,589 63,698,931 RGD:9068941
G VCP valosin containing protein JBrowse link 1 235,854,532 235,869,712 RGD:14298760
G WAS WASP actin nucleation promoting factor JBrowse link X 42,774,597 42,793,055 RGD:14298760
G WDR70 WD repeat domain 70 JBrowse link 16 22,599,904 22,891,927 RGD:14298760
G WRAP53 WD repeat containing antisense to TP53 JBrowse link 12 52,954,674 52,968,371 RGD:14298760
G XRCC4 X-ray repair cross complementing 4 JBrowse link 2 91,358,348 91,643,697 RGD:9068941
G ZBTB7A zinc finger and BTB domain containing 7A JBrowse link 2 74,678,293 74,699,347 RGD:14298760
RGD:9068941
G ZGRF1 zinc finger GRF-type containing 1 JBrowse link 8 110,089,920 110,168,086 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 16659
    cellular anatomical entity 16497
      site of DNA damage 75
        site of double-strand break 54
Path 2
Term Annotations click to browse term
  cellular_component 16659
    cellular anatomical entity 16497
      organelle 11174
        non-membrane-bounded organelle 3894
          intracellular non-membrane-bounded organelle 3874
            chromosome 973
              site of DNA damage 75
                site of double-strand break 54
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.