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ONTOLOGY REPORT - ANNOTATIONS


Term:telomere maintenance via telomere trimming
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Accession:GO:0090737 term browser browse the term
Definition:A process that contributes to the maintenance of proper telomeric length and structure via the activation of telomere shortening pathways that compensate telomerase-dependent excessive telomere elongation. Telomere attrition is mediated by a mechanism which involves the generation of single-stranded C-rich telomeric DNA, and the formation and removal of double-stranded telomeric circular DNA (T-circles). Telomere trimming is an independent pathway to recombination-mediated telomere elongation and the well-documented gradual telomere attrition that accompanies cellular replication.


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telomere maintenance via telomere trimming term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nbn nibrin JBrowse link 5 29,622,347 29,656,877 RGD:1624291
G Xrcc3 X-ray repair cross complementing 3 JBrowse link 6 136,366,917 136,380,751 RGD:1624291
negative regulation of t-circle formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rtel1 regulator of telomere elongation helicase 1 JBrowse link 3 176,818,012 176,856,531 RGD:1624291
RGD:13792537
G Terf2 telomeric repeat binding factor 2 JBrowse link 19 39,271,992 39,301,506 RGD:1624291
G Xrcc5 X-ray repair cross complementing 5 JBrowse link 9 79,659,275 79,748,050 RGD:1624291
positive regulation of t-circle formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:1624291
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit JBrowse link 1 198,114,514 198,120,061 RGD:1624291
G Slx4 SLX4 structure-specific endonuclease subunit JBrowse link 10 11,787,756 11,808,326 RGD:1624291
t-circle formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:1624291
G Nbn nibrin JBrowse link 5 29,622,347 29,656,877 RGD:1624291
RGD:1600115
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit JBrowse link 1 198,114,514 198,120,061 RGD:1624291
G Slx4 SLX4 structure-specific endonuclease subunit JBrowse link 10 11,787,756 11,808,326 RGD:1624291
G Xrcc3 X-ray repair cross complementing 3 JBrowse link 6 136,366,917 136,380,751 RGD:1624291
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19439
    biological regulation 13446
      regulation of biological quality 4275
        homeostatic process 2049
          anatomical structure homeostasis 435
            telomere maintenance 126
              telomere maintenance via telomere trimming 8
                t-circle formation + 8
Path 2
Term Annotations click to browse term
  biological_process 19439
    cellular process 18179
      cellular metabolic process 10644
        cellular nitrogen compound metabolic process 6382
          nucleobase-containing compound metabolic process 5278
            nucleic acid metabolic process 4788
              DNA metabolic process 885
                telomere maintenance 126
                  telomere maintenance via telomere trimming 8
                    t-circle formation + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.