ONTOLOGY REPORT - ANNOTATIONS


Term:execution phase of apoptosis
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Accession:GO:0097194 term browser browse the term
Definition:A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
Synonyms:exact_synonym: execution phase of apoptotic process
 narrow_synonym: apoptosis


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execution phase of apoptosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aifm3 apoptosis inducing factor, mitochondria associated 3 JBrowse link 11 87,364,452 87,380,705 RGD:1624291
RGD:1600115
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:1624291
RGD:1600115
G Bbc3 Bcl-2 binding component 3 JBrowse link 1 78,261,491 78,267,802 RGD:1624291
RGD:13792537
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:13792537
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:13792537
G Casp2 caspase 2 JBrowse link 4 71,652,358 71,670,228 RGD:1600115
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:1624291
RGD:1600115
G Casp4 caspase 4 JBrowse link 8 2,616,391 2,651,682 RGD:13792537
G Casp6 caspase 6 JBrowse link 2 235,341,326 235,353,715 RGD:1600115
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:1624291
RGD:1600115
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:1624291
RGD:13792537
RGD:1600115
G Cecr2 CECR2, histone acetyl-lysine reader JBrowse link 4 153,217,521 153,327,153 RGD:1624291
G Cideb cell death-inducing DFFA-like effector b JBrowse link 15 34,439,844 34,444,244 RGD:1624291
G Cidec cell death-inducing DFFA-like effector c JBrowse link 4 145,377,482 145,390,497 RGD:1624291
G LOC103689977 caspase-6 JBrowse link 2 230,186,170 230,198,555 RGD:1600115
G Madd MAP-kinase activating death domain JBrowse link 3 79,960,301 80,003,023 RGD:1600115
RGD:1624291
G Stk24 serine/threonine kinase 24 JBrowse link 15 106,629,258 106,678,917 RGD:1600115
RGD:1624291
G Taok1 TAO kinase 1 JBrowse link 10 62,542,870 62,630,341 RGD:1600115
RGD:13792537
RGD:1624291
apoptotic chromosome condensation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acin1 apoptotic chromatin condensation inducer 1 JBrowse link 15 33,288,369 33,333,256 RGD:1624291
RGD:1600115
G Dffb DNA fragmentation factor subunit beta JBrowse link 5 171,250,559 171,261,875 RGD:1624291
G Ern2 endoplasmic reticulum to nucleus signaling 2 JBrowse link 1 192,126,023 192,142,865 RGD:1624291
RGD:1600115
G Gper1 G protein-coupled estrogen receptor 1 JBrowse link 12 17,309,122 17,315,267 RGD:8553942
G Top2a DNA topoisomerase II alpha JBrowse link 10 86,901,467 86,930,947 RGD:1600115
RGD:13792537
RGD:1624291
apoptotic DNA fragmentation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dffa DNA fragmentation factor subunit alpha JBrowse link 5 165,922,893 165,935,822 RGD:1600115
G Dffb DNA fragmentation factor subunit beta JBrowse link 5 171,250,559 171,261,875 RGD:628524
RGD:1600115
RGD:13792537
RGD:1624291
G Dicer1 dicer 1 ribonuclease III JBrowse link 6 128,388,084 128,453,234 RGD:13792537
G Dnase1l3 deoxyribonuclease 1-like 3 JBrowse link 15 18,710,492 18,736,476 RGD:728743
RGD:13792537
RGD:1624291
G Dnase2 deoxyribonuclease 2, lysosomal JBrowse link 19 26,022,855 26,025,523 RGD:13792537
G Dnase2b deoxyribonuclease 2 beta JBrowse link 2 252,436,363 252,475,506 RGD:13792537
G Endog endonuclease G JBrowse link 3 8,741,833 8,744,414 RGD:1624291
RGD:13792537
G Exog exo/endonuclease G JBrowse link 8 128,133,398 128,153,110 RGD:13792537
G Foxl2 forkhead box L2 JBrowse link 8 107,194,492 107,197,644 RGD:1624291
RGD:1600115
apoptotic nuclear changes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acvr1c activin A receptor type 1C JBrowse link 3 44,272,859 44,342,501 RGD:1600115
RGD:1624291
G Blcap BLCAP, apoptosis inducing factor JBrowse link 3 154,040,165 154,042,096 RGD:1624291
RGD:1600115
G Cd24 CD24 molecule JBrowse link 20 48,335,540 48,340,847 RGD:1624291
RGD:1600115
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 JBrowse link 10 84,780,644 84,789,800 RGD:1600115
RGD:1624291
G Dedd2 death effector domain containing 2 JBrowse link 1 82,073,024 82,089,028 RGD:1624291
RGD:1600115
G Sharpin SHANK-associated RH domain interactor JBrowse link 7 117,413,151 117,417,455 RGD:1624291
RGD:1600115
cellular component disassembly involved in execution phase of apoptosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bok BCL2 family apoptosis regulator BOK JBrowse link 9 100,829,593 100,840,498 RGD:1624291
RGD:1600115
negative regulation of apoptotic DNA fragmentation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dffa DNA fragmentation factor subunit alpha JBrowse link 5 165,922,893 165,935,822 RGD:1624291
RGD:1600115
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 JBrowse link 5 166,409,460 166,430,291 RGD:13781945
G Pam16 presequence translocase associated motor 16 JBrowse link 10 11,146,359 11,153,936 RGD:13462066
negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOC100910732 serine/threonine-protein kinase PAK 2-like JBrowse link 11 71,959,058 72,021,252 RGD:13792537
G Pak2 p21 (RAC1) activated kinase 2 JBrowse link 11 72,829,407 72,865,815 RGD:1624291
RGD:13792537
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase JBrowse link 10 70,157,621 70,220,618 RGD:1624291
RGD:1600115
G Rnf34 ring finger protein 34 JBrowse link 12 39,164,290 39,185,209 RGD:1624291
RGD:1600115
negative regulation of execution phase of apoptosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:1624291
RGD:1600115
G Cidea cell death-inducing DFFA-like effector a JBrowse link 18 63,082,861 63,108,450 RGD:1624291
G Cxcr3 C-X-C motif chemokine receptor 3 JBrowse link X 71,614,346 71,616,997 RGD:1624291
RGD:1600115
G Dffa DNA fragmentation factor subunit alpha JBrowse link 5 165,922,893 165,935,822 RGD:1624291
RGD:13792537
G Fzd3 frizzled class receptor 3 JBrowse link 15 48,601,259 48,670,257 RGD:1624291
RGD:1600115
G Gcg glucagon JBrowse link 3 48,442,635 48,451,650 RGD:1624291
RGD:1600115
nuclear fragmentation involved in apoptotic nuclear change term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gper1 G protein-coupled estrogen receptor 1 JBrowse link 12 17,309,122 17,315,267 RGD:8553942
phosphatidylserine exposure on apoptotic cell surface term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ano6 anoctamin 6 JBrowse link 7 137,142,063 137,335,208 RGD:1624291
G Plscr1 phospholipid scramblase 1 JBrowse link 8 99,625,523 99,645,882 RGD:1624291
RGD:13792537
RGD:1600115
G Xkr4 XK related 4 JBrowse link 5 15,746,012 16,141,059 RGD:13792537
G Xkr6 XK related 6 JBrowse link 15 46,784,963 47,173,352 RGD:13792537
G Xkr7 XK related 7 JBrowse link 3 148,508,622 148,537,904 RGD:13792537
G Xkr8 XK related 8 JBrowse link 5 150,918,600 150,925,727 RGD:1624291
RGD:13792537
G Xkr9 XK related 9 JBrowse link 5 4,946,332 4,975,436 RGD:13792537
positive regulation of apoptotic DNA fragmentation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1624291
RGD:1600115
G Endog endonuclease G JBrowse link 3 8,741,833 8,744,414 RGD:9685355
G Hsf1 heat shock transcription factor 1 JBrowse link 7 117,538,523 117,565,478 RGD:10403035
G Igfbp3 insulin-like growth factor binding protein 3 JBrowse link 14 87,457,647 87,465,374 RGD:10402776
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1624291
positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rps3 ribosomal protein S3 JBrowse link 1 164,435,868 164,441,167 RGD:1624291
positive regulation of execution phase of apoptosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bok BCL2 family apoptosis regulator BOK JBrowse link 9 100,829,593 100,840,498 RGD:1624291
RGD:1600115
G Cxcr3 C-X-C motif chemokine receptor 3 JBrowse link X 71,614,346 71,616,997 RGD:1624291
G Dlc1 DLC1 Rho GTPase activating protein JBrowse link 16 58,776,489 59,247,752 RGD:1600115
RGD:1624291
G Fap fibroblast activation protein, alpha JBrowse link 3 48,467,781 48,536,242 RGD:1624291
RGD:1600115
G Ptgis prostaglandin I2 synthase JBrowse link 3 163,950,746 163,986,129 RGD:1624291
RGD:1600115
G Sirt2 sirtuin 2 JBrowse link 1 86,948,866 86,971,954 RGD:1600115
RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Tp53bp2 tumor protein p53 binding protein, 2 JBrowse link 13 100,817,206 100,873,837 RGD:1624291
RGD:1600115
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 5 143,111,342 143,120,131 RGD:1624291
RGD:1600115
regulation of apoptotic DNA fragmentation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aifm1 apoptosis inducing factor, mitochondria associated 1 JBrowse link X 135,304,063 135,343,062 RGD:1624291
RGD:1600115
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 7 31,699,309 31,784,192 RGD:1624291
RGD:1600115
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:1624291
G Cidea cell death-inducing DFFA-like effector a JBrowse link 18 63,082,861 63,108,450 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17896
    cellular process 16040
      execution phase of apoptosis 71
        cellular component disassembly involved in execution phase of apoptosis + 30
        negative regulation of execution phase of apoptosis + 12
        phosphatidylserine exposure on apoptotic cell surface + 7
        positive regulation of execution phase of apoptosis + 15
        regulation of execution phase of apoptosis + 29
Path 2
Term Annotations click to browse term
  biological_process 17896
    cellular process 16040
      cell death 2087
        programmed cell death 1915
          apoptotic process 1871
            execution phase of apoptosis 71
              cellular component disassembly involved in execution phase of apoptosis + 30
              negative regulation of execution phase of apoptosis + 12
              phosphatidylserine exposure on apoptotic cell surface + 7
              positive regulation of execution phase of apoptosis + 15
              regulation of execution phase of apoptosis + 29
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.