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Term:R2TP complex
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Accession:GO:0097255 term browser browse the term
Definition:A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.

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R2TP complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PIH1D1 PIH1 domain containing 1 JBrowse link 6 54,524,172 54,529,700 RGD:14298760
G PIH1D2 PIH1 domain containing 2 JBrowse link 9 39,767,708 39,775,477 RGD:14298760
G RPAP3 RNA polymerase II associated protein 3 JBrowse link 5 77,968,171 78,066,252 RGD:14298760
G RUVBL1 RuvB like AAA ATPase 1 JBrowse link 13 72,196,219 72,246,514 RGD:14298760
G RUVBL2 RuvB like AAA ATPase 2 JBrowse link 6 54,250,494 54,263,492 RGD:14298760

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  cellular_component 16659
    protein-containing complex 4951
      R2TP complex 5
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.