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ONTOLOGY REPORT - ANNOTATIONS


Term:complement-dependent cytotoxicity
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Accession:GO:0097278 term browser browse the term
Definition:Cell killing caused by the membrane attack complex formed following complement activation.


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complement-dependent cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 IEA
ISO
GO_REF:0000107
(MGI:5617896|PMID:25284781)
Ensembl
RGD
PMID:25284781 GO_REF:0000107, MGI:5617896 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Rab27a RAB27A, member RAS oncogene family ISO (PMID:24404184) RGD PMID:24404184 NCBI chr 8:79,722,334...79,776,228
Ensembl chr 8:79,722,334...79,776,221
JBrowse link
negative regulation of complement-dependent cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd59 CD59 molecule IMP RGD PMID:28212662 RGD:13792592 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621
JBrowse link
G Cldn5 claudin 5 ISO (PMID:24280217) RGD PMID:24280217 NCBI chr11:86,356,292...86,357,718
Ensembl chr11:86,356,294...86,357,718
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 IMP oligodendrocyte precursor cells RGD PMID:16135098 RGD:10448271 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Il13 interleukin 13 ISO (PMID:16034134) RGD PMID:16034134 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il4 interleukin 4 ISO
IBA
(PMID:16034134)
PMID:21873635
(PMID:16034134), (PMID:24280217)
RGD PMID:16034134, PMID:24280217, PMID:21873635 RGD:13792537 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Jak3 Janus kinase 3 ISO (PMID:24280217) RGD PMID:24280217 NCBI chr16:20,107,471...20,120,678
Ensembl chr16:20,109,200...20,120,668
JBrowse link
G Stat6 signal transducer and activator of transcription 6 ISO (PMID:24280217) RGD PMID:24280217 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
positive regulation of complement-dependent cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd5l Cd5 molecule-like ISO MGI:2653296 (MGI:5617896|PMID:25284781) RGD PMID:25284781 MGI:5617896 NCBI chr 2:186,685,104...186,696,117
Ensembl chr 2:186,685,104...186,696,117
JBrowse link
G Foxo1 forkhead box O1 ISO (PMID:24280217) RGD PMID:24280217 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
regulation of complement-dependent cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) ISO (PMID:25284781) RGD PMID:25284781 NCBI chr13:47,125,156...47,153,557
Ensembl chr13:47,126,741...47,154,292
JBrowse link
G Cd59 CD59 molecule ISO (PMID:25284781) RGD PMID:25284781 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621
JBrowse link
G Cdh5 cadherin 5 ISO (PMID:24280217) RGD PMID:24280217 NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365
JBrowse link
G Cfh complement factor H ISO (PMID:25284781) RGD PMID:25284781 NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622
JBrowse link
G Cr1l complement C3b/C4b receptor 1 like ISO (PMID:25284781) RGD PMID:25284781 NCBI chr13:113,824,886...113,872,097
Ensembl chr13:113,824,892...113,872,097
JBrowse link
G Il10 interleukin 10 NOT ISO (PMID:16034134) RGD PMID:16034134 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il11 interleukin 11 NOT ISO (PMID:16034134) RGD PMID:16034134 NCBI chr 1:72,636,959...72,643,255
Ensembl chr 1:72,635,267...72,643,255
JBrowse link
G Tgfb2 transforming growth factor, beta 2 NOT ISO (PMID:16034134) RGD PMID:16034134 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      cell killing 209
        complement-dependent cytotoxicity 18
          negative regulation of complement-dependent cytotoxicity 7
          positive regulation of complement-dependent cytotoxicity 2
          regulation of complement-dependent cytotoxicity + 16
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.