Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
go back to main search page
Accession:GO:0097296 term browser browse the term
Definition:Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway.
Comment:Components of the DISC (death-inducing signaling complex) may be annotated to this term. These include ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer), and signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Note that GO:0097296 should only be used to annotate gene products directly involved in the initiation or start up of an inactive cysteine-type endopeptidase activity involved in the apoptotic signaling pathway (also known as an initiator caspase). If the evidence provided is not sufficient to account for direct activation of this enzymatic activity, consider using the more generic terms GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway or GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process.
Synonyms:exact_synonym: activation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway
 narrow_synonym: activation of initiator caspase activity


show annotations for term's descendants       view all columns           Sort by:
 
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1624291
RGD:1600115
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1624291
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:2301029

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18166
    cellular process 16266
      signal transduction 6597
        positive regulation of signal transduction 1596
          positive regulation of apoptotic signaling pathway 185
            positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 10
              activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 3
Path 2
Term Annotations click to browse term
  biological_process 18166
    metabolic process 10845
      organic substance metabolic process 10283
        macromolecule metabolic process 8818
          protein metabolic process 5590
            cellular protein metabolic process 4932
              regulation of cellular protein metabolic process 2658
                positive regulation of cellular protein metabolic process 1620
                  positive regulation of proteolysis 357
                    positive regulation of peptidase activity 185
                      positive regulation of endopeptidase activity 168
                        positive regulation of cysteine-type endopeptidase activity 147
                          positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 130
                            positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 10
                              activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 3
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.