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ONTOLOGY REPORT - ANNOTATIONS


Term:hypoxia-inducible factor-1alpha signaling pathway
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Accession:GO:0097411 term browser browse the term
Definition:A series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia.
Synonyms:exact_synonym: HIF1alpha pathway;   hypoxia-inducible factor signaling;   hypoxia-inducible factor-1alpha signalling pathway


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hypoxia-inducible factor-1alpha signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cybb cytochrome b-245 beta chain JBrowse link X 14,578,330 14,610,049 RGD:11040609
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:1624291
RGD:1600115
G Pdk1 pyruvate dehydrogenase kinase 1 JBrowse link 3 58,530,870 58,561,494 RGD:1600115
RGD:1624291
G Pdk3 pyruvate dehydrogenase kinase 3 JBrowse link X 62,836,131 62,904,114 RGD:1624291
negative regulation of hypoxia-inducible factor-1alpha signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Commd1 copper metabolism domain containing 1 JBrowse link 14 107,664,321 107,759,974 RGD:1624291
G Vhl von Hippel-Lindau tumor suppressor JBrowse link 4 145,580,869 145,587,835 RGD:1624291
positive regulation of hypoxia-inducible factor-1alpha signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rwdd3 RWD domain containing 3 JBrowse link 2 224,710,351 224,723,136 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    cellular process 18617
      signal transduction 6968
        hypoxia-inducible factor-1alpha signaling pathway 7
          negative regulation of hypoxia-inducible factor-1alpha signaling pathway 2
          positive regulation of hypoxia-inducible factor-1alpha signaling pathway 1
          regulation of hypoxia-inducible factor-1alpha signaling pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 19858
    response to stimulus 10526
      cellular response to stimulus 8858
        cellular response to chemical stimulus 3497
          cellular response to oxygen levels 229
            cellular response to decreased oxygen levels 209
              cellular response to hypoxia 182
                hypoxia-inducible factor-1alpha signaling pathway 7
                  negative regulation of hypoxia-inducible factor-1alpha signaling pathway 2
                  positive regulation of hypoxia-inducible factor-1alpha signaling pathway 1
                  regulation of hypoxia-inducible factor-1alpha signaling pathway + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.