Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


Term:GAIT complex
go back to main search page
Accession:GO:0097452 term browser browse the term
Definition:A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP.
Synonyms:exact_synonym: IFN-gamma-activated inhibitor of translation complex;   gamma interferon-activated inhibitor of translation complex

show annotations for term's descendants       view all columns           Sort by:
GAIT complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eprs glutamyl-prolyl-tRNA synthetase JBrowse link 13 103,300,911 103,371,651 RGD:1624291
G Gapdh glyceraldehyde-3-phosphate dehydrogenase JBrowse link 4 157,676,336 157,680,322 RGD:1624291
G LOC108351137 glyceraldehyde-3-phosphate dehydrogenase JBrowse link 5 115,649,077 115,650,141 RGD:1600115
G Rpl13a ribosomal protein L13A JBrowse link 1 101,120,325 101,123,401 RGD:1624291
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein JBrowse link 8 96,100,692 96,266,342 RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19949
    protein-containing complex 5829
      GAIT complex 5
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.