Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:ubiquitin-dependent glycoprotein ERAD pathway
go back to main search page
Accession:GO:0097466 term browser browse the term
Definition:An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component.
Synonyms:exact_synonym: ER-associated glycoprotein degradation;   glycoprotein ERAD;   gpERAD
 broad_synonym: misfolded or incompletely synthesized glycoprotein catabolic process


show annotations for term's descendants       view all columns           Sort by:
 
ubiquitin-dependent glycoprotein ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link 3 5,187,707 5,219,963 RGD:2290271
G EDEM2 ER degradation enhancing alpha-mannosidase like protein 2 JBrowse link 20 35,115,364 35,147,336 RGD:2290271
mannose trimming involved in glycoprotein ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link 3 5,187,707 5,219,963 RGD:2290271
G EDEM2 ER degradation enhancing alpha-mannosidase like protein 2 JBrowse link 20 35,115,364 35,147,336 RGD:2290271
G EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 JBrowse link 1 184,690,237 184,754,907 RGD:2290271
G MAN1B1 mannosidase alpha class 1B member 1 JBrowse link 9 137,086,941 137,109,183 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18104
    response to stimulus 9452
      response to chemical 4918
        response to oxygen-containing compound 1735
          response to glycoprotein 6
            ubiquitin-dependent glycoprotein ERAD pathway 4
              mannose trimming involved in glycoprotein ERAD pathway 4
Path 2
Term Annotations click to browse term
  biological_process 18104
    metabolic process 11847
      organic substance metabolic process 11269
        macromolecule metabolic process 9763
          macromolecule catabolic process 1478
            protein catabolic process 990
              cellular protein catabolic process 820
                proteolysis involved in cellular protein catabolic process 760
                  modification-dependent protein catabolic process 668
                    ubiquitin-dependent protein catabolic process 662
                      proteasome-mediated ubiquitin-dependent protein catabolic process 440
                        ubiquitin-dependent ERAD pathway 81
                          ubiquitin-dependent glycoprotein ERAD pathway 4
                            mannose trimming involved in glycoprotein ERAD pathway 4
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.