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ONTOLOGY REPORT - ANNOTATIONS


Term:ubiquitin-dependent glycoprotein ERAD pathway
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Accession:GO:0097466 term browser browse the term
Definition:An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component.
Synonyms:exact_synonym: ER-associated glycoprotein degradation;   glycoprotein ERAD;   gpERAD
 broad_synonym: misfolded or incompletely synthesized glycoprotein catabolic process


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ubiquitin-dependent glycoprotein ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Edem1 ER degradation enhancer, mannosidase alpha-like 1 JBrowse link 6 108,824,045 108,859,356 RGD:2290270
G Edem2 ER degradation enhancer, mannosidase alpha-like 2 JBrowse link 2 155,701,673 155,729,475 RGD:2290270
G Fbxo6 F-box protein 6 JBrowse link 4 148,145,716 148,152,135 RGD:2290270
mannose trimming involved in glycoprotein ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Edem1 ER degradation enhancer, mannosidase alpha-like 1 JBrowse link 6 108,824,045 108,859,356 RGD:2290270
G Edem2 ER degradation enhancer, mannosidase alpha-like 2 JBrowse link 2 155,701,673 155,729,475 RGD:2290270
G Edem3 ER degradation enhancer, mannosidase alpha-like 3 JBrowse link 1 151,755,344 151,822,328 RGD:2290270
G Man1b1 mannosidase, alpha, class 1B, member 1 JBrowse link 2 25,332,730 25,352,213 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23162
    response to stimulus 9760
      response to chemical 4576
        response to oxygen-containing compound 1663
          response to glycoprotein 6
            ubiquitin-dependent glycoprotein ERAD pathway 5
              mannose trimming involved in glycoprotein ERAD pathway 4
Path 2
Term Annotations click to browse term
  biological_process 23162
    metabolic process 10900
      organic substance metabolic process 10349
        macromolecule metabolic process 8877
          macromolecule catabolic process 1273
            protein catabolic process 934
              cellular protein catabolic process 774
                proteolysis involved in cellular protein catabolic process 724
                  modification-dependent protein catabolic process 620
                    ubiquitin-dependent protein catabolic process 609
                      proteasome-mediated ubiquitin-dependent protein catabolic process 406
                        ubiquitin-dependent ERAD pathway 76
                          ubiquitin-dependent glycoprotein ERAD pathway 5
                            mannose trimming involved in glycoprotein ERAD pathway 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.