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ONTOLOGY REPORT - ANNOTATIONS


Term:ubiquitin-dependent glycoprotein ERAD pathway
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Accession:GO:0097466 term browser browse the term
Definition:An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component.
Synonyms:exact_synonym: ER-associated glycoprotein degradation;   glycoprotein ERAD;   gpERAD
 broad_synonym: misfolded or incompletely synthesized glycoprotein catabolic process


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ubiquitin-dependent glycoprotein ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link NW_004936577 4,486,617 4,516,379 RGD:9068941
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 JBrowse link NW_004936561 5,578,267 5,605,512 RGD:9068941
mannose trimming involved in glycoprotein ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link NW_004936577 4,486,617 4,516,379 RGD:9068941
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 JBrowse link NW_004936561 5,578,267 5,605,512 RGD:9068941
G Edem3 ER degradation enhancing alpha-mannosidase like protein 3 JBrowse link NW_004936481 5,352,964 5,424,944 RGD:9068941
G Man1b1 mannosidase alpha class 1B member 1 JBrowse link NW_004936669 855,349 867,763 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14835
    response to stimulus 7845
      response to chemical 4109
        response to oxygen-containing compound 1585
          response to glycoprotein 6
            ubiquitin-dependent glycoprotein ERAD pathway 4
              mannose trimming involved in glycoprotein ERAD pathway 4
Path 2
Term Annotations click to browse term
  biological_process 14835
    metabolic process 10258
      organic substance metabolic process 9758
        macromolecule metabolic process 8460
          macromolecule catabolic process 1371
            protein catabolic process 914
              cellular protein catabolic process 758
                proteolysis involved in cellular protein catabolic process 703
                  modification-dependent protein catabolic process 615
                    ubiquitin-dependent protein catabolic process 609
                      proteasome-mediated ubiquitin-dependent protein catabolic process 421
                        ubiquitin-dependent ERAD pathway 78
                          ubiquitin-dependent glycoprotein ERAD pathway 4
                            mannose trimming involved in glycoprotein ERAD pathway 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.